Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0664 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0352 | 0.4865 | 0.4365 |
Echinococcus multilocularis | insulin receptor | 0.0209 | 0.252 | 0.1792 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0247 | 0.314 | 0.2472 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0655 | 0.9849 | 0.9849 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0655 | 0.9849 | 0.9849 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0247 | 0.314 | 0.2472 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0209 | 0.252 | 0.1792 |
Echinococcus multilocularis | 0.0203 | 0.2412 | 0.1673 | |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.011 | 0.0887 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0352 | 0.4865 | 0.4365 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0209 | 0.252 | 0.252 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0664 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0209 | 0.252 | 0.252 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0664 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.011 | 0.0887 | 0.0887 |
Schistosoma mansoni | tyrosine kinase | 0.0348 | 0.4804 | 0.4298 |
Schistosoma mansoni | tyrosine kinase | 0.0348 | 0.4804 | 0.4298 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0209 | 0.252 | 0.1792 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0655 | 0.9849 | 0.9834 |
Schistosoma mansoni | tyrosine kinase | 0.0209 | 0.252 | 0.1792 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0664 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0352 | 0.4865 | 0.4365 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0664 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0664 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0664 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0247 | 0.314 | 0.2472 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0664 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0209 | 0.252 | 0.1792 |
Schistosoma mansoni | tyrosine kinase | 0.0655 | 0.9849 | 0.9834 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.011 | 0.0887 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.011 | 0.0887 | 0.0887 |
Echinococcus granulosus | insulin receptor | 0.0209 | 0.252 | 0.1792 |
Leishmania major | 0.0664 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0352 | 0.4865 | 0.4365 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.011 | 0.0887 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0655 | 0.9849 | 0.9834 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0352 | 0.4865 | 0.4365 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.0887 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0348 | 0.4804 | 0.4298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 713 uM | Inhibition of fluorescent (GpYEEI) binding to Src protein tryrosine kinase SH2 domain | ChEMBL. | 15261270 |
IC50 (binding) | = 713 uM | Inhibition of fluorescent (GpYEEI) binding to Src protein tryrosine kinase SH2 domain | ChEMBL. | 15261270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.