Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0323 | 0.2774 | 0.2668 |
Schistosoma mansoni | tyrosine kinase | 0.0346 | 0.3299 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0644 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0644 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0323 | 0.2774 | 0.2668 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0323 | 0.2774 | 0.2668 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.3217 | 0.3117 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0323 | 0.2774 | 0.2774 |
Schistosoma mansoni | tyrosine kinase | 0.0346 | 0.3299 | 0.32 |
Leishmania major | 0.0323 | 0.2774 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0644 | 1 | 1 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0482 | 0.6351 | 0.6351 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0346 | 0.3299 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0644 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.3217 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0346 | 0.3299 | 0.32 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0323 | 0.2774 | 0.2668 |
Echinococcus multilocularis | insulin receptor | 0.0206 | 0.0145 | 0.0145 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0323 | 0.2774 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0346 | 0.3299 | 0.32 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0323 | 0.2774 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.3217 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0323 | 0.2774 | 0.5 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0482 | 0.6351 | 0.6297 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0323 | 0.2774 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0206 | 0.0145 | 0.0145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.06 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 0.06 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 11.88 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 11.88 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.