Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0338 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0319 | 0.2776 | 0.267 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0319 | 0.2776 | 0.2776 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.3299 | 0.32 |
Leishmania major | 0.0319 | 0.2776 | 0.5 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0319 | 0.2776 | 0.267 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.3299 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0636 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0636 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0319 | 0.2776 | 0.267 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0342 | 0.3299 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0203 | 0.0145 | 0.0145 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0319 | 0.2776 | 0.267 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0342 | 0.3299 | 0.32 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0319 | 0.2776 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0319 | 0.2776 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0338 | 0.3217 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0319 | 0.2776 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0319 | 0.2776 | 0.5 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0482 | 0.6482 | 0.643 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0203 | 0.0145 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0636 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0342 | 0.3299 | 0.3299 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0482 | 0.6482 | 0.6482 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0636 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0338 | 0.3217 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 0.24 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 12.23 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 12.23 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.