TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.266 | Formula: C17H14BrNO5S
H donors: 1 H acceptors: 3 LogP: 3.67 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cccc2c1oc(=O)c(c2)S(=O)(=O)Nc1ccc(cc1)Br
InChi: 1S/C17H14BrNO5S/c1-2-23-14-5-3-4-11-10-15(17(20)24-16(11)14)25(21,22)19-13-8-6-12(18)7-9-13/h3-10,19H,2H2,1H3
InChiKey: DMKYFPUXJWMJGK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0036	0.0244	0.0244
Schistosoma mansoni	tar DNA-binding protein	0.0282	0.4655	0.6939
Trichomonas vaginalis	replication factor C large subunit, putative	0.0022	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0279	0.0279
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0034	0.0218	0.5
Brugia malayi	AKH receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0579	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0279	0.0599
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0279	0.0416
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0279	0.0599
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0279	0.0279
Echinococcus multilocularis	serotonin receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	somatostatin receptor	0.0038	0.0279	0.0599
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0216	0.0322
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0279	0.0416
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0416
Schistosoma mansoni	tar DNA-binding protein	0.0282	0.4655	0.6939
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0599
Echinococcus multilocularis	GPCR, family 2	0.0183	0.289	0.6208
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0279	0.0599
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0279	0.0416
Brugia malayi	G protein-coupled receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0183	0.289	0.6208
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	N-terminal motif family protein	0.02	0.3186	0.3186
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0279	0.0279
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0279	0.0599
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0416
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0599
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0034	0.0218	0.1928
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	serotonin receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0579	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0022	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0279	0.0599
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0599
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	smad	0.0034	0.0216	0.0464
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0183	0.289	0.289
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0279	0.0599
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0216	0.0322
Schistosoma mansoni	smad	0.0034	0.0216	0.0322
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0279	0.0279
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0183	0.289	0.6208
Schistosoma mansoni	hypothetical protein	0.0183	0.289	0.4307
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Brugia malayi	larval opioid receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0244	0.0524
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0085	0.113	0.113
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0416
Brugia malayi	MH2 domain containing protein	0.0505	0.8664	0.8664
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0599
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0416
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0416
Entamoeba histolytica	hypothetical protein	0.0036	0.0244	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0244	0.0524
Schistosoma mansoni	tar DNA-binding protein	0.0282	0.4655	0.6939
Loa Loa (eye worm)	hypothetical protein	0.02	0.3186	0.3186
Onchocerca volvulus		0.0327	0.5468	1
Onchocerca volvulus		0.0038	0.0279	0.051
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	tar DNA binding protein	0.0282	0.4655	1
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0416
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0218	0.1928
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0279	0.0599
Brugia malayi	Latrophilin receptor protein 2	0.0183	0.289	0.289
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0416
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0416
Echinococcus granulosus	hypothetical protein	0.0038	0.0279	0.0599
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0	0.5
Schistosoma mansoni	hypothetical protein	0.0183	0.289	0.4307
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Brugia malayi	isocitrate dehydrogenase	0.0034	0.0218	0.0218
Onchocerca volvulus		0.0038	0.0279	0.051
Brugia malayi	GnHR receptor homolog	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0279	0.0599
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0279	0.0599
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Trypanosoma cruzi	PAB1-binding protein , putative	0.0085	0.113	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0244	0.0363
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0279	0.0599
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0183	0.289	0.289
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0216	0.0464
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0216	0.0216
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0279	0.0599
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0279	0.0416
Loa Loa (eye worm)	MH2 domain-containing protein	0.0505	0.8664	0.8664
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0085	0.113	0.113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	hypothetical protein	0.0396	0.6709	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	smad	0.0034	0.0216	0.0464
Brugia malayi	Serotonin receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0279	0.0599
Loa Loa (eye worm)	Smad1	0.0034	0.0216	0.0216
Plasmodium falciparum	ataxin-2 like protein, putative	0.0085	0.113	1
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0279	0.0599
Brugia malayi	MH2 domain containing protein	0.0034	0.0216	0.0216
Trypanosoma cruzi	PAB1-binding protein , putative	0.0085	0.113	1
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0416
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.02	0.3186	0.5826
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.0218	0.1928
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	MH1 domain containing protein	0.0034	0.0216	0.0216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	tar DNA-binding protein	0.0282	0.4655	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Treponema pallidum	DNA ligase (lig)	0.0022	0	0.5
Brugia malayi	G-protein coupled receptor	0.0038	0.0279	0.0279
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0022	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0279	0.0599
Leishmania major	hypothetical protein, conserved	0.0085	0.113	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0279	0.0599
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0216	0.0464
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0282	0.4655	0.4655
Loa Loa (eye worm)	hypothetical protein	0.0396	0.6709	0.6709
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0279	0.0599
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0183	0.289	0.289
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0216	0.0322
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0034	0.0218	0.1928
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0279	0.0599
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0279	0.0279
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0216	0.0216
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0279	0.0599
Plasmodium falciparum	ataxin-2 like protein, putative	0.0085	0.113	1
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0279	0.0279
Entamoeba histolytica	hypothetical protein	0.0036	0.0244	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	hypothetical protein	0.0183	0.289	0.4307
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0279	0.0599
Brugia malayi	Serotonin receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0244	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0416
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0279	0.0599
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Chlamydia trachomatis	DNA ligase	0.0022	0	0.5
Onchocerca volvulus		0.0038	0.0279	0.051
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0279	0.0599
Schistosoma mansoni	hypothetical protein	0.0038	0.0286	0.0426
Schistosoma mansoni	Smad4	0.0034	0.0216	0.0322
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0022	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0038	0.0279	0.0279
Entamoeba histolytica	hypothetical protein	0.0036	0.0244	1
Brugia malayi	Smad1	0.0034	0.0216	0.0216
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0034	0.0218	0.1928
Schistosoma mansoni	hypothetical protein	0.0038	0.0279	0.0416
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0279	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	neuropeptide F receptor	0.0038	0.0279	0.0279
Onchocerca volvulus		0.0038	0.0279	0.051
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0034	0.0218	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0416
Brugia malayi	G-protein coupled receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	MH1 domain containing protein	0.0034	0.0216	0.0216
Echinococcus granulosus	tar DNA binding protein	0.0282	0.4655	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0183	0.289	0.6208
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0279	0.0599
Brugia malayi	neuropeptide F receptor	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0279	0.0416
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0216	0.0464
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Brugia malayi	TAR-binding protein	0.0282	0.4655	0.4655
Loa Loa (eye worm)	transcription factor SMAD2	0.0505	0.8664	0.8664
Onchocerca volvulus		0.0038	0.0279	0.051
Echinococcus granulosus	GPCR family 2	0.0183	0.289	0.6208
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0327	0.5468	0.5468
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0183	0.289	0.6208
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0279	0.0416
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0034	0.0218	0.0325
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0279	0.0416
Echinococcus granulosus	serotonin receptor	0.0038	0.0279	0.0599
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0034	0.0218	0.0468
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0279	0.0416
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	Smad4	0.0034	0.0216	0.0464
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0416
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.0218	0.1928
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0279	0.0599
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0218	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0218	0.0468
Loa Loa (eye worm)	RNA binding protein	0.0282	0.4655	0.4655
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0279	0.0416
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0279	0.0279
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0279	0.0599
Brugia malayi	hypothetical protein	0.0055	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0038	0.0286	0.0613
Onchocerca volvulus		0.0038	0.0279	0.051
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0218	0.0468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0279	0.0279
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0279	0.051
Echinococcus multilocularis	isocitrate dehydrogenase	0.0034	0.0218	0.0468
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0279	0.0599
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0279	0.0599
Schistosoma mansoni	myosin xvIII	0.0038	0.0279	0.0416
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0279	0.0599
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0279	0.0599
Echinococcus granulosus	sex peptide receptor	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Entamoeba histolytica	hypothetical protein	0.0036	0.0244	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0599
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0279	0.0279
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0034	0.0218	0.1928
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0279	0.0599
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0216	0.0322
Brugia malayi	latrophilin 2 splice variant baaae	0.0396	0.6709	0.6709
Brugia malayi	hypothetical protein	0.0327	0.5468	0.5468
Toxoplasma gondii	LsmAD domain-containing protein	0.0085	0.113	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0279	0.0599
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0599
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0279	0.0279
Brugia malayi	sulfakinin receptor protein	0.0038	0.0279	0.0279
Plasmodium vivax	ataxin-2 like protein, putative	0.0085	0.113	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0279	0.0416
Brugia malayi	MH2 domain containing protein	0.0034	0.0216	0.0216
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0038	0.0286	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0279	0.0416
Schistosoma mansoni	adenoreceptor	0.0038	0.0279	0.0416
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0279	0.051
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0218	0.1928
Schistosoma mansoni	hypothetical protein	0.0183	0.289	0.4307
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0279	0.0416
Brugia malayi	RNA recognition motif domain containing protein	0.0282	0.4655	0.4655
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0279	0.0279
Loa Loa (eye worm)	TAR-binding protein	0.0282	0.4655	0.4655
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0279	0.0599
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0279	0.0599
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0279	0.0416
Schistosoma mansoni	amine GPCR	0.0038	0.0279	0.0416
Brugia malayi	Dopamine receptor	0.0038	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0279	0.0599
Onchocerca volvulus		0.0038	0.0279	0.051
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0279	0.0279
Echinococcus granulosus	Smad4	0.0034	0.0216	0.0464
Schistosoma mansoni	tar DNA-binding protein	0.0282	0.4655	0.6939
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0216	0.0464
Brugia malayi	RE15519p	0.0038	0.0279	0.0279
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0034	0.0218	0.0218
Brugia malayi	Isocitrate dehydrogenase	0.0034	0.0218	0.0218
Onchocerca volvulus		0.0038	0.0279	0.051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Brugia malayi	RNA binding protein	0.0282	0.4655	0.4655
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0022	0	0.5
Brugia malayi	hypothetical protein	0.0038	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0038	0.0279	0.0416
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0279	0.0599
Trypanosoma brucei	PAB1-binding protein , putative	0.0085	0.113	1
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0279	0.0416
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0279	0.0599
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0579	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0279	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0279	0.0279
Giardia lamblia	Replication factor C, subunit 1	0.0022	0	0.5
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0022	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 52 uM	Concentration required to inhibit growth of DU145 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 52 uM	Concentration required to inhibit growth of DU145 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 58 uM	Concentration required to inhibit growth of K562 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 58 uM	Concentration required to inhibit growth of K562 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 64 uM	Concentration required to inhibit growth of BT20 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 64 uM	Concentration required to inhibit growth of BT20 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 74 uM	Concentration required to inhibit growth of H157 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 74 uM	Concentration required to inhibit growth of H157 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 85 uM	Concentration required to inhibit growth of DLD-1 cells by 50% after 96h of treatment	ChEMBL.	15225733
GI50 (functional)	= 85 uM	Concentration required to inhibit growth of DLD-1 cells by 50% after 96h of treatment	ChEMBL.	15225733

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 322917