Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0333 | 0.4203 | 0.3178 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0333 | 0.4203 | 0.3178 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.4151 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.4151 | 0.3117 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0333 | 0.4203 | 1 |
Leishmania major | 0.0333 | 0.4203 | 0.5 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0334 | 0.4222 | 0.3299 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0621 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0333 | 0.4203 | 0.3178 |
Schistosoma mansoni | tyrosine kinase | 0.033 | 0.4151 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0334 | 0.4222 | 0.32 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0333 | 0.4203 | 0.3277 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0333 | 0.4203 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0198 | 0.1502 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0333 | 0.4203 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0198 | 0.1502 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0621 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0333 | 0.4203 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0621 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0333 | 0.4203 | 0.3178 |
Schistosoma mansoni | tyrosine kinase | 0.0334 | 0.4222 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0334 | 0.4222 | 0.32 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0334 | 0.4222 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0621 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 7.8 uM | Concentration required to inhibit in vitro DNA gyrase activity isolated from Escherichia coli | ChEMBL. | 15357962 |
Activity (binding) | = 7.8 uM | Concentration required to inhibit in vitro DNA gyrase activity isolated from Escherichia coli | ChEMBL. | 15357962 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli TLC | ChEMBL. | 15357962 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli TLC | ChEMBL. | 15357962 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli LKY | ChEMBL. | 15357962 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli LKY | ChEMBL. | 15357962 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli WT | ChEMBL. | 15357962 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration required against Gram-negative Escherichia coli WT | ChEMBL. | 15357962 |
MIC (functional) | = 32 ug ml-1 | Minimum inhibitory concentration required against Gram-positive Enterococcus faecalis | ChEMBL. | 15357962 |
MIC (functional) | = 32 ug ml-1 | Minimum inhibitory concentration required against Gram-positive Staphylococcus aureus | ChEMBL. | 15357962 |
MIC (functional) | = 32 ug ml-1 | Minimum inhibitory concentration required against Gram-positive Streptococcus pyogenes | ChEMBL. | 15357962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.