Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
E (functional) | = 69 % | Efficacy in calcium flux assay using HEK-293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5 relative to 10 uM dopamine | ChEMBL. | 15380206 |
E (functional) | = 69 % | Efficacy in calcium flux assay using HEK-293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5 relative to 10 uM dopamine | ChEMBL. | 15380206 |
EC50 (functional) | = 96 nM | Agonist activity was calculated in calcium flux assay using HEK-293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5 | ChEMBL. | 15380206 |
EC50 (functional) | = 96 nM | Agonist activity was calculated in calcium flux assay using HEK-293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5 | ChEMBL. | 15380206 |
Ki (binding) | 0 nM | In vitro ability to inhibit [3H]-6b binding to human Dopamine receptor D4.4; ND denotes not determined | ChEMBL. | 15380206 |
Ki (binding) | 0 nM | In vitro ability to inhibit [3H]-spiperone binding to human Dopamine receptor D4.4; ND denotes not determined | ChEMBL. | 15380206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.