Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 105 nM | inhibitory concentration of the crude compound against growth of chloroquine resistant strain of plasmodium falciparum parasite evaluated by rapid screening on FcB1 | ChEMBL. | 15357968 |
IC50 (functional) | = 105 nM | inhibitory concentration of the crude compound against growth of chloroquine resistant strain of plasmodium falciparum parasite evaluated by rapid screening on FcB1 | ChEMBL. | 15357968 |
Inhibition (functional) | = 0 % | In vitro ability of the compound to inhibit beta-hematin(synthetic equivalent of hemozoin) formation in Plasmodium falciparum (percentage of inhibition at 100 uM) | ChEMBL. | 15357968 |
Inhibition (functional) | = 0 % | In vitro ability of the compound to inhibit beta-hematin(synthetic equivalent of hemozoin) formation in Plasmodium falciparum (percentage of inhibition at 100 uM) | ChEMBL. | 15357968 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15357968 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.