Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | Get druggable targets OG5_133100 | All targets in OG5_133100 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0061 | 0.028 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.036 | 0.3861 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0061 | 0.028 | 0.5 |
Brugia malayi | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0061 | 0.028 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0061 | 0.028 | 0.0543 |
Onchocerca volvulus | Bile acid receptor homolog | 0.036 | 0.3861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0468 | 0.5165 | 1 |
Schistosoma mansoni | amine oxidase | 0.0061 | 0.028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.081 | 0.9264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Brugia malayi | SWIRM domain containing protein | 0.0061 | 0.028 | 0.0726 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0061 | 0.028 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0.028 | 0.5 |
Echinococcus multilocularis | 0.0061 | 0.028 | 0.0543 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0061 | 0.028 | 0.0726 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0.028 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0061 | 0.028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.3861 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0061 | 0.028 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0061 | 0.028 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0061 | 0.028 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0061 | 0.028 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0061 | 0.028 | 0.0543 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0061 | 0.028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.028 | 0.0726 |
Schistosoma mansoni | amine oxidase | 0.0061 | 0.028 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0061 | 0.028 | 0.5 |
Onchocerca volvulus | 0.0061 | 0.028 | 0.0726 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0061 | 0.028 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0061 | 0.028 | 0.0543 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0061 | 0.028 | 0.5 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0468 | 0.5165 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0061 | 0.028 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0061 | 0.028 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0871 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.47 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | = 0.47 uM | Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | > 101 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
IC50 (binding) | > 101 uM | Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells | ChEMBL. | 15324874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.