Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3734 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1474 | 0.3752 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3734 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1474 | 0.3752 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3734 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1474 | 0.3752 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1474 | 0.3752 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3734 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3734 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3734 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3734 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3734 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0117 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3734 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0117 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1474 | 0.3752 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1474 | 0.3752 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 125 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus | ChEMBL. | 7310807 |
MIC (functional) | > 250 ug ml-1 | In vitro minimum inhibitory concentration against Proteus mirabilis | ChEMBL. | 7310807 |
MID (functional) | < 0.5 | Minimum inhibitory dilution of medicated rat urine tested in vitro for antibacterial activity against Staphylococcus aureus; Less than 1:2 | ChEMBL. | 7310807 |
MID (functional) | < 0.5 | Minimum inhibitory dilution of medicated rat urine tested in vitro for antibacterial activity against Proteus mirabilis; Less than 1:2 | ChEMBL. | 7310807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.