Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0204 | 0.2933 | 0.284 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2213 | 0.2512 |
Echinococcus granulosus | geminin | 0.0176 | 0.2213 | 0.2399 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0474 | 1 | 1 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0097 | 0.013 | 0.0148 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0851 | 0.0966 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.2933 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2213 | 0.2512 |
Echinococcus granulosus | thymidylate synthase | 0.0428 | 0.8808 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0474 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0474 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0428 | 0.8808 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0428 | 0.8808 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0428 | 0.8808 | 1 |
Brugia malayi | hypothetical protein | 0.0204 | 0.2933 | 0.333 |
Brugia malayi | FolC bifunctional protein | 0.0097 | 0.013 | 0.0148 |
Echinococcus multilocularis | geminin | 0.0176 | 0.2213 | 0.2399 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0474 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0204 | 0.2933 | 0.323 |
Brugia malayi | thymidylate synthase | 0.0428 | 0.8808 | 1 |
Loa Loa (eye worm) | FolC protein | 0.0097 | 0.013 | 0.0148 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0851 | 0.0966 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0428 | 0.8808 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0428 | 0.8808 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0474 | 1 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0097 | 0.013 | 0.5 |
Onchocerca volvulus | 0.0428 | 0.8808 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0851 | 0.0966 |
Mycobacterium ulcerans | thymidylate synthase | 0.0428 | 0.8808 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of Escherichia coli thymidine phosphorylase at 106.3 to 212.6 uM | ChEMBL. | 17870212 | |
IC50 (binding) | uM | Inhibition of Thymidine phosphorylase from Escherichia coli; no inhibition at 213 uM | ChEMBL. | 15454205 |
IC50 (binding) | NI 0 uM | Inhibition of Thymidine phosphorylase from Escherichia coli; no inhibition at 213 uM | ChEMBL. | 15454205 |
Km (binding) | = 44.4 uM | Michaelis-Menten Constant for bovine Xanthine oxidase | ChEMBL. | 15454205 |
Km (binding) | = 44.4 uM | Michaelis-Menten Constant for bovine Xanthine oxidase | ChEMBL. | 15454205 |
Km (binding) | = 44.4 uM | Activity of bovine xanthine oxidase | ChEMBL. | 17870212 |
Vmax (binding) | = 0.982 microM/min | Activity of bovine xanthine oxidase | ChEMBL. | 17870212 |
Vmax (binding) | = 0.98 mM/min | Maximum binding velocity for bovine Xanthine oxidase | ChEMBL. | 15454205 |
Vmax (binding) | = 0.9800000000000002 mM/min | Maximum binding velocity for bovine Xanthine oxidase | ChEMBL. | 15454205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.