Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0812 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0812 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0812 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0812 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0812 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0812 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0812 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0812 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 208 nM | Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
EC50 (functional) | = 208 nM | Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
IA (functional) | = 75 % | Percent intrinsic activity of alpha-MSH-stimulated cAMP level in CHO cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
IA (functional) | = 75 % | Percent intrinsic activity of alpha-MSH-stimulated cAMP level in CHO cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
Ki (binding) | = 102 nM | Displacement of [125I]-NDP-MSH from HEK293 cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
Ki (binding) | = 102 nM | Displacement of [125I]-NDP-MSH from HEK293 cells expressing human melanocortin-4 receptor | ChEMBL. | 15357964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.