Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 2 | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | protein jagged 1 | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Schistosoma mansoni | peroxidasin | 0.0351 | 0.981 | 0.9893 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0351 | 0.981 | 0.9881 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Echinococcus multilocularis | peroxidasin | 0.0358 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Schistosoma mansoni | slit | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0351 | 0.981 | 0.9733 |
Echinococcus multilocularis | slit 2 protein | 0.0113 | 0.2892 | 0.2892 |
Echinococcus granulosus | neural cadherin | 0.0113 | 0.2892 | 0.2892 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0107 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0113 | 0.2892 | 0.5 |
Giardia lamblia | High cysteine protein | 0.0113 | 0.2892 | 0.5 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Onchocerca volvulus | Peroxidase homolog | 0.0351 | 0.981 | 0.9881 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Echinococcus granulosus | fibropellin Ia | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0351 | 0.981 | 0.9809 |
Onchocerca volvulus | Peroxidasin homolog | 0.0354 | 0.9893 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0354 | 0.9893 | 0.9893 |
Brugia malayi | Animal haem peroxidase family protein | 0.0354 | 0.9893 | 0.985 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0107 | 0.0084 |
Schistosoma mansoni | peroxidasin | 0.0355 | 0.9917 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0113 | 0.2892 | 0.2892 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Brugia malayi | Animal haem peroxidase family protein | 0.0351 | 0.981 | 0.9733 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Echinococcus granulosus | protein jagged 1 | 0.0113 | 0.2892 | 0.2892 |
Echinococcus multilocularis | neural cadherin | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0351 | 0.981 | 0.9809 |
Echinococcus granulosus | protein jagged 2 | 0.0113 | 0.2892 | 0.2892 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Echinococcus granulosus | slit 2 protein | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0113 | 0.2892 | 0.2892 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0107 | 0.0107 |
Onchocerca volvulus | Peroxidase homolog | 0.0351 | 0.981 | 0.9881 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0113 | 0.2892 | 0.2892 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0113 | 0.2892 | 0.2892 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.4902 | 0.2829 |
Onchocerca volvulus | 0.0351 | 0.981 | 0.9881 | |
Schistosoma mansoni | cell polarity protein | 0.0113 | 0.2892 | 0.2916 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Echinococcus multilocularis | fibropellin Ia | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0351 | 0.981 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0351 | 0.981 | 0.9733 |
Brugia malayi | Animal haem peroxidase family protein | 0.0351 | 0.981 | 0.9733 |
Echinococcus granulosus | notch | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.4552 | 0.2372 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | Notch2 | 0.0113 | 0.2892 | 0.2875 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.4902 | 0.4891 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0113 | 0.2892 | 0.2892 |
Echinococcus multilocularis | notch | 0.0113 | 0.2892 | 0.2892 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0023 | 0.0023 |
Onchocerca volvulus | Peroxidasin homolog | 0.0354 | 0.9893 | 1 |
Schistosoma mansoni | notch | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | protein jagged 1 | 0.0113 | 0.2892 | 0.2892 |
Echinococcus granulosus | delta-like protein 1 | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | protein jagged 2 | 0.0113 | 0.2892 | 0.2892 |
Echinococcus granulosus | peroxidasin | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0113 | 0.2892 | 0.2892 |
Onchocerca volvulus | Dual oxidase homolog | 0.0351 | 0.981 | 0.9881 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2892 | 0.2916 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Brugia malayi | hypothetical protein | 0.0351 | 0.981 | 0.9733 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0351 | 0.981 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus granulosus | protein jagged 1 | 0.0113 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | notch protein | 0.0113 | 0.2892 | 0.2875 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0113 | 0.2892 | 0.2892 |
Brugia malayi | Blistered cuticle protein 3 | 0.0351 | 0.981 | 0.9733 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Schistosoma mansoni | septate junction protein | 0.0113 | 0.2892 | 0.2916 |
Onchocerca volvulus | 0.0167 | 0.4439 | 0.221 | |
Onchocerca volvulus | 0.0351 | 0.981 | 0.9881 | |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0113 | 0.2892 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 1 | 1 |
Onchocerca volvulus | 0.0351 | 0.981 | 0.9881 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2892 | 0.2875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.