Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Geranylgeranyl transferase type I | Starlite/ChEMBL | References |
Bos taurus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0467 | 0.4089 | 0.383 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0982 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0467 | 0.4089 | 0.3898 |
Loa Loa (eye worm) | thymidylate synthase | 0.0982 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0982 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0982 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0138 | 0.0313 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0982 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0982 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0467 | 0.4089 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0982 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0982 | 1 | 1 |
Onchocerca volvulus | 0.0982 | 1 | 0.5 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.0467 | 0.4089 | 0.383 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.92 nM | Inhibition of bovine farnesyltransferase | ChEMBL. | 15454229 |
IC50 (binding) | = 0.92 nM | Inhibition of bovine farnesyltransferase | ChEMBL. | 15454229 |
IC50 (binding) | = 3400 nM | Inhibition of bovine Geranylgeranyltransferase | ChEMBL. | 15454229 |
IC50 (binding) | = 3400 nM | Inhibition of bovine Geranylgeranyltransferase | ChEMBL. | 15454229 |
Inhibition (functional) | = 53 % | Percent inhibition of H-Ras transformed NIH-3T3-cell proliferation at 100 nM | ChEMBL. | 15454229 |
Inhibition (functional) | = 53 % | Percent inhibition of H-Ras transformed NIH-3T3-cell proliferation at 100 nM | ChEMBL. | 15454229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.