Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0488 | 0.5185 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0247 | 0.1107 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0488 | 0.5185 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0773 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0247 | 0.1107 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0415 | 0.3953 | 0.32 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0488 | 0.5185 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0488 | 0.5185 | 0.4664 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0415 | 0.3953 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0415 | 0.3953 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0773 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0773 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0488 | 0.5185 | 0.4585 |
Schistosoma mansoni | tyrosine kinase | 0.0411 | 0.3879 | 0.3117 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0488 | 0.5185 | 1 |
Leishmania major | 0.0488 | 0.5185 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0415 | 0.3953 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0411 | 0.3879 | 0.3117 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0773 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0488 | 0.5185 | 0.4585 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0488 | 0.5185 | 0.4585 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0415 | 0.3953 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0411 | 0.3879 | 0.3117 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0488 | 0.5185 | 0.4585 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.3 nM | In vitro inhibitory activity against Factor Xa | ChEMBL. | 15225723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.