Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0786 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0488 | 0.5072 | 0.4431 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0488 | 0.5072 | 0.4511 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0488 | 0.5072 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0786 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.3983 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0422 | 0.3983 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0786 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0251 | 0.1152 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0422 | 0.3983 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0251 | 0.1152 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0488 | 0.5072 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0488 | 0.5072 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0488 | 0.5072 | 0.4431 |
Schistosoma mansoni | tyrosine kinase | 0.0418 | 0.391 | 0.3117 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0488 | 0.5072 | 0.4431 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0786 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0488 | 0.5072 | 0.4431 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0422 | 0.3983 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.3983 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0418 | 0.391 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0418 | 0.391 | 0.3117 |
Leishmania major | 0.0488 | 0.5072 | 0.5 | |
Toxoplasma gondii | fructose-bisphospatase II | 0.0488 | 0.5072 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 2 uM | Concentration required to inhibit binding of [125I]-MCH radioligand to human melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes | ChEMBL. | 15341942 |
IC50 (binding) | > 2 uM | Concentration required to inhibit binding of [125I]-MCH radioligand to human melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes | ChEMBL. | 15341942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.