Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0145 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0145 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0145 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0145 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0145 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0145 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0145 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0145 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 1 | 1 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0145 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0145 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0145 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0145 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0145 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibitory activity against 5-hydroxytryptamine receptor 1A using (+/-)-[3H]-8-hydroxydipropylaminotetralin | ChEMBL. | 15357973 |
IC50 (binding) | = 110 nM | Inhibitory activity against human- serotonin reuptake transmitter using [3H]-citalopram as a radioligand | ChEMBL. | 15357973 |
IC50 (binding) | = 110 nM | Inhibitory activity against human- serotonin reuptake transmitter using [3H]-citalopram as a radioligand | ChEMBL. | 15357973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.