Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fk506-binding protein 1-like protein | 0.0502 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.8121 | 0.8121 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0502 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0502 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0502 | 1 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0502 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0502 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0502 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0134 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0134 | 0 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0502 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0134 | 0 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0502 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0433 | 0.8121 | 0.8121 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0502 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0502 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Onchocerca volvulus | 0.0134 | 0 | 0.5 | |
Schistosoma mansoni | immunophilin | 0.0502 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0134 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0502 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0502 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0134 | 0 | 0.5 |
Onchocerca volvulus | 0.0134 | 0 | 0.5 | |
Loa Loa (eye worm) | FKBP5 protein | 0.0502 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0134 | 0 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0502 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0502 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0433 | 0.8121 | 0.8121 |
Onchocerca volvulus | 0.0134 | 0 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0502 | 1 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0502 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0433 | 0.8121 | 0.8121 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0502 | 1 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0502 | 1 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0502 | 1 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0502 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0502 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IG50 (functional) | ND 0 uM | Concentration causing 50% inhibition of cancer cell growth against human renal A498 cell line; nd = not done | ChEMBL. | 15324893 |
IG50 (functional) | = 30 uM | Concentration causing 50% inhibition of cancer cell growth against human CNS U251 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 30 uM | Concentration causing 50% inhibition of cancer cell growth against human CNS U251 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human breast MCF-7/ADR cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human colon SW620 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human ovarian SKOV3 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human prostate DU145 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human breast MCF-7/ADR cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human colon SW620 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human ovarian SKOV3 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 40 uM | Concentration causing 50% inhibition of cancer cell growth against human prostate DU145 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 50 uM | Concentration causing 50% inhibition of cancer cell growth against human lung H522 cell line | ChEMBL. | 15324893 |
IG50 (functional) | = 50 uM | Concentration causing 50% inhibition of cancer cell growth against human lung H522 cell line | ChEMBL. | 15324893 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.