Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.1458 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.1458 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | protein jagged 2 | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0471 | 0.2335 | 0.1873 |
Giardia lamblia | High cysteine protein | 0.0471 | 0.2335 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0471 | 0.2335 | 0.2335 |
Onchocerca volvulus | 0.1458 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.1458 | 1 | 1 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0471 | 0.2335 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0471 | 0.2335 | 0.1873 |
Brugia malayi | Animal haem peroxidase family protein | 0.1458 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0471 | 0.2335 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1458 | 1 | 1 |
Onchocerca volvulus | 0.1458 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus granulosus | neural cadherin | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.1458 | 1 | 1 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Echinococcus multilocularis | notch | 0.0471 | 0.2335 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0244 | 0.0569 | 0.0569 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | peroxidasin | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0471 | 0.2335 | 0.1873 |
Echinococcus multilocularis | peroxidasin | 0.1458 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0471 | 0.2335 | 0.1873 |
Echinococcus multilocularis | protein jagged 2 | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0471 | 0.2335 | 0.1873 |
Onchocerca volvulus | Peroxidase homolog | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Onchocerca volvulus | Peroxidase homolog | 0.1458 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0471 | 0.2335 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1458 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0471 | 0.2335 | 0.2335 |
Onchocerca volvulus | 0.1458 | 1 | 1 | |
Echinococcus granulosus | neurogenic locus notch protein | 0.0471 | 0.2335 | 0.1873 |
Echinococcus multilocularis | protein jagged 1 | 0.0471 | 0.2335 | 0.1873 |
Brugia malayi | Animal haem peroxidase family protein | 0.1458 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | protein jagged 1 | 0.0471 | 0.2335 | 0.1873 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1458 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.1458 | 1 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | protein jagged 2 | 0.0471 | 0.2335 | 0.1873 |
Onchocerca volvulus | Peroxidasin homolog | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0471 | 0.2335 | 0.2335 |
Echinococcus granulosus | protein jagged 1 | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1458 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0471 | 0.2335 | 0.1873 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1458 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0471 | 0.2335 | 0.1873 |
Echinococcus granulosus | notch | 0.0471 | 0.2335 | 0.1873 |
Schistosoma mansoni | notch | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | septate junction protein | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | slit | 0.0471 | 0.2335 | 0.2335 |
Brugia malayi | Animal haem peroxidase family protein | 0.1458 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1458 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 0.2335 | 0.2335 |
Schistosoma mansoni | peroxidasin | 0.1458 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.