Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0231 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0231 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0231 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0231 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0231 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0231 | 0.5 | 0.5 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0231 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.15 nM | Compound was tested for its cytotoxicity by inhibiting the growth of MCF-7 cell line after 72 h | ChEMBL. | 15225730 |
IC50 (functional) | = 0.15 nM | Compound was tested for its cytotoxicity by inhibiting the growth of MCF-7 cell line after 72 h | ChEMBL. | 15225730 |
IC50 (functional) | = 0.36 nM | Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h | ChEMBL. | 15225730 |
IC50 (functional) | = 0.36 nM | Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h | ChEMBL. | 15225730 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15225730 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.