Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.046 | 0.199 | 0.199 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1866 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1118 | 0.5741 | 0.8215 |
Echinococcus multilocularis | geminin | 0.02 | 0.0503 | 0.0503 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.046 | 0.199 | 0.199 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1866 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1866 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1118 | 0.5741 | 0.8215 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1866 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1866 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.046 | 0.199 | 0.199 |
Brugia malayi | thymidylate synthase | 0.0434 | 0.1842 | 0.1842 |
Loa Loa (eye worm) | thymidylate synthase | 0.0434 | 0.1842 | 0.1842 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1337 | 0.6988 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0434 | 0.1842 | 0.1373 |
Loa Loa (eye worm) | hypothetical protein | 0.1118 | 0.5741 | 0.5741 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1118 | 0.5741 | 0.4779 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.046 | 0.199 | 0.199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.046 | 0.199 | 0.8446 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1337 | 0.6988 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0434 | 0.1842 | 0.1842 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.046 | 0.199 | 0.199 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1337 | 0.6988 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1866 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0111 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0.1842 | 1 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1337 | 0.6988 | 1 |
Brugia malayi | CHE-14 protein | 0.046 | 0.199 | 0.199 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1118 | 0.5741 | 0.8215 |
Brugia malayi | hypothetical protein | 0.0207 | 0.0544 | 0.0544 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1337 | 0.6988 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.046 | 0.199 | 0.199 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1118 | 0.5741 | 0.5741 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0525 | 0.2357 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.1118 | 0.5741 | 0.5741 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.0503 | 0.0503 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0434 | 0.1842 | 0.1842 |
Echinococcus granulosus | dihydrofolate reductase | 0.1866 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.046 | 0.199 | 0.199 |
Echinococcus granulosus | geminin | 0.02 | 0.0503 | 0.0503 |
Echinococcus granulosus | thymidylate synthase | 0.0434 | 0.1842 | 0.1842 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1118 | 0.5741 | 0.5741 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0525 | 0.2357 | 1 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.0503 | 0.0503 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1118 | 0.5741 | 0.5741 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.199 | 0.199 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0525 | 0.2357 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1337 | 0.6988 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1866 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0525 | 0.2357 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.046 | 0.199 | 0.199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0207 | 0.0544 | 0.2308 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1118 | 0.5741 | 0.8215 |
Echinococcus multilocularis | protein patched | 0.046 | 0.199 | 0.199 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0207 | 0.0544 | 0.0779 |
Schistosoma mansoni | dihydrofolate reductase | 0.1866 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.046 | 0.199 | 0.199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | NA 0 uM | In vitro minimum inhibitory concentration for the inhibition of human rhinovirus-14 (HRV-14) replication by binding to viral capsid; NA= inactive at the 10 micromol. | ChEMBL. | 2158559 |
MIC (functional) | = 5.18 uM | In vitro anti-rhinovirus activity of the compound was measured as mean MIC for five serotypes, HRV-1A, -2, -22, -41, and -50 | ChEMBL. | 2913305 |
MIC (functional) | = 35 uM | In vitro anti-rhinovirus activity was measured as maximum testable levels - highest concentration of compound which causes no apparent effect on the cell monolayers | ChEMBL. | 2913305 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.