Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0364 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0364 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0364 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0364 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth Index (functional) | = 0.96 | Growth index for Mycobacterium avium sub species paratuberculosis was measured relative to mycobactin J | ChEMBL. | 15369397 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.