Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 451 aa | 393 aa | 25.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0362 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0362 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0362 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0362 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0138 | 0.3555 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0138 | 0.3555 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0138 | 0.3555 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0362 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0362 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0138 | 0.3555 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0362 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0362 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0138 | 0.3555 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0362 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0138 | 0.3555 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 800 nM | In vitro insecticidal activity as inhibition of [3H]-EBOB binding to Gamma-aminobutyric acid GABA-A receptor of housefly neuronal membranes | ChEMBL. | 15341958 |
IC50 (binding) | = 800 nM | In vitro insecticidal activity as inhibition of [3H]-EBOB binding to Gamma-aminobutyric acid GABA-A receptor of housefly neuronal membranes | ChEMBL. | 15341958 |
Selectivity (binding) | = 31 | Ratio of binding affinity for mouse brain Gamma-aminobutyric acid receptor and housefly Gamma-aminobutyric acid receptor | ChEMBL. | 15341958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.