TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 523.582 | Formula: C30H29N5O4
H donors: 2 H acceptors: 4 LogP: 3.4 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1NC(=O)c1ccc(cc1)OCc1ccccn1)NC(=O)c1ccnc(c1)N1CCOCC1
InChi: 1S/C30H29N5O4/c1-21-5-8-24(33-30(37)23-11-13-32-28(18-23)35-14-16-38-17-15-35)19-27(21)34-29(36)22-6-9-26(10-7-22)39-20-25-4-2-3-12-31-25/h2-13,18-19H,14-17,20H2,1H3,(H,33,37)(H,34,36)
InChiKey: KYUIBCCUKPQZSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0029	0.0038
Schistosoma mansoni	SET domain protein	0.0052	0.0193	0.0255
Brugia malayi	G-protein coupled receptor	0.003	0.0029	0.0018
Schistosoma mansoni	hypothetical protein	0.0029	0.0025	0.0033
Echinococcus granulosus	histone h3 methyltransferase	0.0129	0.0766	0.1013
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0029	0.0038
Plasmodium falciparum	adenosylhomocysteinase	0.0679	0.4832	0.9616
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	Carm1-pending protein	0.0146	0.0887	0.097
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0194	0.1244	0.1349
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.0031	0.0037	0.0049
Brugia malayi	larval opioid receptor	0.003	0.0029	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	serotonin receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	DNA methyltransferase 2, putative	0.0199	0.1279	0.1692
Plasmodium vivax	S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative	0.0384	0.2652	0.5255
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Echinococcus multilocularis	spermidine synthase	0.0705	0.5024	0.6647
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0029	0.0038
Schistosoma mansoni	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	opsin-like receptor	0.003	0.0029	0.0038
Echinococcus granulosus	hypothetical protein	0.003	0.0029	0.0038
Echinococcus multilocularis	SET and MYND domain containing protein 3	0.0071	0.0333	0.044
Echinococcus granulosus	disco interacting protein 2	0.0154	0.0948	0.1254
Echinococcus granulosus	spermidine synthase	0.0705	0.5024	0.6647
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0029	0.0023	0.003
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Brugia malayi	hypothetical protein	0.0038	0.0094	0.009
Echinococcus granulosus	serotonin receptor	0.003	0.0029	0.0038
Trypanosoma cruzi	transcription elongation factor s-II, putative	0.0038	0.0094	0.0095
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0094	0.0103
Schistosoma mansoni	myosin xvIII	0.003	0.0029	0.0038
Echinococcus granulosus	DNA methyltransferase 2, putative	0.0199	0.1279	0.1692
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0029	0.0038
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.006	0.025	0.0302
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0029	0.0038
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0029	0.0038
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0194	0.1244	0.1621
Echinococcus multilocularis	histone lysine N methyltransferase, H3 lysine 36	0.005	0.0181	0.0239
Toxoplasma gondii	phosphorylase family protein	0.0194	0.1244	0.254
Schistosoma mansoni	adenosylhomocysteinase	0.042	0.2918	0.386
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0029	0.0038
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0025	0.0033
Leishmania major	spermidine synthase	0.0705	0.5024	0.6637
Schistosoma mansoni	cpg binding protein	0.0164	0.1026	0.1357
Loa Loa (eye worm)	hypothetical protein	0.09	0.647	0.7076
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.1048	0.7559	1
Echinococcus granulosus	fmrfamide receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.09	0.647	0.7076
Schistosoma mansoni	suppressor of variegation 4-20-related	0.0135	0.0809	0.107
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0029	0.0038
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0029	0.0038
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0029	0.0038
Leishmania major	arginine N-methyltransferase-like protein	0.0031	0.0037	0.0018
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0071	0.0093
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.0934	0.1236
Echinococcus granulosus	histone lysine n methyltransferase suv420h1	0.0135	0.0809	0.107
Brugia malayi	sulfakinin receptor protein	0.003	0.0029	0.0018
Schistosoma mansoni	biogenic amine receptor	0.003	0.0029	0.0038
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0029	0.0038
Leishmania major	methylthioadenosine phosphorylase, putative	0.1048	0.7559	1
Schistosoma mansoni	hypothetical protein	0.0029	0.0023	0.003
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0029	0.0032
Schistosoma mansoni	adenosylhomocysteinase	0.042	0.2918	0.386
Onchocerca volvulus		0.003	0.0029	0.0004
Leishmania major	S-adenosylhomocysteine hydrolase	0.0679	0.4832	0.6382
Onchocerca volvulus		0.0163	0.1014	0.0991
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0194	0.1244	0.1621
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	amine GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1543	0.1687
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.0037	0.0014
Schistosoma mansoni	uridine phosphorylase	0.0194	0.1244	0.1646
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0083	0.011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0029	0.0038
Schistosoma mansoni	enhancer of zeste ezh	0.0199	0.1281	0.1695
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0028
Plasmodium vivax	SET domain protein, putative	0.0127	0.0752	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0608	0.0665
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.09	0.647	0.7076
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1543	0.1687
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	adenosylhomocysteinase	0.042	0.2918	0.386
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0679	0.4832	0.482
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0029	0.0023	0.0025
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1262	0.9144	1
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Brugia malayi	SET domain containing protein	0.0135	0.0809	0.0873
Entamoeba histolytica	DNA (cytosine-5)-methyltransferase, putative	0.0199	0.1279	0.2613
Echinococcus granulosus	allatostatin A receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0029	0.0038
Brugia malayi	ORL1-like opioid receptor	0.003	0.0029	0.0018
Echinococcus granulosus	neuropeptide receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0029	0.0038
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0029	0.0038
Schistosoma mansoni	opsin-like receptor	0.003	0.0029	0.0038
Plasmodium falciparum	S-adenosylmethionine decarboxylase/ornithine decarboxylase	0.0384	0.2652	0.5255
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0029	0.0038
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.0037	0.0049
Trypanosoma brucei	uridine phosphorylase	0.0194	0.1244	0.1621
Echinococcus multilocularis	S adenosylmethionine decarboxylase proenzyme	0.0789	0.5646	0.747
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0146	0.0887	0.1173
Echinococcus granulosus	SET and MYND domain containing protein 3	0.0071	0.0333	0.044
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0029	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	amine GPCR	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Echinococcus granulosus	orexin receptor type 2	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0025	0.0028
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0194	0.1244	1
Echinococcus multilocularis	serotonin receptor	0.003	0.0029	0.0038
Toxoplasma gondii	hypothetical protein	0.0338	0.231	0.4756
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0029	0.0038
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Schistosoma mansoni	opsin-like receptor	0.003	0.0029	0.0038
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0029	0.0038
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0194	0.1244	0.1646
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0163	0.1014	0.1108
Plasmodium vivax	spermidine synthase, putative	0.0705	0.5024	1
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Toxoplasma gondii	hypothetical protein	0.0038	0.0094	0.0148
Plasmodium vivax	histone-lysine N-methyltransferase, putative	0.0082	0.0419	0.0788
Echinococcus multilocularis	disco interacting protein 2	0.0154	0.0948	0.1254
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0038	0.0094	0.0124
Onchocerca volvulus		0.003	0.0029	0.0004
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0789	0.5646	0.7462
Brugia malayi	GnHR receptor homolog	0.003	0.0029	0.0018
Brugia malayi	AKH receptor	0.003	0.0029	0.0018
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Trichomonas vaginalis	set domain proteins, putative	0.1378	1	1
Loa Loa (eye worm)	SET domain-containing protein	0.0135	0.0809	0.0885
Schistosoma mansoni	hypothetical protein	0.0052	0.0195	0.0258
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0029	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0029	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0025	0.0005
Onchocerca volvulus		0.003	0.0029	0.0004
Echinococcus granulosus	histone lysine N methyltransferase H3 lysine 36	0.005	0.0181	0.0239
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.0934	0.1236
Onchocerca volvulus		0.003	0.0029	0.0004
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.0037	0.0014
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0194	0.1244	0.254
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.011	0.0145
Echinococcus multilocularis	protein arginine methyltransferase	0.0031	0.0037	0.0049
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.006	0.025	0.0302
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0029	0.0004
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0194	0.1244	0.254
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Schistosoma mansoni	amine GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	biogenic amine receptor	0.003	0.0029	0.0038
Trypanosoma cruzi	spermidine synthase, putative	0.0705	0.5024	0.6637
Plasmodium vivax	protein arginine N-methyltransferase 1, putative	0.0031	0.0037	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1193	0.1305
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Toxoplasma gondii	DNA methyltransferase 2, putative	0.0199	0.1279	0.2613
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0029	0.0038
Brugia malayi	MTAP	0.1048	0.7559	0.8264
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.0934	0.1236
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.0934	0.1236
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0338	0.231	0.4571
Schistosoma mansoni	methylthioadenosine phosphorylase	0.1048	0.7559	1
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0679	0.4832	1
Loa Loa (eye worm)	S-adenosylmethionine decarboxylase proenzyme	0.0789	0.5646	0.6175
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0187	0.1193	0.1578
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0029	0.0038
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0029	0.0018
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0235	0.155	0.2051
Echinococcus granulosus	histone lysine methyltransferase setb	0.0187	0.1193	0.1578
Schistosoma mansoni	methylthioadenosine phosphorylase	0.1048	0.7559	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0029	0.0018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0199	0.1281	0.1695
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	cpg binding protein	0.0164	0.1026	0.1357
Brugia malayi	G protein-coupled receptor	0.003	0.0029	0.0018
Schistosoma mansoni	cpg binding protein	0.0163	0.1014	0.1341
Brugia malayi	Pre-SET motif family protein	0.1262	0.9144	1
Echinococcus multilocularis	somatostatin receptor	0.003	0.0029	0.0038
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0029	0.0038
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0029	0.0038
Brugia malayi	SET domain containing protein	0.0031	0.0039	0.003
Schistosoma mansoni	disco-interacting protein 2 (dip2)	0.0154	0.0948	0.1254
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0213	0.1386	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1543	0.1687
Entamoeba histolytica	hypothetical protein	0.0038	0.0094	0.0148
Echinococcus granulosus	adenosylhomocysteinase	0.0679	0.4832	0.6393
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0029	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.0516	0.0683
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	hepatoma derived growth factor protein	0.0038	0.0094	0.0124
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0027	0.0012	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0029	0.0032
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Schistosoma mansoni	biogenic amine receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0029	0.0038
Schistosoma mansoni	hypothetical protein	0.003	0.0029	0.0038
Schistosoma mansoni	neuropeptide receptor	0.003	0.0029	0.0038
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0127	0.0752	0.1516
Onchocerca volvulus		0.003	0.0029	0.0004
Toxoplasma gondii	C-5 cytosine-specific DNA methylase superfamily protein	0.0199	0.1279	0.2613
Loa Loa (eye worm)	hypothetical protein	0.006	0.025	0.0274
Brugia malayi	SET domain containing protein	0.0199	0.1281	0.139
Schistosoma mansoni	hypothetical protein	0.0038	0.0094	0.0124
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0094	0.0095
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0199	0.1281	0.1695
Mycobacterium tuberculosis	Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY)	0.0564	0.3984	0.5614
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	microtubule associated protein 2	0.0695	0.4953	0.6552
Chlamydia trachomatis	AMP nucleosidase	0.0194	0.1244	0.5
Trypanosoma brucei	cytosine-specific DNA methylase, putative	0.0199	0.1279	0.1667
Brugia malayi	Carm1-pending protein	0.0146	0.0887	0.0958
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0029	0.0038
Echinococcus granulosus	protein arginine methyltransferase	0.0031	0.0037	0.0049
Plasmodium falciparum	DNA (cytosine-5)-methyltransferase	0.0199	0.1279	0.2509
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0029	0.0038
Brugia malayi	jmjC domain containing protein	0.0096	0.0516	0.0552
Echinococcus granulosus	somatostatin receptor	0.003	0.0029	0.0038
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0083	0.011
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0679	0.4832	0.6382
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0029	0.0038
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0029	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0029	0.0038
Brugia malayi	hypothetical protein	0.0234	0.1543	0.1676
Echinococcus multilocularis	histone h3 methyltransferase	0.0129	0.0766	0.1013
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0038	0.0094	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	hypothetical protein	0.003	0.0029	0.0038
Loa Loa (eye worm)	SET domain-containing protein	0.0199	0.1281	0.1401
Brugia malayi	Dopamine receptor protein 1	0.003	0.0029	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Brugia malayi	NNMT/PNMT/TEMT family protein	0.09	0.647	0.7072
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0029	0.0018
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Echinococcus multilocularis	uridine phosphorylase 1	0.0194	0.1244	0.1646
Schistosoma mansoni	histone J3 methyltransferase	0.0129	0.0766	0.1013
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Brugia malayi	Adenosylhomocysteinase	0.0679	0.4832	0.5278
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0031	0.0037	0.0023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0187	0.1193	0.1578
Leishmania major	hypothetical protein, conserved	0.0038	0.0094	0.0095
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.1048	0.7559	1
Schistosoma mansoni	hypothetical protein	0.003	0.0029	0.0038
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0766	0.0837
Echinococcus granulosus	sex peptide receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.0934	0.1236
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0029	0.0038
Onchocerca volvulus		0.0235	0.155	0.1529
Leishmania major	modification methylase-like protein	0.0199	0.1279	0.1667
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0029	0.0038
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0194	0.1244	0.1621
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0025	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0631	0.069
Brugia malayi	Bromodomain containing protein	0.0029	0.0025	0.0014
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0679	0.4832	1
Echinococcus granulosus	hepatoma derived growth factor protein	0.0038	0.0094	0.0124
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0029	0.0018
Brugia malayi	Histone-lysine N-methyltransferase, H3 lysine-79 specific	0.0129	0.0766	0.0825
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0029	0.0038
Trypanosoma brucei	S-adenosylmethionine decarboxylase	0.0789	0.5646	0.7462
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0029	0.0038
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0194	0.1244	0.1224
Entamoeba histolytica	hypothetical protein	0.0194	0.1244	0.254
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0027	0.0012	0.0016
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0029	0.0038
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0029	0.0038
Entamoeba histolytica	hypothetical protein	0.006	0.025	0.0473
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.006	0.025	0.0473
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.0031	0.0037	0.0029
Echinococcus granulosus	uridine phosphorylase 1	0.0194	0.1244	0.1646
Echinococcus granulosus	peregrin	0.0068	0.031	0.041
Echinococcus multilocularis	peregrin	0.0068	0.031	0.041
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0679	0.4832	0.9616
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0029	0.0038
Plasmodium falciparum	purine nucleoside phosphorylase	0.0194	0.1244	0.2438
Schistosoma mansoni	hypothetical protein	0.0038	0.0094	0.0124
Schistosoma mansoni	hypothetical protein	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.254
Brugia malayi	P38 map kinase family protein 2	0.0152	0.0934	0.101
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.0934	0.1209
Trypanosoma cruzi	spermidine synthase, putative	0.0705	0.5024	0.6637
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	cpg binding protein	0.0164	0.1026	0.1357
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Trypanosoma cruzi	MIZ/SP-RING zinc finger, putative	0.0038	0.0094	0.0095
Giardia lamblia	UPL-1	0.0194	0.1244	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0679	0.4832	0.6382
Brugia malayi	SET domain containing protein	0.012	0.0694	0.0747
Brugia malayi	neuropeptide F receptor	0.003	0.0029	0.0018
Schistosoma mansoni	histamine h1 receptor	0.003	0.0029	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0146	0.0887	0.1173
Echinococcus granulosus	S adenosylmethionine decarboxylase proenzyme	0.0789	0.5646	0.747
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0194	0.1244	0.1222
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0029	0.0038
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0029	0.0032
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0679	0.4832	0.6382
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.0037	0.0049
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0029	0.0023	0.003
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0083	0.011
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0025	0.0033
Brugia malayi	jmjC domain containing protein	0.0037	0.0083	0.0077
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0029	0.0038
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0679	0.4832	0.482
Echinococcus granulosus	PWWP domain containing protein 2A	0.0038	0.0094	0.0124
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0029	0.0038
Schistosoma mansoni	uridine phosphorylase	0.0194	0.1244	0.1646
Schistosoma mansoni	protein arginine n-methyltransferase	0.0146	0.0887	0.1173
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0187	0.1193	0.1578
Schistosoma mansoni	microtubule-associated protein tau	0.0695	0.4953	0.6552
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.1048	0.7559	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Onchocerca volvulus		0.0117	0.0674	0.065
Onchocerca volvulus		0.003	0.0029	0.0004
Schistosoma mansoni	amine GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0029	0.0032
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.0934	0.1209
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.1048	0.7559	0.8267
Echinococcus granulosus	g protein coupled receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0029	0.0038
Plasmodium vivax	DNA (cytosine-5)-methyltransferase, putative	0.0199	0.1279	0.2509
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0029	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.1244	0.1224
Treponema pallidum	pfs protein (pfs)	0.0194	0.1244	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0029	0.0018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Trypanosoma brucei	transcription elongation factor s-II, putative	0.0038	0.0094	0.0095
Onchocerca volvulus		0.0038	0.0094	0.0069
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0679	0.4832	1
Onchocerca volvulus		0.0234	0.1543	0.1521
Loa Loa (eye worm)	uridine phosphorylase	0.0194	0.1244	0.1361
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	microtubule associated protein 2	0.0695	0.4953	0.6552
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0371	0.0491
Loa Loa (eye worm)	hypothetical protein	0.005	0.0179	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0319	0.0349
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Brugia malayi	Melatonin receptor type 1A	0.003	0.0029	0.0018
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0029	0.0038
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0679	0.4832	0.5682
Schistosoma mansoni	neuropeptide receptor	0.003	0.0029	0.0038
Schistosoma mansoni	amine GPCR	0.003	0.0029	0.0038
Brugia malayi	PWWP domain containing protein	0.0038	0.0094	0.009
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	methyltransferase protein 5	0.0029	0.0023	0.003
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.254
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0029	0.0038
Brugia malayi	hypothetical protein	0.006	0.025	0.0261
Onchocerca volvulus		0.003	0.0029	0.0004
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	histone lysine n methyltransferase suv420h1	0.0135	0.0809	0.107
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0194	0.1244	1
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.0934	0.1209
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.0516	0.0683
Loa Loa (eye worm)	adenosylhomocysteinase	0.0679	0.4832	0.5285
Brugia malayi	Protein arginine N-methyltransferase	0.0029	0.0023	0.0012
Brugia malayi	neuropeptide F receptor	0.003	0.0029	0.0018
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0029	0.0038
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Trypanosoma cruzi	spermidine synthase, putative	0.0705	0.5024	0.6637
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0029	0.0038
Echinococcus granulosus	protein arginine N methyltransferase 8	0.0031	0.0037	0.0049
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0025	0.0005
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0031	0.0037	0.0049
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0029	0.0018
Brugia malayi	Dopamine receptor protein 2	0.003	0.0029	0.0018
Brugia malayi	uridine phosphorylase family protein	0.0194	0.1244	0.1349
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.254
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0029	0.0038
Echinococcus granulosus	methylthioadenosine phosphorylase	0.1048	0.7559	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Toxoplasma gondii	phosphorylase family protein	0.0194	0.1244	0.254
Onchocerca volvulus		0.0038	0.0094	0.0069
Schistosoma mansoni	phd finger protein	0.0038	0.0094	0.0124
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0127	0.0752	0.0994
Onchocerca volvulus		0.003	0.0029	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0029	0.0032
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0297	0.057
Echinococcus granulosus	g protein coupled receptor	0.003	0.0029	0.0038
Trypanosoma brucei	S-adenosylmethionine decarboxylase proenzyme, putative	0.0789	0.5646	0.7462
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0029	0.0032
Mycobacterium ulcerans	spermidine synthase	0.0564	0.3984	0.4339
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0031	0.0037	0.0014
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	PWWP domain-containing protein	0.0038	0.0094	0.0103
Brugia malayi	RE15519p	0.003	0.0029	0.0018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	cpg binding protein	0.0164	0.1026	0.1357
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0029	0.0032
Echinococcus granulosus	neuropeptide receptor	0.003	0.0029	0.0038
Onchocerca volvulus		0.003	0.0029	0.0004
Brugia malayi	putative neuropeptide receptor	0.003	0.0029	0.0018
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.0934	0.1236
Echinococcus granulosus	PWWP domain containing protein 2A	0.0038	0.0094	0.0124
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Mycobacterium tuberculosis	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)	0.0854	0.6124	1
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0194	0.1244	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0029	0.0018
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.254
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0029	0.0018
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0127	0.0752	0.0994
Echinococcus multilocularis	histone lysine n methyltransferase setb1	0.0034	0.006	0.008
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0029	0.0038
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0029	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0029	0.0038
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0029	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0029	0.0038
Brugia malayi	Serotonin receptor	0.003	0.0029	0.0018
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.0934	0.1022
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0789	0.5646	0.7462
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0094	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.1244	0.1224
Schistosoma mansoni	DNA (cytosine-5)-methyltransferase	0.0199	0.1279	0.1692
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Onchocerca volvulus		0.003	0.0029	0.0004
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Schistosoma mansoni	neuropeptide receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0034	0.006	0.0066
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0029	0.0004
Onchocerca volvulus		0.003	0.0029	0.0004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0029	0.0038
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.254
Plasmodium falciparum	histone-lysine N-methyltransferase, putative	0.0082	0.0419	0.0788
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0146	0.0887	0.1797
Schistosoma mansoni	neuropeptide receptor	0.003	0.0029	0.0038
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0345	0.0457
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0029	0.0038
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.015	0.0916	0.1212
Leishmania major	S-adenosylmethionine decarboxylase	0.0789	0.5646	0.7462
Brugia malayi	G-protein coupled receptor	0.003	0.0029	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	adenosylhomocysteinase	0.042	0.2918	0.386
Onchocerca volvulus		0.0154	0.0948	0.0925
Treponema pallidum	uridine phosphorylase (udp)	0.0194	0.1244	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.0934	0.1209
Schistosoma mansoni	hypothetical protein	0.017	0.1064	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0948	0.1036
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0083	0.0091
Brugia malayi	S-adenosylmethionine decarboxylase proenzyme	0.0789	0.5646	0.617
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Leishmania major	nucleoside phosphorylase-like protein	0.0194	0.1244	0.1621
Brugia malayi	F/Y-rich N-terminus family protein	0.0029	0.0027	0.0016
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Schistosoma mansoni	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Plasmodium falciparum	spermidine synthase	0.0705	0.5024	1
Brugia malayi	Spermidine synthase	0.0705	0.5024	0.5489
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0255	0.0279
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Brugia malayi	hypothetical protein	0.0234	0.1543	0.1676
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	hepatoma derived growth factor	0.0038	0.0094	0.0124
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0029	0.0032
Loa Loa (eye worm)	spermidine synthase	0.0705	0.5024	0.5495
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	histone lysine n methyltransferase setb1	0.0034	0.006	0.008
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0679	0.4832	1
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.1048	0.7559	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0029	0.0038
Echinococcus granulosus	g protein coupled receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0029	0.0038
Echinococcus granulosus	purine nucleoside phosphorylase	0.0194	0.1244	0.1646
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0029	0.0038
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0029	0.0038
Schistosoma mansoni	hypothetical protein	0.0038	0.0094	0.0124
Schistosoma mansoni	adenoreceptor	0.003	0.0029	0.0038
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Schistosoma mansoni	hepatoma derived growth factor	0.0038	0.0094	0.0124
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0194	0.1244	1
Trypanosoma cruzi	spermidine synthase, putative	0.0705	0.5024	0.6637
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Trypanosoma brucei	spermidine synthase	0.0705	0.5024	0.6637
Onchocerca volvulus		0.003	0.0029	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Echinococcus granulosus	geminin	0.017	0.1064	0.1408
Brugia malayi	hypothetical protein	0.0038	0.0094	0.009
Brugia malayi	CXXC zinc finger family protein	0.0163	0.1014	0.1097
Brugia malayi	hypothetical protein	0.003	0.0029	0.0018
Brugia malayi	Serotonin receptor	0.003	0.0029	0.0018
Brugia malayi	Pre-SET motif family protein	0.0161	0.1002	0.1084
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0029	0.0038
Brugia malayi	PHD-finger family protein	0.0029	0.0025	0.0014
Echinococcus multilocularis	geminin	0.017	0.1064	0.1408
Echinococcus multilocularis	sex peptide receptor	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0029	0.0038
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0194	0.1244	0.1224
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0029	0.0038
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.006	0.025	0.0302
Brugia malayi	Disco-interacting protein 2 homolog	0.0154	0.0948	0.1024
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0029	0.0038
Echinococcus multilocularis	adenosylhomocysteinase	0.0679	0.4832	0.6393
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0029	0.0038
Brugia malayi	Dopamine receptor	0.003	0.0029	0.0018
Trypanosoma cruzi	S-adenosylmethionine decarboxylase proenzyme, putative	0.0789	0.5646	0.7462
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0679	0.4832	0.7353
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0029	0.0038
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.1048	0.7559	1
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.011	0.0145
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0029	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0029	0.0038
Schistosoma mansoni	adenosylhomocysteinase	0.0679	0.4832	0.6393
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0029	0.0032
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0028	0.0015	0.002
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0029	0.0038
Schistosoma mansoni	hypothetical protein	0.017	0.1064	0.1408
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0029	0.0032
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0029	0.0038
Trypanosoma cruzi	transcription elongation factor-like protein, putative	0.0038	0.0094	0.0095

Activities

Activity type	Activity value	Assay description	Source	Reference
Binding (ADMET)	= 99.89 %	Protein binding was determined in human	ChEMBL.	15454231
Bioavailabiility (ADMET)	= 46 %	Oral bioavailability of the compound was determined at 3 mg/kg	ChEMBL.	15454231
Clearance (ADMET)	= 10 ml min-1 kg-1	Clearence of the compound after iv administration of 1 mg/kg	ChEMBL.	15454231
Distribution (ADMET)	= 1.6 l kg-1	Volume distribution of the compound after iv administration of 1 mg/kg	ChEMBL.	15454231
IC50 (binding)	= 0.01 uM	Concentration required to inhibit human mitogen activated protein kinase p38 activity	ChEMBL.	15454231
IC50 (binding)	= 0.01 uM	Concentration required to inhibit human mitogen activated protein kinase p38 activity	ChEMBL.	15454231
IC50 (functional)	= 2.8 uM	Concentration required to inhibit lipopolysaccharide induced TNF-alpha release was determined in human whole blood	ChEMBL.	15454231
IC50 (functional)	= 2.8 uM	Concentration required to inhibit lipopolysaccharide induced TNF-alpha release was determined in human whole blood	ChEMBL.	15454231
Solubility	< 1 uM	Solubility of the compound was determined	ChEMBL.	15454231
T1/2 (ADMET)	= 2.9 hr	half life of the compound was determined after iv administration of 1 mg/kg	ChEMBL.	15454231

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	15454231

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL184012

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 324417