Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.7199 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0486 | 0.7199 | 1 |
Onchocerca volvulus | 0.0093 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0486 | 0.7199 | 0.7199 |
Echinococcus granulosus | carboxylesterase 5A | 0.0486 | 0.7199 | 0.7199 |
Brugia malayi | Carboxylesterase family protein | 0.0486 | 0.7199 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0486 | 0.7199 | 0.7199 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.7199 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0486 | 0.7199 | 0.7199 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0638 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0486 | 0.7199 | 0.7199 |
Loa Loa (eye worm) | carboxylesterase | 0.0486 | 0.7199 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0486 | 0.7199 | 0.7199 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0486 | 0.7199 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0486 | 0.7199 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | nM | Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor mu 1; ND denotes not determined | ChEMBL. | 15380196 |
EC50 (functional) | nM | Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1; ND denotes not determined | ChEMBL. | 15380196 |
EC50 (functional) | 0 nM | Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1; ND denotes not determined | ChEMBL. | 15380196 |
EC50 (binding) | 0 nM | Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor mu 1; ND denotes not determined | ChEMBL. | 15380196 |
Emax (functional) | % | Agonist activity as maximal effect in [35S]-GTP-gamma binding assay compared to 60 nM N/OFQ; ND denotes not determined | ChEMBL. | 15380196 |
Emax (binding) | % | Agonist activity as maximal effect in [35S]-GTP-gamma binding assay compared to 10 uM DAMGO; ND denotes not determined | ChEMBL. | 15380196 |
Emax (functional) | 0 % | Agonist activity as maximal effect in [35S]-GTP-gamma binding assay compared to 60 nM N/OFQ; ND denotes not determined | ChEMBL. | 15380196 |
Emax (binding) | 0 % | Agonist activity as maximal effect in [35S]-GTP-gamma binding assay compared to 10 uM DAMGO; ND denotes not determined | ChEMBL. | 15380196 |
Ki (binding) | nM | Inhibition of [3H]-diprenorphine binding to human Opioid receptor mu 1; ND denotes not determined | ChEMBL. | 15380196 |
Ki (binding) | 0 nM | Inhibition of [3H]-diprenorphine binding to human Opioid receptor mu 1; ND denotes not determined | ChEMBL. | 15380196 |
Ki (binding) | = 5670 nM | Inhibition of [3H]-Nociceptin binding to human Opioid receptor like 1 | ChEMBL. | 15380196 |
Ki (binding) | = 5670 nM | Inhibition of [3H]-Nociceptin binding to human Opioid receptor like 1 | ChEMBL. | 15380196 |
Ki (binding) | > 2 uM | Inhibition of [3H]-U69,593 binding to human Opioid receptor kappa 1 | ChEMBL. | 15380196 |
Ki (binding) | > 2 uM | Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 | ChEMBL. | 15380196 |
Ki (binding) | > 2 uM | Inhibition of [3H]-U69,593 binding to human Opioid receptor kappa 1 | ChEMBL. | 15380196 |
Ki (binding) | > 2 uM | Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 | ChEMBL. | 15380196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.