Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Macaca mulatta | Transporter | Starlite/ChEMBL | References |
Macaca mulatta | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0062 | 0.1127 | 0.1127 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | serotonin transporter | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0365 | 1 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0062 | 0.1127 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0062 | 0.1127 | 0.1127 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0062 | 0.1127 | 0.5 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0062 | 0.1127 | 0.1127 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.1127 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 0.3381 | 0.3381 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0365 | 1 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0062 | 0.1127 | 0.1127 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Plasmodium vivax | hypothetical protein, conserved | 0.0062 | 0.1127 | 0.5 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0062 | 0.1127 | 0.1127 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3381 | 0.3381 |
Onchocerca volvulus | 0.0062 | 0.1127 | 0.1127 | |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Onchocerca volvulus | 0.0062 | 0.1127 | 0.1127 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0139 | 0.3381 | 0.3381 |
Plasmodium vivax | amine transporter, putative | 0.0062 | 0.1127 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.1127 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0365 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 0.3381 | 0.3381 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | serotonin transporter b | 0.0365 | 1 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0139 | 0.3381 | 0.3381 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 0.3381 | 0.3381 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.1127 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.3381 | 0.3381 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0365 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0062 | 0.1127 | 0.1127 |
Brugia malayi | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Onchocerca volvulus | 0.0062 | 0.1127 | 0.1127 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | carboxylesterase | 0.0139 | 0.3381 | 0.3381 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0062 | 0.1127 | 0.1127 |
Brugia malayi | Carboxylesterase family protein | 0.0139 | 0.3381 | 0.3381 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0062 | 0.1127 | 0.1127 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0062 | 0.1127 | 0.1127 |
Plasmodium falciparum | transporter, putative | 0.0062 | 0.1127 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.1127 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0139 | 0.3381 | 0.3381 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0062 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1127 | 0.1127 |
Onchocerca volvulus | 0.0365 | 1 | 1 | |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0062 | 0.1127 | 0.1127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.7 nM | Inhibition of [3H]-WIN- 35,428 binding to human dopamine transporter (hDAT) | ChEMBL. | 15546718 |
IC50 (binding) | = 6.7 nM | Displacement of [3H]WIN 35428 from DAT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | = 6.7 nM | Inhibition of [3H]-WIN- 35,428 binding to human dopamine transporter (hDAT) | ChEMBL. | 15546718 |
IC50 (binding) | = 6.7 nM | Displacement of [3H]WIN 35428 from DAT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | > 8 uM | Displacement of [3H]citalopram from SERT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | > 8 uM | Displacement of [3H]citalopram from SERT in rhesus monkey caudate-putamen | ChEMBL. | 17070057 |
IC50 (binding) | = 8.7 uM | Inhibition of [3H]-citalopram binding to human serotonin transporter (hSERT) | ChEMBL. | 15546718 |
IC50 (binding) | = 8.7 uM | Inhibition of [3H]-citalopram binding to human serotonin transporter (hSERT) | ChEMBL. | 15546718 |
Ratio (binding) | = 1300 | Ratio of serotonin and dopamine transporter inhibition | ChEMBL. | 15546718 |
Ratio IC50 (binding) | > 1300 | Selectivity for rhesus monkey DAT over rhesus monkey SERT | ChEMBL. | 17070057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.