Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.0578 | 0.026 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0576 | 0.4879 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0576 | 0.4879 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0576 | 0.4879 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1122 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0576 | 0.4879 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1122 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.0578 | 0.0578 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1122 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1122 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1122 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1122 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1122 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1122 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0465 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0576 | 0.4879 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.0578 | 0.026 |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.0578 | 0.0118 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.0578 | 0.0118 |
Brugia malayi | Sugar transporter family protein | 0.0105 | 0.0465 | 0.0465 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0117 | 0.0578 | 0.0578 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0576 | 0.4879 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1122 | 1 | 1 |
Onchocerca volvulus | 0.0117 | 0.0578 | 0.5 | |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0465 | 0.0144 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | uM | Inhibitory activity against matrix metalloproteinase-9; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | uM | Inhibitory activity against matrix metalloproteinase-12; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | uM | Inhibitory activity against matrix metalloproteinase-1; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | uM | Inhibitory activity against matrix metalloproteinase-2; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | NA 0 uM | Inhibitory activity against matrix metalloproteinase-1; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | NA 0 uM | Inhibitory activity against matrix metalloproteinase-2; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | NA 0 uM | Inhibitory activity against matrix metalloproteinase-9; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Ki (binding) | NA 0 uM | Inhibitory activity against matrix metalloproteinase-12; NA denotes no activity upto solubility limit | ChEMBL. | 15341955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.