Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0106 | 0.1703 | 0.1989 |
Trichomonas vaginalis | cyclin B, putative | 0.0079 | 0.0984 | 0.539 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | cyclin b3 | 0.0079 | 0.0984 | 0.0984 |
Trichomonas vaginalis | cyclin B, putative | 0.0106 | 0.1703 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.7004 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0984 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.0106 | 0.1703 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0079 | 0.0984 | 0.539 |
Schistosoma mansoni | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0202 | 0.4207 | 0.4207 |
Echinococcus multilocularis | cyclin B | 0.0106 | 0.1703 | 0.1703 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.7004 | 1 |
Schistosoma mansoni | cyclin B | 0.0106 | 0.1703 | 0.1703 |
Echinococcus granulosus | dihydrofolate reductase | 0.0423 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0423 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0202 | 0.4207 | 0.4156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.0388 | 0.1568 |
Trichomonas vaginalis | cyclin B3, putative | 0.0079 | 0.0984 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0504 | 0.0302 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0504 | 0.0504 |
Trichomonas vaginalis | cyclin B, putative | 0.0106 | 0.1703 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.1997 | 0.1827 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0106 | 0.1703 | 0.163 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0388 | 0.0303 |
Trichomonas vaginalis | cyclin D, putative | 0.0079 | 0.0984 | 0.539 |
Echinococcus granulosus | cyclins | 0.0079 | 0.0984 | 0.0984 |
Trichomonas vaginalis | cyclins, putative | 0.0106 | 0.1703 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0383 | 0.0383 |
Echinococcus multilocularis | cyclin b3 | 0.0079 | 0.0984 | 0.0984 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.7004 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0106 | 0.1703 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0079 | 0.0984 | 0.539 |
Entamoeba histolytica | cyclin, putative | 0.0106 | 0.1703 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0106 | 0.1703 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0106 | 0.1703 | 0.1989 |
Brugia malayi | Dihydrofolate reductase | 0.0423 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0106 | 0.1703 | 0.1989 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0308 | 0.7004 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.1997 | 0.1997 |
Echinococcus granulosus | cyclins | 0.0079 | 0.0984 | 0.0984 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0423 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.7004 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0106 | 0.1703 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0106 | 0.1703 | 0.163 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0202 | 0.4207 | 0.4084 |
Echinococcus multilocularis | cyclin B3 1 | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | cyclin B | 0.0106 | 0.1703 | 0.1703 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1703 | 0.1527 |
Schistosoma mansoni | dihydrofolate reductase | 0.0423 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0423 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0423 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0106 | 0.1703 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0423 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.1997 | 0.1997 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1703 | 0.1527 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.1997 | 0.1997 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0423 | 1 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus granulosus | cyclins | 0.0079 | 0.0984 | 0.0984 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.1997 | 0.1926 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0117 | 0.1997 | 0.1674 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0208 | 0.0121 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0202 | 0.4207 | 0.4207 |
Echinococcus multilocularis | cyclins | 0.0079 | 0.0984 | 0.0984 |
Schistosoma mansoni | cyclin B3 | 0.0202 | 0.4207 | 0.4207 |
Trichomonas vaginalis | cyclins, putative | 0.0106 | 0.1703 | 1 |
Onchocerca volvulus | 0.0117 | 0.1997 | 1 | |
Trypanosoma cruzi | cyclin 6, putative | 0.0106 | 0.1703 | 0.1989 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0308 | 0.7004 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0106 | 0.1703 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 418 nM | In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay | ChEMBL. | 15482909 |
IC50 (functional) | = 418 nM | In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay | ChEMBL. | 15482909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.