Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | 1.6 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for protective index in subcutaneous metrazol test | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 15 min in rats;+means 25% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 30 min in rats; ++ means 50% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 1 hr in rats; +++ means 75% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 2 hr in rats; ++++ means 100% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 30 mg/kg dose after 4 hr in rats; + means 25% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 30 min in rats; ++ means 50% of the animals protected | ChEMBL. | 15294003 |
Activity (functional) | - 0 | Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 1 hr in rats; - means No protection | ChEMBL. | 15294003 |
Activity (functional) | - 0 | Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 2 hr in rats; - means No protection | ChEMBL. | 15294003 |
Activity (functional) | - 0 | Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 4 hr in rats; -means No protection | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 h after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 1 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 300 mg/kg; 1/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 1 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 4 h after the drug administered with dose of 300 mg/kg; 1/1= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 3 | Anti convulsant activity of the compound administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 100 mg/kg; 3/3= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | = 3 | Anti convulsant activity of the compound administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 3/5= No of animals protected /No of animals tested | ChEMBL. | 15294003 |
Activity (functional) | 5.9 | Quantitative Anticonvulsant activity of the compound administered orally to rat for protective index in subcutaneous metrazol test | ChEMBL. | 15294003 |
Anticonvulsant Activity (functional) | - 0 | Toxicity of the compound after oral administration of 30 mg/kg dose in rats; - means No toxicity | ChEMBL. | 15294003 |
Anticonvulsant Activity (functional) | 0 | Anticonvulsant activity of the compound after oral administration of 50 mg/kg dose after 15 min in rats; +++ means 75% of the animals protected | ChEMBL. | 15294003 |
clogP | = 1.53 | Calculated partition coefficient (clogP) | ChEMBL. | 15294003 |
ED50 (functional) | = 29 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered orally to rat at maximal electro shock test; the interval in parenthesis stands for 95% confidence interval | ChEMBL. | 15294003 |
ED50 (functional) | = 90 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for maximal electro shock test ; The interval in parenthesis stands for 95% confidence interval | ChEMBL. | 15294003 |
ED50 (functional) | = 90 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for maximal electro shock test ; The interval in parenthesis stands for 95% confidence interval | ChEMBL. | 15294003 |
ED50 (functional) | = 90 mg kg-1 | Anticonvulsant activity in Mus musculus (mouse) assessed as inhibition of maximal electroshock-induced seizure | ChEMBL. | No reference |
ED50 (functional) | = 92 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered orally to rat for subcutaneous metrazol test | ChEMBL. | 15294003 |
ED50 (functional) | = 125 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for subcutaneous metrazol test | ChEMBL. | 15294003 |
ED50 (functional) | = 125 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for subcutaneous metrazol test | ChEMBL. | 15294003 |
Ratio (functional) | = 1.9 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for protective index in maximal electro shock test;TD50/ED50 | ChEMBL. | 15294003 |
Ratio (functional) | = 18.5 | Quantitative Anticonvulsant activity of the compound administered orally to rat for protective index in maximal electro shock test;TD50/ED50 | ChEMBL. | 15294003 |
TD50 (ADMET) | = 168 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered intraperitoneally to mouse for toxicity | ChEMBL. | 15294003 |
TD50 (ADMET) | = 538 mg kg-1 | Quantitative Anticonvulsant activity of the compound administered orally to rat for toxicity | ChEMBL. | 15294003 |
Toxicity (ADMET) | - 0 | Toxicity of the compound after oral administration of 50 mg/kg dose in rats; - means No toxicity | ChEMBL. | 15294003 |
Toxicity (ADMET) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 30 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested | ChEMBL. | 15294003 |
Toxicity (functional) | = 0 | Anticonvulsant activity of the compound administered intra-peritoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg | ChEMBL. | 15294003 |
Toxicity (ADMET) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 100 mg/kg; 0/8= No of animals exhibiting toxicity /No of animals tested | ChEMBL. | 15294003 |
Toxicity (ADMET) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 100 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested | ChEMBL. | 15294003 |
Toxicity (ADMET) | = 0 | Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 0.5 h with dose of 300 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested | ChEMBL. | 15294003 |
Toxicity (ADMET) | = 1 | Anti convulsant activity of the compound administered intra peritoneally to mouse for toxicity at 4 hr with dose of 300 mg/kg; 1/2= No of animals exhibiting toxicity /No of animals tested | ChEMBL. | 15294003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.