Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.0536 | 0.5596 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0536 | 0.5596 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0536 | 0.5596 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0704 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0536 | 0.5596 | 0.5 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0536 | 0.5596 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0536 | 0.5596 | 0.5 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Treponema pallidum | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0536 | 0.5596 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0536 | 0.5596 | 0.5 |
Trypanosoma brucei | phospholipase A1, putative | 0.0704 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0536 | 0.5596 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0704 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0536 | 0.5596 | 0.5 |
Leishmania major | phospholipase A1, putative | 0.0704 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0536 | 0.5596 | 0.5099 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0704 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0536 | 0.5596 | 0.5 |
Onchocerca volvulus | 0.0704 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 18 % | Percent inhibition of [3H]-FPP incorporation into H-ras CVLS by farnesyltransferase at 1.1 uM | ChEMBL. | 15501060 |
Inhibition (binding) | = 18 % | Percent inhibition of [3H]-FPP incorporation into H-ras CVLS by farnesyltransferase at 1.1 uM | ChEMBL. | 15501060 |
Inhibition (binding) | = 27 % | Percent inhibition of [3H]-FPP incorporation into H-ras CVLS by farnesyltransferase at 1.1 uM | ChEMBL. | 15501060 |
Inhibition (binding) | = 27 % | Percent inhibition of [3H]-FPP incorporation into H-ras CVLS by farnesyltransferase at 1.1 uM | ChEMBL. | 15501060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.