TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.341 | Formula: C19H15N3O3
H donors: 3 H acceptors: 2 LogP: 2.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)NC1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2
InChi: 1S/C19H15N3O3/c1-25-12-6-4-5-11(9-12)21-17-16(18(23)22-19(17)24)14-10-20-15-8-3-2-7-13(14)15/h2-10,20H,1H3,(H2,21,22,23,24)
InChiKey: PIXFHJDLMZCCNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.4315	0.4293
Brugia malayi	Dopamine receptor	0.0035	0.4315	0.5228
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.4315	0.4293
Schistosoma mansoni	biogenic amine receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.4315	0.5432
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.4315	0.5228
Echinococcus granulosus	neuropeptide receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Schistosoma mansoni	atypical protein kinase C	0.0018	0.1328	0.1293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.4315	0.4293
Brugia malayi	sulfakinin receptor protein	0.0035	0.4315	0.5228
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	histamine h1 receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	serine/threonine protein kinase	0.0067	1	1
Echinococcus granulosus	protein kinase c epsilon type	0.0019	0.1595	0.1562
Schistosoma mansoni	neuropeptide receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.4315	0.4293
Brugia malayi	Melatonin receptor type 1A	0.0035	0.4315	0.5228
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.4315	0.4293
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.4315	0.4293
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	fmrfamide receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	opsin-like receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.4315	0.4293
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.4315	0.4293
Brugia malayi	protein kinase C II.	0.0019	0.1595	0.1903
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.4315	0.4293
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Brugia malayi	RE15519p	0.0035	0.4315	0.5228
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.4315	0.4293
Echinococcus multilocularis	protein kinase c epsilon type	0.0019	0.1595	0.1562
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	amine GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.4315	0.5228
Echinococcus multilocularis	protein kinase c iota type	0.0018	0.1328	0.1293
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.4315	0.4293
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.4315	0.4293
Entamoeba histolytica	protein kinase, putative	0.001	0.0039	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.4315	0.4293
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	somatostatin receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0055	0.791	1
Onchocerca volvulus		0.0035	0.4315	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.4315	0.5432
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	hypothetical protein	0.0035	0.4315	0.4293
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Echinococcus granulosus	sex peptide receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.4315	0.4293
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.4315	0.5228
Schistosoma mansoni	hypothetical protein	0.0035	0.4315	0.4293
Brugia malayi	Protein kinase c protein 2	0.0057	0.8217	1
Brugia malayi	neuropeptide F receptor	0.0035	0.4315	0.5228
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.4315	0.5228
Entamoeba histolytica	protein kinase, putative	0.001	0.0039	0.5
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.4315	0.5432
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.4315	0.4293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	g protein coupled receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	biogenic amine receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0035	0.4315	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.4315	0.5228
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	opsin-like receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0049	0.6929	0.8753
Brugia malayi	G-protein coupled receptor	0.0035	0.4315	0.5228
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.4315	0.4293
Trypanosoma brucei	rac serine-threonine kinase, putative	0.001	0.0039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.4315	0.5432
Toxoplasma gondii	AGC kinase	0.001	0.0039	0.5
Schistosoma mansoni	neuropeptide receptor	0.0035	0.4315	0.4293
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0035	0.4315	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Brugia malayi	GnHR receptor homolog	0.0035	0.4315	0.5228
Echinococcus multilocularis	RNA directed DNA polymerase	0.0048	0.6622	0.6609
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.4315	0.5228
Echinococcus granulosus	hypothetical protein	0.0035	0.4315	0.4293
Brugia malayi	larval opioid receptor	0.0035	0.4315	0.5228
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.4315	0.4293
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Schistosoma mansoni	amine GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	g protein coupled receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	myosin xvIII	0.0035	0.4315	0.4293
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0019	0.1595	0.1977
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.4315	0.5432
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0067	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Schistosoma mansoni	serine/threonine protein kinase	0.0067	1	1
Brugia malayi	G protein-coupled receptor	0.0035	0.4315	0.5228
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus granulosus	neuropeptide receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0048	0.6622	0.8363
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.1595	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.4315	0.4293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	g protein coupled receptor	0.0035	0.4315	0.4293
Brugia malayi	Dopamine receptor protein 2	0.0035	0.4315	0.5228
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.4315	0.4293
Brugia malayi	Serotonin receptor	0.0035	0.4315	0.5228
Echinococcus granulosus	protein kinase C gamma type	0.0059	0.8712	0.8707
Schistosoma mansoni	opsin-like receptor	0.0035	0.4315	0.4293
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Brugia malayi	Dopamine receptor protein 1	0.0035	0.4315	0.5228
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Brugia malayi	Serotonin receptor	0.0035	0.4315	0.5228
Echinococcus granulosus	allatostatin A receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.4315	0.4293
Brugia malayi	putative neuropeptide receptor	0.0035	0.4315	0.5228
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Echinococcus multilocularis	serotonin receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	somatostatin receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.4315	0.4293
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.4315	0.4293
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.4315	0.5228
Echinococcus granulosus	serotonin receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	amine GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0048	0.6622	0.6609
Schistosoma mansoni	amine GPCR	0.0035	0.4315	0.4293
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.4315	0.4293
Brugia malayi	ORL1-like opioid receptor	0.0035	0.4315	0.5228
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.4315	0.4293
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.4315	0.4293
Schistosoma mansoni	neuropeptide receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	allatostatin A receptor	0.0035	0.4315	0.4293
Brugia malayi	G-protein coupled receptor	0.0035	0.4315	0.5228
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.4315	0.4293
Schistosoma mansoni	adenoreceptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.4315	0.5432
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	hypothetical protein	0.0035	0.4315	0.4293
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.4315	0.4293
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.4315	0.4293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Echinococcus granulosus	orexin receptor type 2	0.0035	0.4315	0.4293
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.4315	0.4293
Onchocerca volvulus		0.0035	0.4315	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.4315	0.5432
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.4315	0.4293
Schistosoma mansoni	hypothetical protein	0.0035	0.4315	0.4293
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.4315	0.4293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.4315	0.4293
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	serotonin receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.4315	0.4293
Echinococcus multilocularis	sex peptide receptor	0.0035	0.4315	0.4293
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	protein kinase c iota type	0.0018	0.1328	0.1293
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.4315	0.4293
Brugia malayi	AKH receptor	0.0035	0.4315	0.5228
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Entamoeba histolytica	protein kinase, putative	0.001	0.0039	0.5
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0039	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.4315	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.4315	0.4293
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.4315	0.5228
Schistosoma mansoni	amine GPCR	0.0035	0.4315	0.4293
Brugia malayi	neuropeptide F receptor	0.0035	0.4315	0.5228
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.4315	0.4293
Onchocerca volvulus		0.0035	0.4315	0.5
Echinococcus multilocularis	serine threonine protein kinase	0.0059	0.8712	0.8707
Schistosoma mansoni	biogenic amine receptor	0.0035	0.4315	0.4293
Entamoeba histolytica	protein kinase, putative	0.001	0.0039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Brugia malayi	hypothetical protein	0.0035	0.4315	0.5228
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.4315	0.5432
Schistosoma mansoni	neuropeptide receptor	0.0035	0.4315	0.4293
Echinococcus granulosus	RNA directed DNA polymerase	0.0048	0.6622	0.6609
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.4315	0.5228
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.4315	0.4293
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.4315	0.5432
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.4315	0.4293

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.12	Inhibition of PKCbeta2 (unknown origin)	ChEMBL.	No reference
IC50 (binding)	= 747 nM	Inhibitory concentration against recombinant human Protein kinase C beta 2	ChEMBL.	15380221
IC50 (binding)	= 747 nM	Inhibitory concentration against recombinant human Protein kinase C beta 2	ChEMBL.	15380221
IC50 (binding)	= 747 nM	Inhibition of PKCbeta2 (unknown origin)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL186901

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 325380