Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0363 | 0.4718 | 0.711 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0225 | 0.2309 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0363 | 0.4718 | 0.711 |
Brugia malayi | Dihydrofolate reductase | 0.0193 | 0.1748 | 0.2635 |
Echinococcus granulosus | solute carrier family 5 | 0.0363 | 0.4718 | 0.711 |
Mycobacterium ulcerans | thymidylate synthase | 0.0473 | 0.6635 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0225 | 0.2309 | 0.1148 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0665 | 1 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.4718 | 0.711 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0363 | 0.4718 | 0.711 |
Echinococcus granulosus | thymidylate synthase | 0.0473 | 0.6635 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0665 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0473 | 0.6635 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0363 | 0.4718 | 0.711 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0665 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0225 | 0.2309 | 0.348 |
Brugia malayi | dihydrofolate reductase family protein | 0.0193 | 0.1748 | 0.2635 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0193 | 0.1748 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0665 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0473 | 0.6635 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0363 | 0.4718 | 0.711 |
Schistosoma mansoni | dihydrofolate reductase | 0.0193 | 0.1748 | 0.2635 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0473 | 0.6635 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0473 | 0.6635 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0193 | 0.1748 | 0.2635 |
Onchocerca volvulus | 0.0473 | 0.6635 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0665 | 1 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.4718 | 0.711 |
Echinococcus granulosus | dihydrofolate reductase | 0.0193 | 0.1748 | 0.2635 |
Brugia malayi | thymidylate synthase | 0.0473 | 0.6635 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0363 | 0.4718 | 0.711 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0473 | 0.6635 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0193 | 0.1748 | 0.2635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 0.02 uM | In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2 | ChEMBL. | 15380212 |
Ki (functional) | = 0.02 uM | In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2 | ChEMBL. | 15380212 |
Ki (functional) | = 3.75 uM | In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1 | ChEMBL. | 15380212 |
Ki (functional) | = 3.75 uM | In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1 | ChEMBL. | 15380212 |
Ratio (functional) | = 129.3 | Ratio of Ki for sodium glucose co-transporter 1 and sodium glucose co-transporter 2 | ChEMBL. | 15380212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.