TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.501 | Formula: C25H28N2O4
H donors: 1 H acceptors: 4 LogP: 5 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCCCCCOc1ccc(cc1C(=O)c1ccc(cc1)n1cncc1)C
InChi: 1S/C25H28N2O4/c1-19-8-13-23(31-16-6-4-2-3-5-7-24(28)29)22(17-19)25(30)20-9-11-21(12-10-20)27-15-14-26-18-27/h8-15,17-18H,2-7,16H2,1H3,(H,28,29)
InChiKey: DNPVWBOTCIDFDX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0657	0.0706	0.112
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0159	0.0103	0.5
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0226	0.0184	0.0249
Giardia lamblia	hypothetical protein	0.0226	0.0184	0.5
Loa Loa (eye worm)	hypothetical protein	0.4243	0.5048	0.5048
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.4469	0.5321	0.5321
Onchocerca volvulus		0.059	0.0625	0.5
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0226	0.0184	0.1571
Toxoplasma gondii	GAF domain-containing protein	0.0586	0.062	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.0184	0.1061
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.1243	0.1415	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0226	0.0184	0.1061
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0114	0.0049	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0586	0.062	0.3649
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0184	0.0184
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0226	0.0184	0.1061
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0883	0.098	0.5787
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0657	0.0706	0.1208
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0226	0.0184	0.0336
Echinococcus granulosus	mitogen activated protein kinase 11	0.4607	0.5488	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Leishmania major	hypothetical protein, conserved	0.0226	0.0184	0.0151
Echinococcus multilocularis	mitogen activated protein kinase 14	0.4607	0.5488	1
Echinococcus multilocularis	carboxylesterase 5A	0.3494	0.4141	0.7545
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0226	0.0184	0.1571
Echinococcus multilocularis	mitogen activated protein kinase 11	0.4607	0.5488	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1469	0.1689	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0226	0.0184	0.0201
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0586	0.062	0.3938
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.4607	0.5488	1
Giardia lamblia	Hypothetical protein	0.0226	0.0184	0.5
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0226	0.0184	0.0336
Schistosoma mansoni	BC026374 protein (S09 family)	0.059	0.0625	0.1293
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0812	0.0894	0.1553
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.3494	0.4141	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.059	0.0625	0.3681
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1318	0.1507	0.2745
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.059	0.0625	0.1139
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1061
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1571
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0159	0.0103	0.0188
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0226	0.0184	0.5
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0226	0.0184	0.1061
Brugia malayi	putative amidase	0.0159	0.0103	0.0103
Echinococcus multilocularis	acetylcholinesterase	0.3494	0.4141	0.7545
Echinococcus multilocularis	acetylcholinesterase	0.3494	0.4141	0.7545
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Leishmania major	hypothetical protein, conserved	0.0226	0.0184	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0586	0.062	0.3649
Plasmodium falciparum	phosphodiesterase delta, putative	0.0226	0.0184	0.1571
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.0184	0.1061
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0883	0.098	0.5787
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.4607	0.5488	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.059	0.0625	0.3979
Loa Loa (eye worm)	acetylcholinesterase 1	0.3494	0.4141	0.4141
Loa Loa (eye worm)	PDE1B protein	0.0226	0.0184	0.0184
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.059	0.0625	0.1293
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0226	0.0184	0.0184
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1318	0.1507	0.2745
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.4607	0.5488	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Echinococcus multilocularis	mitogen activated protein kinase 11	0.4607	0.5488	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0657	0.0706	0.4595
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0159	0.0103	0.0188
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0111	0.0045	0.855
Brugia malayi	Carboxylesterase family protein	0.059	0.0625	0.0625
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Schistosoma mansoni	amidase	0.1318	0.1507	0.3476
Trypanosoma cruzi	amidase, putative	0.0159	0.0103	0.01
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0812	0.0894	0.1553
Onchocerca volvulus		0.059	0.0625	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0192	0.0142	0.0142
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1318	0.1507	0.2745
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0226	0.0184	0.0336
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1571
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0184	0.0184
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0812	0.0894	0.1468
Onchocerca volvulus		0.059	0.0625	0.5
Loa Loa (eye worm)	carboxylesterase	0.059	0.0625	0.0625
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0215	0.0171	0.0311
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1469	0.1689	1
Loa Loa (eye worm)	hypothetical protein	0.1318	0.1507	0.1507
Brugia malayi	hypothetical protein	0.059	0.0625	0.0625
Toxoplasma gondii	hypothetical protein	0.0586	0.062	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Plasmodium vivax	phosphodiesterase gamma, putative	0.0226	0.0184	0.1571
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0657	0.0706	0.1208
Schistosoma mansoni	gliotactin	0.059	0.0625	0.1293
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1571
Mycobacterium leprae	conserved hypothetical protein	0.0586	0.062	1
Trichomonas vaginalis	conserved hypothetical protein	0.0586	0.062	0.3649
Onchocerca volvulus		0.059	0.0625	0.5
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0226	0.0184	0.1061
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0226	0.0184	0.0201
Schistosoma mansoni	acetylcholinesterase	0.059	0.0625	0.1293
Onchocerca volvulus		0.059	0.0625	0.5
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Loa Loa (eye worm)	hypothetical protein	0.2298	0.2692	0.2692
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0226	0.0184	0.0151
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0226	0.0184	0.1061
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0226	0.0184	0.0336
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0226	0.0184	0.0151
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Echinococcus multilocularis	neuroligin	0.059	0.0625	0.1139
Echinococcus multilocularis	para nitrobenzyl esterase	0.059	0.0625	0.1139
Brugia malayi	Carboxylesterase family protein	0.059	0.0625	0.0625
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0226	0.0184	0.0249
Plasmodium falciparum	GAF domain-related protein, putative	0.0586	0.062	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0812	0.0894	0.1468
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.4607	0.5488	0.5488
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0215	0.0171	0.0311
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0812	0.0894	0.5275
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0226	0.0184	0.0336
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0812	0.0894	0.1628
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0812	0.0894	0.1958
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0184	0.0184
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.4469	0.5321	0.9697
Trypanosoma brucei	hypothetical protein, conserved	0.0226	0.0184	0.0151
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0226	0.0184	0.0249
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0812	0.0894	0.5275
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0226	0.0184	0.0336
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0159	0.0103	0.0188
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.059	0.0625	0.3979
Brugia malayi	P38 map kinase family protein 2	0.4607	0.5488	0.5488
Echinococcus granulosus	acetylcholinesterase	0.3494	0.4141	0.7545
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0226	0.0184	0.1061
Loa Loa (eye worm)	amidase	0.0159	0.0103	0.0103
Brugia malayi	Carboxylesterase family protein	0.3494	0.4141	0.4141
Echinococcus granulosus	acetylcholinesterase	0.3494	0.4141	0.7545
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0114	0.0049	0.0257
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0226	0.0184	0.0184
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0226	0.0184	0.0336
Echinococcus granulosus	BC026374 protein S09 family	0.059	0.0625	0.1139
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1571
Echinococcus granulosus	mitogen activated protein kinase 14	0.4607	0.5488	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.059	0.0625	0.3979
Echinococcus granulosus	para nitrobenzyl esterase	0.059	0.0625	0.1139
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0226	0.0184	0.0249
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0226	0.0184	0.0184
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0226	0.0184	0.0201
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.4469	0.5321	0.9697
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0226	0.0184	0.0151
Brugia malayi	amidase	0.1318	0.1507	0.1507
Brugia malayi	Carboxylesterase family protein	0.3494	0.4141	0.4141
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Trichomonas vaginalis	conserved hypothetical protein	0.0586	0.062	0.3649
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.059	0.0625	0.1293
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0812	0.0894	0.1553
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0812	0.0894	0.1628
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0812	0.0894	0.5275
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0226	0.0184	0.0336
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0226	0.0184	0.0336
Schistosoma mansoni	fatty-acid amide hydrolase	0.1318	0.1507	0.3476
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Echinococcus multilocularis	mitogen activated protein kinase 14	0.4607	0.5488	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0226	0.0184	0.0336
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.2298	0.2692	0.2692
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.4607	0.5488	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.1469	0.1689	1
Loa Loa (eye worm)	hypothetical protein	0.3657	0.4338	0.4338
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1061
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0159	0.0103	0.0188
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.059	0.0625	0.3681
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0226	0.0184	0.0336
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0226	0.0184	0.1571
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Mycobacterium ulcerans	putative regulatory protein	0.0586	0.062	0.3938
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0114	0.0049	0.0257
Toxoplasma gondii	hypothetical protein	0.0586	0.062	1
Toxoplasma gondii	hypothetical protein	0.0586	0.062	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1061
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0226	0.0184	0.0184
Schistosoma mansoni	neuroligin 3 (S09 family)	0.059	0.0625	0.1293
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.059	0.0625	0.1139
Brugia malayi	Amidase family protein	0.0159	0.0103	0.0103
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1571
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.2298	0.2692	0.6413
Echinococcus granulosus	neuroligin	0.059	0.0625	0.1139
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0159	0.0103	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Echinococcus multilocularis	BC026374 protein (S09 family)	0.059	0.0625	0.1139
Loa Loa (eye worm)	carboxylesterase	0.3494	0.4141	0.4141
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.0151
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.0657	0.0706	0.112
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0215	0.0171	0.0168
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0812	0.0894	0.5275
Loa Loa (eye worm)	hypothetical protein	0.3494	0.4141	0.4141
Loa Loa (eye worm)	amidase	0.0159	0.0103	0.0103
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.1469	0.1689	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0226	0.0184	0.1061
Brugia malayi	Carboxylesterase family protein	0.059	0.0625	0.0625
Loa Loa (eye worm)	carboxylesterase	0.059	0.0625	0.0625
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.8334	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.0049	1
Plasmodium vivax	hypothetical protein, conserved	0.0586	0.062	1
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0101	0.0032	0.0032
Brugia malayi	Carboxylesterase family protein	0.059	0.0625	0.0625
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0226	0.0184	0.0151
Brugia malayi	Amidase family protein	0.0159	0.0103	0.0103
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.1243	0.1415	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.059	0.0625	0.1293
Mycobacterium ulcerans	putative regulatory protein	0.0586	0.062	0.3938
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0226	0.0184	0.0184
Trypanosoma cruzi	amidase, putative	0.0159	0.0103	0.01
Echinococcus granulosus	carboxylesterase 5A	0.3494	0.4141	0.7545
Trypanosoma cruzi	hypothetical protein, conserved	0.0226	0.0184	0.0249
Mycobacterium tuberculosis	Carboxylesterase LipT	0.059	0.0625	0.3979
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0159	0.0103	0.5
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0226	0.0184	0.0249
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1318	0.1507	0.2745
Loa Loa (eye worm)	hypothetical protein	0.059	0.0625	0.0625
Loa Loa (eye worm)	hypothetical protein	0.3494	0.4141	0.4141
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0226	0.0184	0.0336

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4797 nM	Inhibitory activity against 20-Hydroxy-5,8,11,14-eicosatetraenoic acid synthase from arachidonic acid in human renal microsome	ChEMBL.	15454216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 325910