Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Echinococcus multilocularis | acetylcholinesterase | 0.0895 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0151 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Echinococcus multilocularis | acetylcholinesterase | 0.0895 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | carboxylesterase | 0.0895 | 1 | 1 |
Onchocerca volvulus | 0.0151 | 0.0638 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0151 | 0.0638 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0895 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.0638 | 0.0638 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0895 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0895 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0895 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.0638 | 0.0638 |
Echinococcus granulosus | carboxylesterase 5A | 0.0895 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0895 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0895 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0151 | 0.0638 | 0.0638 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.0638 | 0.0638 |
Onchocerca volvulus | 0.0151 | 0.0638 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0895 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Echinococcus granulosus | neuroligin | 0.0151 | 0.0638 | 0.0638 |
Onchocerca volvulus | 0.0151 | 0.0638 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.0638 | 0.0638 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Schistosoma mansoni | gliotactin | 0.0151 | 0.0638 | 0.0638 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0151 | 0.0638 | 0.0638 |
Echinococcus multilocularis | neuroligin | 0.0151 | 0.0638 | 0.0638 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0151 | 0.0638 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.0638 | 0.0638 |
Onchocerca volvulus | 0.0151 | 0.0638 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0895 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.0638 | 0.0638 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0151 | 0.0638 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Onchocerca volvulus | 0.0151 | 0.0638 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0638 | 0.0638 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.0638 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0151 | 0.0638 | 0.0638 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 73 nM | Inhibitory activity against 20-Hydroxy-5,8,11,14-eicosatetraenoic acid synthase from arachidonic acid in human renal microsome | ChEMBL. | 15454216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.