Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0167 | 0.0167 |
Brugia malayi | steroid hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | FTZ F1 alpha | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0167 | 0.0182 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0302 | 0.1972 | 0.5 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.0398 | 0.0457 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0302 | 0.1972 | 0.1972 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.0398 | 0.0457 |
Plasmodium falciparum | glyoxalase I | 0.1306 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0105 | 0.0398 | 0.0435 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0105 | 0.0398 | 0.0398 |
Onchocerca volvulus | Putative protein | 0.0302 | 0.1972 | 0.1639 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | ecdysteroid receptor | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.0398 | 0.0457 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0105 | 0.0398 | 0.0457 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1142 | 0.8692 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0105 | 0.0398 | 0.0435 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0167 | 0.0192 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.0398 | 0.0435 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1198 | 0.9137 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1306 | 1 | 0.5 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1306 | 1 | 0.5 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.1306 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1306 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0167 | 0.0167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0105 | 0.0398 | 0.0435 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0105 | 0.0398 | 0.0457 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0302 | 0.1972 | 0.2158 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium tuberculosis | Conserved protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0105 | 0.0398 | 0.0435 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0302 | 0.1972 | 0.1972 |
Schistosoma mansoni | nuclear hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0105 | 0.0398 | 0.0435 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0457 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0105 | 0.0398 | 0.0457 |
Mycobacterium leprae | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | nuclear receptor NHR-88 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0105 | 0.0398 | 0.0435 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium tuberculosis | Conserved protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0105 | 0.0398 | 0.0398 |
Plasmodium vivax | glyoxalase I, putative | 0.1306 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1198 | 0.9137 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0167 | 0.0167 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | gynecophoral canal protein | 0.0302 | 0.1972 | 0.2158 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0167 | 0.0167 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0105 | 0.0398 | 0.0457 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0105 | 0.0398 | 0.0398 |
Toxoplasma gondii | glyoxalase I, putative | 0.1306 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0167 | 0.0167 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0435 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0457 |
Schistosoma mansoni | coup transcription factor | 0.0105 | 0.0398 | 0.0435 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.1306 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.0398 | 0.0398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP (ADMET) | = 3.22 | Hydrophobicity | ChEMBL. | 15267244 |
IC50 (binding) | = 34 uM | Inhibitory effect on human reticulocyte 15-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | = 34 uM | Inhibitory effect on human reticulocyte 15-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | > 100 uM | Inhibitory effect on human platelet 12-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | > 100 uM | Inhibitory effect on soybean 15-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | > 100 uM | Inhibitory effect on human platelet 12-lipoxygenase | ChEMBL. | 15267244 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.