Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Echinococcus granulosus | cathepsin b | 0.0149 | 0.8293 | 0.8293 |
Echinococcus granulosus | cathepsin b | 0.0149 | 0.8293 | 0.8293 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.002 | 0.0227 | 0.0274 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.5367 | 0.6472 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0994 | 0.0952 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0072 | 0.3499 | 1 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0028 | 0.0713 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0072 | 0.3499 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0227 | 0.0649 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 0.8293 | 0.8293 |
Toxoplasma gondii | cathepsin B | 0.0052 | 0.2229 | 0.544 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0994 | 0.0994 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 0.8293 | 0.8293 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0994 | 0.0994 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3343 | 0.3864 |
Echinococcus multilocularis | cathepsin b | 0.0149 | 0.8293 | 0.8293 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0028 | 0.0713 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0227 | 0.0649 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0052 | 0.2229 | 0.6369 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0994 | 0.0994 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Onchocerca volvulus | Cathepsin L homolog | 0.0028 | 0.0713 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2229 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0028 | 0.0713 | 0.0713 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0028 | 0.0713 | 0.2039 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0072 | 0.3499 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0994 | 0.0994 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.3499 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0072 | 0.3499 | 0.3499 |
Loa Loa (eye worm) | cathepsin B | 0.0052 | 0.2229 | 0.2482 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0227 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.002 | 0.0227 | 0.0274 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0994 | 0.0994 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0149 | 0.8293 | 0.8293 |
Loa Loa (eye worm) | cysteine protease | 0.0028 | 0.0713 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Brugia malayi | beta-NAC-like protein | 0.0072 | 0.3499 | 0.422 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Loa Loa (eye worm) | fibroinase | 0.0028 | 0.0713 | 0.0603 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0149 | 0.8293 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0149 | 0.8293 | 0.8293 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.8293 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0149 | 0.8293 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.3499 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Leishmania major | basic transcription factor 3a, putative | 0.0072 | 0.3499 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0227 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0028 | 0.0713 | 0.2039 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.0713 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0227 | 0.0227 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Loa Loa (eye worm) | ICD-1 protein | 0.0072 | 0.3499 | 0.4057 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.3499 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0052 | 0.2229 | 0.2229 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Echinococcus granulosus | transcription factor btf3 | 0.0072 | 0.3499 | 0.3499 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0052 | 0.2229 | 0.2688 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0028 | 0.0713 | 0.086 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0052 | 0.2229 | 0.544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0028 | 0.0713 | 0.0713 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2229 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0994 | 0.0994 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0028 | 0.0713 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0072 | 0.3499 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0028 | 0.0713 | 0.0713 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0072 | 0.3499 | 0.422 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0994 | 0.0994 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0072 | 0.3499 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Schistosoma mansoni | transcription factor btf3 | 0.0072 | 0.3499 | 0.3499 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0994 | 0.0994 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.3499 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0994 | 0.0994 |
Echinococcus granulosus | cathepsin l1 | 0.0028 | 0.0713 | 0.0713 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0994 | 0.1199 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0028 | 0.0713 | 0.2039 |
Echinococcus multilocularis | cysteine protease | 0.0028 | 0.0713 | 0.0713 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0028 | 0.0713 | 0.0713 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.5367 | 0.6373 |
Plasmodium vivax | vivapain-2 | 0.0028 | 0.0713 | 0.2039 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0028 | 0.0713 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.0713 | 0.086 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0072 | 0.3499 | 0.422 |
Brugia malayi | Cathepsin L-like precursor | 0.0028 | 0.0713 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0994 | 0.1199 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2229 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0028 | 0.0713 | 0.0713 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0028 | 0.0713 | 0.0713 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0227 | 0.0227 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.3343 | 0.4032 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0994 | 0.0952 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0149 | 0.8293 | 0.8293 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0028 | 0.0713 | 0.2039 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0028 | 0.0713 | 0.0713 |
Brugia malayi | cathepsin L-like precursor | 0.002 | 0.0227 | 0.0274 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.0713 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0713 | 0.0603 |
Echinococcus multilocularis | cysteine protease | 0.0028 | 0.0713 | 0.0713 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0028 | 0.0713 | 0.086 |
Loa Loa (eye worm) | ctsf protein | 0.0028 | 0.0713 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0028 | 0.0713 | 0.2039 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0028 | 0.0713 | 0.086 |
Onchocerca volvulus | 0.0028 | 0.0713 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.5367 | 0.6373 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.5367 | 0.6472 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0227 | 0.0649 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.3343 | 0.3343 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0052 | 0.2229 | 0.6369 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Echinococcus multilocularis | geminin | 0.0176 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0028 | 0.0713 | 0.2039 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0028 | 0.0713 | 0.2039 |
Onchocerca volvulus | Cathepsin L homolog | 0.0028 | 0.0713 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.0001 M | Inhibiton of [3H]-BRL-43694 binding to rat 5-hydroxytryptamine 3 receptor | ChEMBL. | 8176710 |
IC50 (binding) | > 0.0001 M | Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]-5-HT as radioligand | ChEMBL. | 8176710 |
IC50 (binding) | > 0.0001 M | Displacement of [3H]-spiroperidol from D2 dopamine receptor | ChEMBL. | 8176710 |
IC50 (binding) | > 0.0001 M | Inhibiton of [3H]-BRL-43694 binding to rat 5-hydroxytryptamine 3 receptor | ChEMBL. | 8176710 |
IC50 (binding) | > 0.0001 M | Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]-5-HT as radioligand | ChEMBL. | 8176710 |
IC50 (binding) | > 0.0001 M | Displacement of [3H]-spiroperidol from D2 dopamine receptor | ChEMBL. | 8176710 |
Inhibition (functional) | = 14.7 % | The compound was evaluated for the percentage inhibition in rat aorta stimulated with 30 microM 5-HT and tested at fixed concentration of 10 microM | ChEMBL. | 8176710 |
Inhibition (functional) | = 25.6 % | The compound was evaluated for the percentage inhibition in guinea pig ileum stimulated with 10 microM 5-HT and tested at fixed concentration of 10 microM | ChEMBL. | 8176710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.