Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 3 | References | |
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0143 | 0.1874 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0494 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0104 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0104 | 0.0974 | 0.0045 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0494 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0351 | 0.6686 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0351 | 0.6686 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0494 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0167 | 0.2426 | 0.3628 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0167 | 0.2426 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0104 | 0.0974 | 0.5 |
Brugia malayi | hypothetical protein | 0.0167 | 0.2426 | 0.2542 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0104 | 0.0974 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0104 | 0.0974 | 0.0045 |
Echinococcus granulosus | cyclin dependent kinase | 0.0104 | 0.0974 | 0.1457 |
Mycobacterium ulcerans | thymidylate synthase | 0.0351 | 0.6686 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.0974 | 0.1457 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0351 | 0.6686 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0104 | 0.0974 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0104 | 0.0974 | 0.1457 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0104 | 0.0974 | 0.1457 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0104 | 0.0974 | 0.1457 |
Onchocerca volvulus | 0.0351 | 0.6686 | 0.5 | |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.029 | 0.5283 | 0.7544 |
Brugia malayi | Dihydrofolate reductase | 0.0143 | 0.1874 | 0.1575 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0143 | 0.1874 | 0.2802 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0104 | 0.0974 | 0.1457 |
Giardia lamblia | Kinase, CMGC CDK | 0.0104 | 0.0974 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.029 | 0.5283 | 0.7555 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0351 | 0.6686 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0143 | 0.1874 | 0.2802 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0104 | 0.0974 | 0.0974 |
Echinococcus multilocularis | thymidylate synthase | 0.0351 | 0.6686 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0143 | 0.1874 | 0.2802 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0494 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.0974 | 0.1457 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0104 | 0.0974 | 0.1457 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0167 | 0.2426 | 0.1609 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0143 | 0.1874 | 0.1613 |
Echinococcus granulosus | thymidylate synthase | 0.0351 | 0.6686 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0143 | 0.1874 | 0.2802 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0104 | 0.0974 | 0.0045 |
Loa Loa (eye worm) | thymidylate synthase | 0.0351 | 0.6686 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0104 | 0.0974 | 0.1457 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0104 | 0.0974 | 0.0974 |
Brugia malayi | dihydrofolate reductase family protein | 0.0143 | 0.1874 | 0.1575 |
Schistosoma mansoni | dihydrofolate reductase | 0.0143 | 0.1874 | 0.2802 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0494 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0104 | 0.0974 | 0.1457 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 390 nM | Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay | ChEMBL. | 15482916 |
IC50 (binding) | = 390 nM | Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay | ChEMBL. | 15482916 |
IC50 (binding) | = 997 nM | Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay | ChEMBL. | 15482916 |
IC50 (binding) | = 997 nM | Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay | ChEMBL. | 15482916 |
Ratio (binding) | = 2.6 | Ratio of inhibition of cyclin dependant kinase 2-cyclin E to that of cyclin-dependent kinase 5 | ChEMBL. | 15482916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.