Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Mus musculus | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuropeptides capa receptor | melanin-concentrating hormone receptor 1 | 353 aa | 334 aa | 20.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0185 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0185 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0185 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0185 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0185 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0185 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0185 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0185 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0185 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0185 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0185 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0185 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0185 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0185 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0185 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding assay | ChEMBL. | 15950463 |
IC50 (binding) | = 0.05 uM | Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding assay | ChEMBL. | 15950463 |
IC50 (functional) | = 0.56 uM | Inhibitory concentration required for functional antagonism of MCH mediated Ca+2 release competing human IMR32 cells receptor in a FLIPRTM based assay | ChEMBL. | 15950463 |
IC50 (functional) | = 0.56 uM | Inhibitory concentration required for functional antagonism of MCH mediated Ca+2 release competing human IMR32 cells receptor in a FLIPRTM based assay | ChEMBL. | 15950463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.