Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0143 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0143 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP (ADMET) | = 5.26 | Hydrophobicity | ChEMBL. | 15267244 |
IC50 (ADMET) | > 15 ug ml-1 | Cytotoxicity against rat NBT-T2 cells by MTT method | ChEMBL. | 17311456 |
IC50 (binding) | = 11 uM | Inhibitory effect on human reticulocyte 15-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | = 11 uM | Inhibitory effect on human reticulocyte 15-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | = 47 uM | Inhibitory effect on human platelet 12-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | = 47 uM | Inhibitory effect on human platelet 12-lipoxygenase | ChEMBL. | 15267244 |
IC50 (binding) | > 100 uM | Inhibitory effect on soybean 15-lipoxygenase | ChEMBL. | 15267244 |
IZ (functional) | = 7 mm | Antibacterial activity against Bacillus subtilis at 0.1ug/disk after 24 hrs by agar-plate diffusion assay | ChEMBL. | 17311456 |
IZ (functional) | = 13 mm | Antibacterial activity against Bacillus subtilis at 1 ug/disk after 24 hrs hrs by agar-plate diffusion assay | ChEMBL. | 17311456 |
IZ (functional) | = 16 mm | Antibacterial activity against Bacillus subtilis at 5 ug/disk after 24 hrs hrs by agar-plate diffusion assay | ChEMBL. | 17311456 |
IZ (functional) | = 18 mm | Antibacterial activity against Bacillus subtilis at 10 ug/disk after 24 hrs hrs by agar-plate diffusion assay | ChEMBL. | 17311456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.