TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 633.819 | Formula: C33H55N5O7
H donors: 6 H acceptors: 6 LogP: 3.51 Rotable bonds: 23
Rule of 5 violations (Lipinski): 3
SMILES: COC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)[C@H](C[C@H](C(NC(=O)C(NC(=O)C(N)C)C)Cc1ccccc1)O)CC(C)C
InChi: 1S/C33H55N5O7/c1-18(2)15-24(31(42)37-27(19(3)4)32(43)38-28(20(5)6)33(44)45-9)17-26(39)25(16-23-13-11-10-12-14-23)36-30(41)22(8)35-29(40)21(7)34/h10-14,18-22,24-28,39H,15-17,34H2,1-9H3,(H,35,40)(H,36,41)(H,37,42)(H,38,43)/t21?,22?,24-,25?,26+,27?,28?/m1/s1
InChiKey: CDZSRMLOVAYORE-SSNKYERMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide Y receptor	0.0292	0.1582	0.3146
Entamoeba histolytica	cell division protein kinase 2, putative	0.0206	0.0998	1
Echinococcus granulosus	neuropeptide s receptor	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0093	0.0228	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	serotonin receptor	0.0292	0.1582	0.3146
Brugia malayi	ORL1-like opioid receptor	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Trypanosoma cruzi	cdc2-related kinase 1	0.0182	0.0836	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0798	0.5029	1
Schistosoma mansoni	amine GPCR	0.0292	0.1582	0.1582
Schistosoma mansoni	hypothetical protein	0.0292	0.1582	0.1582
Brugia malayi	Dopamine receptor protein 2	0.0292	0.1582	0.3146
Echinococcus granulosus	g-protein coupled receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	GnHR receptor homolog	0.0292	0.1582	0.3146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0182	0.0836	0.1662
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0292	0.1582	0.1582
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0292	0.1582	0.3146
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0182	0.0836	0.1662
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Trichomonas vaginalis	CMGC family protein kinase	0.0182	0.0836	0.1662
Echinococcus multilocularis	cyclin dependent kinase 9	0.017	0.0751	0.1494
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	cyclin B	0.0093	0.0228	0.0228
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0292	0.1582	0.3146
Echinococcus multilocularis	g protein coupled receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclin B, putative	0.0093	0.0228	0.0453
Brugia malayi	MAP kinase sur-1	0.0798	0.5029	1
Echinococcus multilocularis	orexin receptor type 2	0.0292	0.1582	0.3146
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0182	0.0836	0.1662
Brugia malayi	G-protein coupled receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	cyclin 6, putative	0.0093	0.0228	0.0453
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	fmrfamide receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclins, putative	0.0093	0.0228	0.0453
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0182	0.0836	0.1662
Schistosoma mansoni	serine/threonine protein kinase	0.0182	0.0836	0.0836
Trypanosoma cruzi	cyclin, putative	0.0093	0.0228	0.0453
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Loa Loa (eye worm)	TYRA-2 protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0292	0.1582	0.3146
Brugia malayi	putative neuropeptide receptor NPR1	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0798	0.5029	1
Onchocerca volvulus		0.0292	0.1582	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0182	0.0836	0.1662
Onchocerca volvulus		0.0292	0.1582	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0292	0.1582	0.3146
Brugia malayi	neuropeptide F receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0292	0.1582	0.3146
Echinococcus granulosus	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	AKH receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0798	0.5029	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0292	0.1582	0.3146
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0182	0.0836	0.1662
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0798	0.5029	0.9688
Echinococcus granulosus	biogenic amine 5HT receptor	0.0292	0.1582	0.3146
Brugia malayi	RE15519p	0.0292	0.1582	0.3146
Echinococcus multilocularis	fmrfamide receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	somatostatin receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	cyclin dependent kinase 9	0.0146	0.0589	0.1172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	neuropeptide f receptor 76f	0.0292	0.1582	0.1582
Echinococcus multilocularis	dro:myosuppressin receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0146	0.0589	0.1172
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	calcium activated potassium channel	0.0069	0.0068	0.0135
Brugia malayi	larval opioid receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	cyclin dependent kinase 1	0.0182	0.0836	0.1662
Onchocerca volvulus		0.0292	0.1582	1
Onchocerca volvulus		0.0292	0.1582	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0093	0.0228	0.0453
Onchocerca volvulus		0.0292	0.1582	1
Brugia malayi	neuropeptide F receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclin B, putative	0.0093	0.0228	0.0453
Plasmodium vivax	protein kinase Crk2	0.0182	0.0836	0.5
Echinococcus multilocularis	cyclin dependent kinase 1	0.0182	0.0836	0.1662
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0292	0.1582	0.3146
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0182	0.0836	0.1662
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclins, putative	0.0093	0.0228	0.0453
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0292	0.1582	0.3146
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0292	0.1582	0.3146
Loa Loa (eye worm)	neuropeptide F receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	tm gpcr rhodopsin	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Schistosoma mansoni	biogenic amine receptor	0.0292	0.1582	0.1582
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.0589	0.4695
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0292	0.1582	0.3146
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0292	0.1582	0.3146
Echinococcus granulosus	calcium activated potassium channel	0.0069	0.0068	0.0135
Entamoeba histolytica	cell division protein kinase 2, putative	0.0182	0.0836	0.7895
Brugia malayi	putative neuropeptide receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	somatostatin receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0798	0.5029	1
Schistosoma mansoni	myosin xvIII	0.0292	0.1582	0.1582
Echinococcus multilocularis	mitogen activated protein kinase	0.0798	0.5029	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0798	0.5029	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0182	0.0836	0.1662
Echinococcus multilocularis	neuropeptide receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	neuropeptide receptor A26	0.0292	0.1582	0.3146
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0292	0.1582	0.1582
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0278	0.1488	0.1488
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0798	0.5029	1
Brugia malayi	Protein kinase domain containing protein	0.0182	0.0836	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0292	0.1582	0.3146
Echinococcus granulosus	G protein coupled receptor 139	0.0292	0.1582	0.3146
Echinococcus granulosus	cyclin dependent kinase 1	0.0182	0.0836	0.1662
Echinococcus multilocularis	g protein coupled receptor	0.0292	0.1582	0.3146
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0093	0.0228	0.0453
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Echinococcus multilocularis	neuropeptide receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0292	0.1582	0.1582
Schistosoma mansoni	hypothetical protein	0.0292	0.1582	0.1582
Schistosoma mansoni	neuropeptide receptor	0.0292	0.1582	0.1582
Schistosoma mansoni	amine GPCR	0.0292	0.1582	0.1582
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	cyclin B	0.0093	0.0228	0.0453
Echinococcus granulosus	g protein coupled receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	neuropeptide receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	neuropeptides capa receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0228	0.0453
Echinococcus granulosus	g protein coupled receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	amine GPCR	0.0292	0.1582	0.1582
Trypanosoma brucei	cdc2-related kinase 1	0.0182	0.0836	0.161
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0292	0.1582	0.3146
Schistosoma mansoni	neuropeptide F-like receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0292	0.1582	0.3146
Brugia malayi	Serotonin receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Leishmania major	cyclin	0.0093	0.0228	0.0453
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0182	0.0836	0.1662
Loa Loa (eye worm)	G-protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	tm gpcr rhodopsin	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	neuropeptide receptor A26	0.0292	0.1582	0.3146
Echinococcus granulosus	cyclin dependent kinase	0.0182	0.0836	0.1662
Brugia malayi	follicle stimulating hormone receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0798	0.5029	1
Brugia malayi	G-protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	neuropeptide FF receptor 2	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0292	0.1582	0.1582
Echinococcus multilocularis	sex peptide receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	cyclin dependent kinase 9	0.0146	0.0589	0.1172
Giardia lamblia	Kinase, CMGC CDK	0.0182	0.0836	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0292	0.1582	0.3146
Trypanosoma brucei	mitotic cyclin 6	0.0093	0.0228	0.0439
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	neuropeptide F receptor	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Echinococcus multilocularis	cyclin B	0.0093	0.0228	0.0453
Schistosoma mansoni	hypothetical protein	0.0292	0.1582	0.1582
Brugia malayi	sulfakinin receptor protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Schistosoma mansoni	hypothetical protein	0.0292	0.1582	0.1582
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0093	0.0228	0.0453
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0798	0.5029	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0292	0.1582	0.3146
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0292	0.1582	0.1582
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0292	0.1582	0.3146
Echinococcus granulosus	g protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	neuropeptides capa receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	serotonin receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclins, putative	0.0093	0.0228	0.0453
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	cdc2-related kinase 3	0.0182	0.0836	0.1662
Echinococcus granulosus	dro:myosuppressin receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	G protein coupled receptor 139	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclins, putative	0.0093	0.0228	0.0453
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0798	0.5029	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0798	0.5029	1
Echinococcus granulosus	neuropeptide Y receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	adenoreceptor	0.0292	0.1582	0.1582
Schistosoma mansoni	histamine h1 receptor	0.0292	0.1582	0.1582
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Brugia malayi	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	amine GPCR	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	serine/threonine protein kinase	0.0798	0.5029	0.5029
Schistosoma mansoni	amine GPCR	0.0292	0.1582	0.1582
Echinococcus multilocularis	g-protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	neuropeptide s receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclin B, putative	0.0093	0.0228	0.0453
Brugia malayi	cell division control protein 2 homolog	0.0182	0.0836	0.1662
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0292	0.1582	0.3146
Echinococcus granulosus	7tm_1 domain containing protein	0.0292	0.1582	0.3146
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0798	0.5029	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0292	0.1582	0.1582
Giardia lamblia	Kinase, CMGC CDK	0.0182	0.0836	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0292	0.1582	1
Schistosoma mansoni	kinase	0.0146	0.0589	0.0589
Echinococcus granulosus	orexin receptor type 2	0.0292	0.1582	0.3146
Echinococcus granulosus	mitogen activated protein kinase 3	0.0798	0.5029	1
Echinococcus granulosus	neuropeptide receptor	0.0292	0.1582	0.3146
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0292	0.1582	1
Trypanosoma brucei	protein kinase, putative	0.0822	0.5191	1
Echinococcus multilocularis	g protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0292	0.1582	0.3146
Trypanosoma cruzi	cyclin, putative	0.0093	0.0228	0.0453
Echinococcus granulosus	neuropeptides capa receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	cdc2-related kinase 3	0.0182	0.0836	0.1662
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0292	0.1582	0.3146
Trypanosoma cruzi	cdc2-related kinase 1	0.0182	0.0836	0.1662
Echinococcus multilocularis	fmrfamide receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0768	0.1527
Onchocerca volvulus		0.0292	0.1582	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	7TM GPCR rhodopsin	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	Serotonin receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	opsin-like receptor	0.0292	0.1582	0.1582
Brugia malayi	G protein-coupled receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	cyclin dependent kinase 5	0.0182	0.0836	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	neuropeptide receptor	0.0292	0.1582	0.3146
Echinococcus granulosus	cyclin dependent kinase 5	0.0182	0.0836	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	cyclin dependent kinase	0.0182	0.0836	0.1662
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Onchocerca volvulus		0.0292	0.1582	1
Echinococcus multilocularis	allatostatin A receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	serine/threonine protein kinase	0.0182	0.0836	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0228	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	tm gpcr rhodopsin	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	opsin-like receptor	0.0292	0.1582	0.1582
Echinococcus multilocularis	serotonin receptor	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclin B, putative	0.0093	0.0228	0.0453
Echinococcus granulosus	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Trichomonas vaginalis	cyclin A, putative	0.0093	0.0228	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	sex peptide receptor	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Brugia malayi	Melatonin receptor type 1A	0.0292	0.1582	0.3146
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Trichomonas vaginalis	CMGC family protein kinase	0.0798	0.5029	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0292	0.1582	0.1582
Onchocerca volvulus		0.0093	0.0228	0.144
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0292	0.1582	0.1582
Schistosoma mansoni	opsin-like receptor	0.0292	0.1582	0.1582
Echinococcus granulosus	allatostatin A receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Trypanosoma brucei	cdc2-related kinase 3	0.0182	0.0836	0.161
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0292	0.1582	0.1582
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0292	0.1582	0.1582
Schistosoma mansoni	neuropeptide receptor	0.0292	0.1582	0.1582
Brugia malayi	G protein-coupled receptor F59B2.13	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Brugia malayi	Dopamine receptor protein 1	0.0292	0.1582	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus granulosus	mitogen activated protein kinase	0.0798	0.5029	1
Echinococcus granulosus	cyclin dependent kinase 9	0.017	0.0751	0.1494
Schistosoma mansoni	neuropeptide receptor	0.0292	0.1582	0.1582
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0798	0.5029	1
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.0589	0.0589
Giardia lamblia	Kinase, CMGC MAPK	0.0798	0.5029	1
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0292	0.1582	0.3146
Loa Loa (eye worm)	G-protein coupled receptor	0.0292	0.1582	0.3146
Echinococcus multilocularis	neuropeptide Y receptor	0.0292	0.1582	0.3146
Brugia malayi	Dopamine receptor	0.0292	0.1582	0.3146
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0292	0.1582	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1582	0.3146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146
Plasmodium falciparum	protein kinase 5	0.0182	0.0836	0.5
Brugia malayi	cyclin-dependent kinase 9	0.0146	0.0589	0.1172
Echinococcus multilocularis	neuropeptide Y receptor	0.0292	0.1582	0.3146
Onchocerca volvulus		0.0292	0.1582	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0292	0.1582	0.3146

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.6 nM	Binding affinity towards human immunodeficiency virus type 1 protease determined using continuum electrostatics solvation	ChEMBL.	15509178

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 414632

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 326560