Detailed information for compound 326565

Basic information

Technical information
  • TDR Targets ID: 326565
  • Name: 7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6-fluo ro-1-(4-hydroxyphenyl)-4-oxoquinoline-3-carbo xylic acid
  • MW: 411.426 | Formula: C22H22FN3O4
  • H donors: 3 H acceptors: 4 LogP: 1.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1N[C@H](C)CN(C1)c1cc2c(cc1F)c(=O)c(cn2c1ccc(cc1)O)C(=O)O
  • InChi: 1S/C22H22FN3O4/c1-12-9-25(10-13(2)24-12)20-8-19-16(7-18(20)23)21(28)17(22(29)30)11-26(19)14-3-5-15(27)6-4-14/h3-8,11-13,24,27H,9-10H2,1-2H3,(H,29,30)/t12-,13+
  • InChiKey: OORBGTISECFQAA-BETUJISGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6-fluoro-1-(4-hydroxyphenyl)-4-oxo-quinoline-3-carboxylic acid
  • 7-[(3S,5R)-3,5-dimethyl-1-piperazinyl]-6-fluoro-1-(4-hydroxyphenyl)-4-oxo-3-quinolinecarboxylic acid
  • 7-[(3S,5R)-3,5-dimethylpiperazino]-6-fluoro-1-(4-hydroxyphenyl)-4-keto-quinoline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus tar DNA binding protein 0.007 0.3573 0.3573
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0351 0.0351
Brugia malayi RE15519p 0.003 0.0351 0.0351
Echinococcus multilocularis g protein coupled receptor 0.003 0.0351 0.0351
Brugia malayi GnHR receptor homolog 0.003 0.0351 0.0351
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0351 0.0351
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus serotonin transporter 0.0149 1 1
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi RNA recognition motif domain containing protein 0.007 0.3573 0.3573
Brugia malayi follicle stimulating hormone receptor 0.003 0.0351 0.0351
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.007 0.3573 0.3573
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni opsin-like receptor 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide receptor 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0351 0.0351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide s receptor 0.003 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.007 0.3573 0.3573
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Plasmodium falciparum transporter, putative 0.0025 0 0.5
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Brugia malayi Melatonin receptor type 1A 0.003 0.0351 0.0351
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0 0.5
Brugia malayi Dopamine receptor protein 1 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Onchocerca volvulus 0.0149 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0351 0.0351
Schistosoma mansoni sodium/chloride dependent transporter 0.0149 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0351 0.0351
Echinococcus granulosus sex peptide receptor 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus fmrfamide receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0351 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0 0.5
Schistosoma mansoni hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0351 0.0351
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0351 0.0351
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0351 0.0351
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Schistosoma mansoni adenoreceptor 0.003 0.0351 0.0351
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0351 0.0351
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0351 0.0351
Loa Loa (eye worm) TAR-binding protein 0.007 0.3573 0.3573
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0351 0.0351
Schistosoma mansoni histamine h1 receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.3573 0.3573
Schistosoma mansoni neuropeptide receptor 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis fmrfamide receptor 0.003 0.0351 0.0351
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0351 0.0351
Echinococcus multilocularis tar DNA binding protein 0.007 0.3573 0.3573
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Brugia malayi G-protein coupled receptor 0.003 0.0351 0.0351
Brugia malayi Dopamine receptor 0.003 0.0351 0.0351
Brugia malayi neuropeptide F receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0351 0.0351
Echinococcus multilocularis somatostatin receptor 0.003 0.0351 0.0351
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0351 0.0351
Brugia malayi ORL1-like opioid receptor 0.003 0.0351 0.0351
Echinococcus multilocularis serotonin receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0351 0.0351
Echinococcus granulosus orexin receptor type 2 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0351 0.0351
Plasmodium vivax amine transporter, putative 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis orexin receptor type 2 0.003 0.0351 0.0351
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis serotonin receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptide receptor 0.003 0.0351 0.0351
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0351 0.0351
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.003 0.0351 0.0351
Echinococcus multilocularis sex peptide receptor 0.003 0.0351 0.0351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0351 0.0351
Brugia malayi larval opioid receptor 0.003 0.0351 0.0351
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0351 0.0351
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) RNA binding protein 0.007 0.3573 0.3573
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0351 0.0351
Echinococcus multilocularis g protein coupled receptor 0.003 0.0351 0.0351
Echinococcus granulosus g protein coupled receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide receptor 0.003 0.0351 0.0351
Brugia malayi Serotonin receptor 0.003 0.0351 0.0351
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0 0.5
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Brugia malayi RNA binding protein 0.007 0.3573 0.3573
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi AKH receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis serotonin transporter 0.0149 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide receptor 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis g protein coupled receptor 0.003 0.0351 0.0351
Brugia malayi Dopamine receptor protein 2 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0351 0.0351
Toxoplasma gondii hypothetical protein 0.0025 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0351 0.0351
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0351 0.0351
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0149 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0351 0.0351
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni opsin-like receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide receptor 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus serotonin receptor 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus allatostatin A receptor 0.003 0.0351 0.0351
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.003 0.0351 0.0351
Brugia malayi Serotonin receptor 0.003 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0351 0.0351
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.003 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.003 0.0351 0.0351
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) serotonin transporter b 0.0149 1 1
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.007 0.3573 0.3573
Brugia malayi neuropeptide F receptor 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Brugia malayi G-protein coupled receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Treponema pallidum sodium- and chloride- dependent transporter 0.0149 1 0.5
Echinococcus granulosus g protein coupled receptor 0.003 0.0351 0.0351
Schistosoma mansoni opsin-like receptor 0.003 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.007 0.3573 0.3573
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni myosin xvIII 0.003 0.0351 0.0351
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) solute carrier family 6 member 4 0.0149 1 1
Schistosoma mansoni biogenic amine receptor 0.003 0.0351 0.0351
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0351 0.0351
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0351 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0025 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0351 0.0351
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0351 0.0351
Brugia malayi putative neuropeptide receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0351 0.0351
Echinococcus multilocularis fmrfamide receptor 0.003 0.0351 0.0351
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0351 0.0351
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0351 0.0351
Echinococcus granulosus g-protein coupled receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0351 0.0351
Echinococcus multilocularis allatostatin A receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0351 0.0351
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0351 0.0351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0351 0.0351
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine receptor 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni biogenic amine receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.003 0.0351 0.0351
Schistosoma mansoni amine GPCR 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0351 0.0351
Brugia malayi TAR-binding protein 0.007 0.3573 0.3573
Echinococcus granulosus neuropeptide receptor 0.003 0.0351 0.0351
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0351 0.0351
Loa Loa (eye worm) norepinephrine transporter 0.0149 1 1
Echinococcus granulosus g protein coupled receptor 0.003 0.0351 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0351 0.0351
Brugia malayi G protein-coupled receptor 0.003 0.0351 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0351 0.0351
Echinococcus granulosus somatostatin receptor 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Brugia malayi hypothetical protein 0.003 0.0351 0.0351
Plasmodium falciparum amino acid transporter, putative 0.0025 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0351 0.0351
Toxoplasma gondii hypothetical protein 0.0025 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0351 0.0351
Brugia malayi sulfakinin receptor protein 0.003 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.007 0.3573 0.3573
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0351 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0351 0.0351
Onchocerca volvulus 0.003 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0351
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0351 0.0351

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.1 ug ml-1 Antibacterial activity against Escherichia coli strain 25922 ChEMBL. 15341485
MIC (functional) = 0.1 ug ml-1 Antibacterial activity against Escherichia coli strain 25922 ChEMBL. 15341485
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Staphylococcus aureus strain St au 29213 ChEMBL. 15341485
MIC (functional) = 0.4 ug ml-1 Antibacterial activity against Staphylococcus aureus strain St au 33591 MRSA ChEMBL. 15341485
MIC (functional) = 3.13 ug ml-1 Antibacterial activity against Enterococcus faecalis strain 29212 ChEMBL. 15341485
MIC (functional) = 3.13 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa strain 27853 ChEMBL. 15341485

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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