Detailed information for compound 326646

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.75 | Formula: C13H16ClN5O5
  • H donors: 3 H acceptors: 6 LogP: -1.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCOC(=O)C[C@@H]1O[C@@H]([C@H]([C@@H]1O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C13H16ClN5O5/c14-1-2-23-7(20)3-6-9(21)10(22)13(24-6)19-5-18-8-11(15)16-4-17-12(8)19/h4-6,9-10,13,21-22H,1-3H2,(H2,15,16,17)/t6-,9+,10?,13-/m1/s1
  • InChiKey: HWEXWKZCBYXYAD-YIOFURFMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0777 0.0777
Loa Loa (eye worm) helicase 0.0023 0.0192 0.0222
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0049 0.1406 0.1406
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0775 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.2829 0.2829
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0034 0.0684 0.0981
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0777 0.0895
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0777 0.1114
Echinococcus granulosus GPCR family 2 0.0034 0.0684 0.0981
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0192 0.0276
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0192 0.0222
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0478 0.0685
Loa Loa (eye worm) hypothetical protein 0.0106 0.4095 0.472
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0192 0.0299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0192
Echinococcus multilocularis chromobox protein 1 0.0142 0.5749 0.8245
Schistosoma mansoni chromobox protein 0.0023 0.0192 0.0276
Leishmania major hypothetical protein, conserved 0.0036 0.0777 0.1207
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0777 0.1207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.3112 0.2977
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0192 0.0276
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0084 0.3054 0.4379
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0036 0.0775 0.1205
Plasmodium vivax SET domain protein, putative 0.0029 0.0478 0.0742
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0777 0.0794
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0156 0.6436 1
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0192 0.0222
Schistosoma mansoni chromobox protein 0.0142 0.5749 0.8245
Echinococcus multilocularis Chromo domain 0.0023 0.0192 0.0276
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0192 0.0222
Schistosoma mansoni lamin 0.0028 0.0439 0.0629
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0775 0.1112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0684 0.0981
Loa Loa (eye worm) hypothetical protein 0.0079 0.2829 0.3261
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0156 0.6436 1
Schistosoma mansoni hypothetical protein 0.0168 0.6973 1
Leishmania major S-adenosylhomocysteine hydrolase 0.0156 0.6436 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.3642 0.5222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0478 0.0742
Onchocerca volvulus 0.0052 0.1565 0.14
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0478 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Mycobacterium tuberculosis Conserved protein 0.0036 0.0777 0.0794
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.008 0.2881 0.4132
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0156 0.6436 1
Echinococcus multilocularis lamin 0.0028 0.0439 0.0629
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.4095 0.472
Echinococcus multilocularis adenosylhomocysteinase 0.0156 0.6436 0.923
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.3642 0.5222
Entamoeba histolytica hypothetical protein 0.0023 0.0192 0.0299
Schistosoma mansoni hypothetical protein 0.0023 0.0192 0.0276
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.3642 0.5222
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.1742 0.1742
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0777 0.0777
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1233 0.1768
Schistosoma mansoni hypothetical protein 0.0034 0.0684 0.0981
Brugia malayi CHD4 protein 0.0023 0.0192 0.0222
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0192 0.0299
Trichomonas vaginalis hypothetical protein 0.0023 0.0192 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0478 0.0685
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0478 0.0685
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0777 0.1207
Echinococcus granulosus geminin 0.0168 0.6973 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0777 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0777 0.0777
Trichomonas vaginalis esterase, putative 0.0036 0.0777 0.0777
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0299
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0684 0.0788
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0192 0.0192
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0777 0.0794
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0777 0.1207
Brugia malayi chromobox protein homolog 3 0.0079 0.2829 0.3261
Echinococcus multilocularis lamin dm0 0.0028 0.0439 0.0629
Echinococcus multilocularis potassium voltage gated channel protein 0.0084 0.3054 0.4379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1233 0.1768
Schistosoma mansoni hypothetical protein 0.0036 0.0775 0.1112
Schistosoma mansoni chromobox protein 0.0023 0.0192 0.0276
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0777 0.1207
Entamoeba histolytica hypothetical protein 0.0023 0.0192 0.0299
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.2829 0.2689
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.9786 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1233 0.1768
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0156 0.6436 0.6436
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0192 0.0299
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0192 0.0276
Echinococcus multilocularis GPCR, family 2 0.0034 0.0684 0.0981
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0192
Trichomonas vaginalis chromobox protein, putative 0.0085 0.3112 0.3112
Onchocerca volvulus 0.0062 0.2025 0.1868
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0192 0.0276
Loa Loa (eye worm) hypothetical protein 0.0029 0.0478 0.0551
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0192
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0156 0.6436 0.6577
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0192 0.0299
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.1565 0.2245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.4095 0.472
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0156 0.6436 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0192 0.0299
Brugia malayi beta-lactamase 0.0036 0.0777 0.0895
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0777 0.0777
Echinococcus granulosus adenosylhomocysteinase 0.0156 0.6436 0.923
Brugia malayi beta-lactamase family protein 0.0036 0.0777 0.0895
Trichomonas vaginalis chromobox protein, putative 0.0142 0.5749 0.5749
Schistosoma mansoni lamin 0.0028 0.0439 0.0629
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0777 0.1114
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0156 0.6436 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0192 0.0299
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1233 0.1768
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.2516 0.29
Brugia malayi beta-lactamase family protein 0.0036 0.0777 0.0895
Echinococcus multilocularis musashi 0.0028 0.0439 0.0629
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0192 0.0299
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0192 0.0276
Brugia malayi Protein cec-1. 0.0023 0.0192 0.0222
Entamoeba histolytica adenosylhomocysteinase, putative 0.0156 0.6436 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0777 0.0794
Echinococcus granulosus chromobox protein 1 0.0142 0.5749 0.8245
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0777 0.0794
Loa Loa (eye worm) beta-lactamase 0.0036 0.0777 0.0895
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.6436 0.923
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Trichomonas vaginalis set domain proteins, putative 0.0232 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Brugia malayi hypothetical protein 0.0036 0.0775 0.0894
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0684 0.0788
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0777 0.1114
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0777 0.0777
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0192 0.0276
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.3054 0.4379
Echinococcus granulosus Chromobox protein 3 0.0023 0.0192 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1233 0.1768
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0192 0.0299
Echinococcus multilocularis geminin 0.0168 0.6973 1
Schistosoma mansoni hypothetical protein 0.0034 0.0684 0.0981
Echinococcus multilocularis chromobox protein 2 0.0023 0.0192 0.0276
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0192 0.0276
Toxoplasma gondii adenosylhomocysteinase, putative 0.0156 0.6436 1
Brugia malayi Heterochromatin protein 1 0.0142 0.5749 0.6626
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0156 0.6436 0.6436
Brugia malayi intermediate filament protein 0.0028 0.0439 0.0506
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0192 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1233 0.1768
Brugia malayi Adenosylhomocysteinase 0.0156 0.6436 0.7417
Echinococcus granulosus Chromo domain 0.0023 0.0192 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0478 0.0685
Loa Loa (eye worm) hypothetical protein 0.0034 0.0684 0.0788
Loa Loa (eye worm) hypothetical protein 0.0028 0.0414 0.0478
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0777 0.1114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Onchocerca volvulus 0.0036 0.0777 0.0596
Toxoplasma gondii ABC1 family protein 0.0036 0.0777 0.1207
Mycobacterium tuberculosis Conserved protein 0.0036 0.0777 0.0794
Trichomonas vaginalis chromobox protein, putative 0.0142 0.5749 0.5749
Loa Loa (eye worm) hypothetical protein 0.0073 0.2516 0.29
Entamoeba histolytica hypothetical protein 0.0036 0.0775 0.1205
Mycobacterium ulcerans lipase LipD 0.0036 0.0777 0.1207
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0777 0.0794
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1233 0.1421
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Echinococcus granulosus chromobox protein 2 0.0023 0.0192 0.0276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Echinococcus multilocularis chromobox protein 1 0.0142 0.5749 0.8245
Schistosoma mansoni chromobox protein 0.0142 0.5749 0.8245
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0777 0.1207
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.8677 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0777 0.0794
Onchocerca volvulus 0.0028 0.0439 0.0251
Echinococcus granulosus intermediate filament protein 0.0028 0.0439 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.1742 0.1742
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0439 0.0506
Entamoeba histolytica hypothetical protein 0.0036 0.0775 0.1205
Echinococcus granulosus lamin dm0 0.0028 0.0439 0.0629
Brugia malayi SET domain containing protein 0.0024 0.0243 0.028
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0439 0.0506
Brugia malayi hypothetical protein 0.0023 0.0192 0.0222
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0192 0.0276
Onchocerca volvulus 0.0036 0.0777 0.0596
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0192 0.0192
Brugia malayi Pre-SET motif family protein 0.0204 0.8677 1
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.3642 0.5222
Loa Loa (eye worm) hypothetical protein 0.0062 0.2025 0.2333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Mycobacterium ulcerans hypothetical protein 0.0036 0.0777 0.1207
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0084 0.3054 0.3519
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0777 0.1207
Echinococcus granulosus chromobox protein 1 0.0142 0.5749 0.8245
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0427 0.0613
Schistosoma mansoni hypothetical protein 0.0073 0.2516 0.3609
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Echinococcus granulosus lamin 0.0028 0.0439 0.0629
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1233 0.1421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0684 0.0981
Onchocerca volvulus 0.0028 0.0439 0.0251
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0192 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0777 0.0895
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0777 0.0794
Brugia malayi Pre-SET motif family protein 0.0029 0.0478 0.0551
Loa Loa (eye worm) heterochromatin protein 1 0.0142 0.5749 0.6626
Entamoeba histolytica hypothetical protein 0.0023 0.0192 0.0299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0777 0.0895
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.4095 0.472
Schistosoma mansoni hypothetical protein 0.0034 0.0684 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.0439 0.0506
Echinococcus granulosus potassium voltage gated channel protein 0.0084 0.3054 0.4379
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0684 0.0981
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0192 0.0192
Plasmodium falciparum adenosylhomocysteinase 0.0156 0.6436 1
Schistosoma mansoni hypothetical protein 0.0168 0.6973 1
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.3054 0.4379
Entamoeba histolytica hypothetical protein 0.0036 0.0775 0.1205
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0439 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0684 0.0981
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0156 0.6436 1
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0192 0.0299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0775 0.1112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0192 0.0222
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0684 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Mycobacterium tuberculosis Conserved protein 0.0036 0.0777 0.0794
Trichomonas vaginalis chromobox protein, putative 0.0085 0.3112 0.3112
Loa Loa (eye worm) hypothetical protein 0.0084 0.3054 0.3519
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0192 0.0276
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0156 0.6436 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0439 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1233 0.1768
Loa Loa (eye worm) adenosylhomocysteinase 0.0156 0.6436 0.7417
Onchocerca volvulus 0.0023 0.0192 0.000000058639
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.2829 0.2829
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0478 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0192 0.0192
Onchocerca volvulus 0.0036 0.0777 0.0596

Activities

Activity type Activity value Assay description Source Reference
K inact (binding) = 0.43 1/min Inactivation of human placental AdoHcy hydrolase ChEMBL. 15501043
Ki (binding) = 3.2 uM Inhibition of human placental AdoHcy hydrolase ChEMBL. 15501043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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