TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.488 | Formula: C21H29N5O
H donors: 1 H acceptors: 3 LogP: 3.43 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cnnc(c1)N1CCN([C@@H](C1)C)C(=O)Nc1ccc(cc1)C(C)(C)C
InChi: 1S/C21H29N5O/c1-15-12-19(24-22-13-15)25-10-11-26(16(2)14-25)20(27)23-18-8-6-17(7-9-18)21(3,4)5/h6-9,12-13,16H,10-11,14H2,1-5H3,(H,23,27)/t16-/m1/s1
InChiKey: CKONHGWQVWTZEX-MRXNPFEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Src substrate cortactin	0.0039	0.0122	0.0091
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0051	0.02	0.0284
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0378	0.0456
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0089	0.045	0.0637
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Brugia malayi	Variant SH3 domain containing protein	0.004	0.0129	0.01
Entamoeba histolytica	protein kinase, putative	0.004	0.0129	0.0033
Brugia malayi	hypothetical protein	0.0511	0.318	0.4453
Echinococcus multilocularis	Protein lozenge	0.0064	0.0288	0.0407
Schistosoma mansoni	sorting nexin	0.0039	0.0122	0.0173
Echinococcus multilocularis	Spectrin alpha actinin	0.0039	0.0122	0.0173
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.004	0.0129	0.0182
Loa Loa (eye worm)	SH2 domain-containing protein	0.004	0.0129	0.0182
Echinococcus multilocularis	SH2 domain containing protein 7	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0089	0.045	0.0637
Loa Loa (eye worm)	dihydrofolate reductase	0.0454	0.2806	0.3971
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0039	0.0122	0.0173
Echinococcus granulosus	src region	0.0039	0.0122	0.0173
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Giardia lamblia	Fructose-bisphosphate aldolase	0.0337	0.2055	0.5
Brugia malayi	protein-tyrosine kinase	0.0051	0.02	0.0202
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0051	0.02	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus multilocularis	SHC transforming protein 3	0.004	0.0129	0.0182
Echinococcus granulosus	tensin	0.004	0.0129	0.0182
Brugia malayi	Tensin	0.004	0.0129	0.01
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0078	0.0378	0.0535
Schistosoma mansoni	tensin	0.004	0.0129	0.0182
Treponema pallidum	fructose-bisphosphate aldolase	0.0337	0.2055	0.5
Brugia malayi	Spectrin alpha chain	0.0039	0.0122	0.0091
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0511	0.318	0.4499
Schistosoma mansoni	C-fyn	0.0039	0.0122	0.0173
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.004	0.0129	0.0182
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Schistosoma mansoni	eps8-related protein	0.0039	0.0122	0.0173
Onchocerca volvulus		0.004	0.0129	0.0009
Brugia malayi	Protein kinase domain containing protein	0.0051	0.02	0.0202
Schistosoma mansoni	dynamin-associated protein	0.0039	0.0122	0.0173
Schistosoma mansoni	tensin-related	0.004	0.0129	0.0182
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1566	1	0.5
Echinococcus granulosus	Spectrin alpha actinin	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Schistosoma mansoni	shc transforming protein	0.004	0.0129	0.0182
Onchocerca volvulus		0.0051	0.02	0.0113
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0027	0.0038
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0089	0.045	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus granulosus	SH2 domain containing protein 7	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Schistosoma mansoni	tyrosine kinase	0.0051	0.02	0.0284
Brugia malayi	Peripheral plasma membrane protein CASK	0.0039	0.0122	0.0091
Brugia malayi	cytokine inducible SH2-containing protein 5	0.004	0.0129	0.01
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0089	0.045	0.0637
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0051	0.02	0.0284
Schistosoma mansoni	tyrosine kinase	0.0089	0.045	0.0637
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus multilocularis	intersectin 2	0.0039	0.0122	0.0173
Schistosoma mansoni	SH2A	0.004	0.0129	0.0182
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.004	0.0129	0.0182
Schistosoma mansoni	GTPase activating protein	0.004	0.0129	0.0182
Schistosoma mansoni	dreadlocks/dock	0.0039	0.0122	0.0173
Schistosoma mansoni	zinc finger protein	0.0023	0.0019	0.0027
Echinococcus granulosus	expressed conserved protein	0.004	0.0129	0.0182
Onchocerca volvulus		0.0051	0.02	0.0113
Schistosoma mansoni	vav2	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0051	0.02	0.0284
Brugia malayi	Tyrosine-protein kinase abl-1	0.0089	0.045	0.0558
Echinococcus multilocularis	thymidylate synthase	0.1112	0.7067	1
Echinococcus granulosus	zinc finger protein	0.0023	0.0019	0.0027
Brugia malayi	MH2 domain containing protein	0.0138	0.0764	0.1006
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0089	0.045	0.0637
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Schistosoma mansoni	growth factor receptor-bound protein	0.0078	0.0378	0.0535
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Loa Loa (eye worm)	p53BP2	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Schistosoma mansoni	Dab2-interacting protein-like	0.0039	0.0122	0.0173
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0039	0.0122	0.0173
Onchocerca volvulus		0.004	0.0129	0.0009
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0039	0.0122	0.0173
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0051	0.02	0.0284
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0041	0.0058
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0529	0.3295	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0089	0.045	0.0637
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0089	0.045	0.0637
Echinococcus granulosus	SH2 motif	0.004	0.0129	0.0182
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1112	0.7067	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0078	0.0378	0.0535
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.004	0.0129	0.0182
Echinococcus multilocularis	transfer RNA-Ala	0.0039	0.0122	0.0173
Echinococcus granulosus	dihydrofolate reductase	0.0454	0.2806	0.3971
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	SRC-1	0.0089	0.045	0.0637
Echinococcus granulosus	SH2 domain containing adapter protein F	0.004	0.0129	0.0182
Schistosoma mansoni	run and tbc1 domain containing	0.0039	0.0122	0.0173
Schistosoma mansoni	hypothetical protein	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0089	0.045	0.0637
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0039	0.0122	0.0173
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Loa Loa (eye worm)	SH2 domain-containing protein	0.004	0.0129	0.0182
Brugia malayi	Bromodomain containing protein	0.0087	0.0433	0.0534
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0039	0.0122	0.0173
Echinococcus granulosus	suppressor of cytokine signaling 6	0.004	0.0129	0.0182
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Mycobacterium tuberculosis	Hypothetical protein	0.0529	0.3295	0.3845
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0039	0.0122	0.0173
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0337	0.2055	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.02	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0378	0.0535
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0129	0.0182
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0051	0.02	0.0284
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0005	0.0006
Brugia malayi	SH2 domain containing protein	0.0051	0.02	0.0202
Schistosoma mansoni	suppressor of cytokine signaling	0.004	0.0129	0.0182
Brugia malayi	thymidylate synthase	0.1112	0.7067	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0141	0.0199
Schistosoma mansoni	tensin-related	0.004	0.0129	0.0182
Echinococcus granulosus	expressed protein	0.0039	0.0122	0.0173
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0039	0.0122	0.0173
Echinococcus granulosus	signal transduction protein lnk realted	0.004	0.0129	0.0182
Brugia malayi	hypothetical protein	0.004	0.0129	0.01
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Schistosoma mansoni	tyrosine kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0531	0.0751
Onchocerca volvulus		0.0051	0.02	0.0113
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Onchocerca volvulus		0.1112	0.7067	1
Echinococcus multilocularis	c src tyrosine kinase	0.0089	0.045	0.0637
Echinococcus granulosus	nostrin	0.0039	0.0122	0.0173
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0089	0.045	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0177	0.025
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0454	0.2806	0.3047
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0078	0.0378	0.0535
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0039	0.0122	0.0173
Loa Loa (eye worm)	TK/ABL protein kinase	0.0051	0.02	0.0284
Echinococcus granulosus	SHC transforming protein 3	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0089	0.045	0.0637
Schistosoma mansoni	bromodomain containing protein	0.0073	0.0345	0.0488
Schistosoma mansoni	suppressor of cytokine signaling	0.004	0.0129	0.0182
Echinococcus granulosus	intersectin 2	0.0039	0.0122	0.0173
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.004	0.0129	0.0182
Echinococcus granulosus	SH2 motif	0.004	0.0129	0.0182
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0318	0.0451
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.004	0.0129	0.0182
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0039	0.0122	0.0173
Echinococcus multilocularis	SH2 motif	0.004	0.0129	0.0182
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0318	0.0451
Entamoeba histolytica	SH2 domain containing protein	0.004	0.0129	0.0033
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	0.0764	0.1081
Brugia malayi	SH3 domain containing protein	0.0039	0.0122	0.0091
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0191	0.027
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0039	0.0122	0.0173
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1112	0.7067	1
Echinococcus multilocularis		0.004	0.0129	0.0182
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0089	0.045	0.0637
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0454	0.2806	0.3047
Brugia malayi	dihydrofolate reductase family protein	0.0454	0.2806	0.392
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.004	0.0129	0.0182
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Brugia malayi	tRNA modification GTPase TrmE family protein	0.004	0.0129	0.01
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0089	0.045	0.0637
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0039	0.0122	0.0173
Schistosoma mansoni	tensin	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0511	0.318	0.4499
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Echinococcus granulosus	NCK adaptor protein	0.0078	0.0378	0.0535
Echinococcus granulosus	tyrosine kinase	0.0051	0.02	0.0284
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1566	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0078	0.0378	0.0535
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Schistosoma mansoni	hypothetical protein	0.004	0.0129	0.0182
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.004	0.0129	0.01
Brugia malayi	SH2 domain containing protein	0.0051	0.02	0.0202
Echinococcus multilocularis	SH2 motif	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.004	0.0129	0.0182
Echinococcus multilocularis	signal transduction protein lnk realted	0.004	0.0129	0.0182
Brugia malayi	Protein kinase domain containing protein	0.0051	0.02	0.0202
Brugia malayi	Dihydrofolate reductase	0.0454	0.2806	0.392
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1112	0.7067	1
Echinococcus multilocularis	N chimaerin	0.004	0.0129	0.0182
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0041	0.0058
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0089	0.045	0.0637
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0378	0.0456
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Loa Loa (eye worm)	thymidylate synthase	0.1112	0.7067	1
Brugia malayi	hypothetical protein	0.0529	0.3295	0.4618
Schistosoma mansoni	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus multilocularis	tyrosine kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	thyroid receptor interactor	0.0039	0.0122	0.0173
Schistosoma mansoni	tyrosine kinase	0.0089	0.045	0.0637
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Schistosoma mansoni	adapter molecule crk	0.0078	0.0378	0.0535
Onchocerca volvulus		0.0051	0.02	0.0113
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1566	1	1
Onchocerca volvulus		0.004	0.0129	0.0009
Echinococcus multilocularis	NCK adaptor protein	0.0078	0.0378	0.0535
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.004	0.0129	0.0033
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.004	0.0129	0.0182
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0159	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Echinococcus granulosus	N chimaerin	0.004	0.0129	0.0182
Echinococcus granulosus	endophilin A3	0.0039	0.0122	0.0173
Echinococcus multilocularis	tensin	0.004	0.0129	0.0182
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0078	0.0378	0.0535
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0141	0.0199
Chlamydia trachomatis	dihydrofolate reductase	0.0454	0.2806	0.5
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Onchocerca volvulus		0.0051	0.02	0.0113
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1566	1	0.5
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0039	0.0122	0.0173
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	0.0764	0.1081
Echinococcus granulosus	suppressor of cytokine signaling 7	0.004	0.0129	0.0182
Schistosoma mansoni	hypothetical protein	0.0039	0.0122	0.0173
Schistosoma mansoni	nck2/grb4	0.0078	0.0378	0.0535
Brugia malayi	Myosin tail family protein	0.0039	0.0122	0.0091
Schistosoma mansoni	signal transduction protein lnk-related	0.004	0.0129	0.0182
Echinococcus multilocularis	endophilin A3	0.0039	0.0122	0.0173
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0051	0.02	0.0284
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0051	0.02	0.0284
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0529	0.3295	0.3212
Echinococcus multilocularis	zinc finger protein	0.0023	0.0019	0.0027
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Onchocerca volvulus		0.004	0.0129	0.0009
Echinococcus multilocularis	tensin	0.004	0.0129	0.0182
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.004	0.0129	0.0182
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0129	0.0182
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Echinococcus granulosus	thymidylate synthase	0.1112	0.7067	1
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.0122	0.0091
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0122	0.0173
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0194	0.0275
Schistosoma mansoni	sorbin	0.0039	0.0122	0.0173
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0039	0.0122	0.0173
Brugia malayi	STAT protein, DNA binding domain containing protein	0.004	0.0129	0.01
Schistosoma mansoni	tyrosine kinase	0.0089	0.045	0.0637
Echinococcus granulosus	tyrosine kinase	0.0051	0.02	0.0284
Echinococcus granulosus	tyrosine protein kinase Blk	0.0051	0.02	0.0284
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Brugia malayi	hypothetical protein	0.0102	0.0531	0.0673
Schistosoma mansoni	dihydrofolate reductase	0.0454	0.2806	0.3971
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Brugia malayi	SRC-1	0.0089	0.045	0.0558
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.004	0.0129	0.0182
Echinococcus multilocularis	dihydrofolate reductase	0.0454	0.2806	0.3971
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.045	0.0637
Brugia malayi	Protein kinase domain containing protein	0.0051	0.02	0.0202
Schistosoma mansoni	lozenge	0.0064	0.0288	0.0407
Onchocerca volvulus		0.0511	0.318	0.4403
Brugia malayi	hypothetical protein	0.0051	0.02	0.0202
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Brugia malayi	Variant SH3 domain containing protein	0.004	0.0129	0.01
Onchocerca volvulus		0.0051	0.02	0.0113
Brugia malayi	RhoGAP domain containing protein	0.004	0.0129	0.01
Echinococcus multilocularis	tyrosine protein kinase shark	0.0051	0.02	0.0284
Schistosoma mansoni	cell polarity protein	0.0039	0.0122	0.0173
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0051	0.02	0.0405
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0051	0.02	0.0284
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.004	0.0129	0.0182
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.004	0.0129	0.0009
Brugia malayi	Sex muscle abnormal protein 5	0.0078	0.0378	0.0456
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0337	0.2055	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.004	0.0129	0.0182
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.004	0.0129	0.0182
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.004	0.0129	0.0182
Echinococcus multilocularis	SH2 motif	0.004	0.0129	0.0182
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0041	0.0058
Echinococcus granulosus	growth factor receptor bound protein 2	0.0078	0.0378	0.0535
Echinococcus granulosus	tyrosine protein kinase Srms	0.0051	0.02	0.0284
Onchocerca volvulus		0.004	0.0129	0.0009
Echinococcus multilocularis	nostrin	0.0039	0.0122	0.0173
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0039	0.0122	0.0091
Brugia malayi	protein-tyrosine kinase	0.0039	0.0122	0.0091
Loa Loa (eye worm)	STAT protein	0.004	0.0129	0.0182
Schistosoma mansoni	hypothetical protein	0.0024	0.0027	0.0038
Echinococcus granulosus	hypothetical protein	0.004	0.0129	0.0182
Loa Loa (eye worm)	TK protein kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	runx1	0.0064	0.0288	0.0407
Echinococcus multilocularis	expressed protein	0.0039	0.0122	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0531	0.0751
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0401	0.0567
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Schistosoma mansoni	formin binding protein and related proteins	0.0039	0.0122	0.0173
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0089	0.045	0.0637
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0454	0.2806	0.3047
Schistosoma mansoni	tyrosine kinase	0.0089	0.045	0.0637
Loa Loa (eye worm)	protein-tyrosine kinase	0.0039	0.0122	0.0173
Brugia malayi	Protein kinase domain containing protein	0.0051	0.02	0.0202
Loa Loa (eye worm)	guanylate kinase	0.0039	0.0122	0.0173
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.004	0.0129	0.0009
Echinococcus granulosus	tyrosine protein kinase shark	0.0051	0.02	0.0284
Mycobacterium ulcerans	thymidylate synthase	0.1112	0.7067	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Schistosoma mansoni	tensin	0.004	0.0129	0.0182
Brugia malayi	Guanylate kinase family protein	0.0039	0.0122	0.0091
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0089	0.045	0.0637
Onchocerca volvulus		0.004	0.0129	0.0009
Schistosoma mansoni	eyes absent homolog	0.0102	0.0531	0.0751
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.004	0.0129	0.0182
Brugia malayi	SH2 domain containing protein	0.004	0.0129	0.01
Brugia malayi	Bromodomain containing protein	0.0044	0.0159	0.0143
Loa Loa (eye worm)	SH2 domain-containing protein	0.004	0.0129	0.0182
Loa Loa (eye worm)	hypothetical protein	0.004	0.0129	0.0182
Echinococcus granulosus	c src tyrosine kinase	0.0089	0.045	0.0637
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1566	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0051	0.02	0.0284
Schistosoma mansoni	apoptosis stimulating of P53	0.0039	0.0122	0.0173
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0337	0.2055	0.6091
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0039	0.0122	0.0173

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8590.7 nM	Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay	ChEMBL.	15482915
IC50 (binding)	= 8590.7 nM	Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay	ChEMBL.	15482915
IC50 (binding)	> 25000 nM	Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay	ChEMBL.	15482915
IC50 (binding)	> 25000 nM	Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay	ChEMBL.	15482915

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL433587

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 326749