TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 525.938 | Formula: C21H21ClFN5O6S
H donors: 2 H acceptors: 6 LogP: 2.46 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2c(N)nc(nc2cc1OC)N1CCN(CC1)S(=O)(=O)c1cc(F)c(c(c1)C(=O)O)Cl
InChi: 1S/C21H21ClFN5O6S/c1-33-16-9-12-15(10-17(16)34-2)25-21(26-19(12)24)27-3-5-28(6-4-27)35(31,32)11-7-13(20(29)30)18(22)14(23)8-11/h7-10H,3-6H2,1-2H3,(H,29,30)(H2,24,25,26)
InChiKey: SOXMWWKHRJDYKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase shark	0.0048	0.0076	0.0108
Schistosoma mansoni	tensin	0.0035	0.0005	0.0007
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0035	0.0005	0.0007
Echinococcus granulosus	SH2 motif	0.0035	0.0005	0.0007
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.007	0.0205	0.0291
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0082	0.0276	0.0392
Onchocerca volvulus		0.0035	0.0005	0.0007
Echinococcus granulosus	N chimaerin	0.0035	0.0005	0.0007
Echinococcus multilocularis	thymidylate synthase	0.1254	0.7045	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.0005	0.0007
Schistosoma mansoni	dihydrofolate reductase	0.0511	0.2754	0.3909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0048	0.0076	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1132	0.6342	0.6342
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0048	0.0076	0.0108
Entamoeba histolytica	protein kinase, putative	0.004	0.003	0.3971
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0005	0.0007
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0035	0.0005	0.0007
Brugia malayi	Tyrosine-protein kinase abl-1	0.0082	0.0276	0.0392
Onchocerca volvulus		0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Brugia malayi	hypothetical protein	0.0048	0.0076	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0001	0.0002
Schistosoma mansoni	protein kinase	0.0504	0.2713	0.385
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.007	0.0205	0.0291
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Brugia malayi	Variant SH3 domain containing protein	0.007	0.0205	0.0291
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0082	0.0276	0.0392
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0082	0.0276	0.0392
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0076	0.0108
Brugia malayi	protein-tyrosine kinase	0.0048	0.0076	0.0108
Schistosoma mansoni	tyrosine kinase	0.0048	0.0076	0.0108
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0048	0.0076	0.0108
Echinococcus granulosus	tensin	0.0035	0.0005	0.0007
Echinococcus granulosus	NCK adaptor protein	0.007	0.0205	0.0291
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1254	0.7045	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0082	0.0276	0.0392
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0035	0.0005	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0005	0.0007
Schistosoma mansoni	adapter molecule crk	0.007	0.0205	0.0291
Echinococcus multilocularis	tyrosine kinase	0.0048	0.0076	0.0108
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0087	0.0302	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Onchocerca volvulus		0.0035	0.0005	0.0007
Loa Loa (eye worm)	SRC-1	0.0082	0.0276	0.0392
Echinococcus multilocularis	N chimaerin	0.0035	0.0005	0.0007
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0596	0.3247	0.3247
Loa Loa (eye worm)	dihydrofolate reductase	0.0511	0.2754	0.3909
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0076	0.0108
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0035	0.0005	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0076	0.0108
Echinococcus multilocularis	tensin	0.0035	0.0005	0.0007
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0035	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	protein kinase	0.0504	0.2713	0.385
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1254	0.7045	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1765	1	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0596	0.3247	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.007	0.0205	0.0291
Echinococcus granulosus	dihydrofolate reductase	0.0511	0.2754	0.3909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Brugia malayi	Guanylate kinase family protein	0.0041	0.0037	0.0052
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Onchocerca volvulus		0.0048	0.0076	0.0108
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0076	0.0108
Schistosoma mansoni	tyrosine kinase	0.0048	0.0076	0.0108
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0048	0.0076	0.0108
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0076	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0035	0.0005	0.0007
Echinococcus granulosus	SH2 domain containing protein 7	0.0035	0.0005	0.0007
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0082	0.0276	0.0392
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0048	0.0076	0.0108
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0035	0.0005	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0076	0.0108
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine kinase	0.0048	0.0076	0.0108
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.0005	0.0007
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0035	0.0001	0.0002
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0035	0.0005	0.0007
Schistosoma mansoni	tensin-related	0.0035	0.0005	0.0007
Loa Loa (eye worm)	SH2 domain-containing protein	0.0035	0.0005	0.0007
Schistosoma mansoni	tensin	0.0035	0.0005	0.0007
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0035	0.0005	0.0007
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0005	0.0007
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0035	0.0005	0.0007
Brugia malayi	Tensin	0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0048	0.0076	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Chlamydia trachomatis	dihydrofolate reductase	0.0511	0.2754	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.007	0.0205	0.0291
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.004	0.003	0.3971
Brugia malayi	Sex muscle abnormal protein 5	0.007	0.0205	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1254	0.7045	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0048	0.0076	0.0108
Brugia malayi	hypothetical protein	0.0596	0.3247	0.4608
Brugia malayi	RhoGAP domain containing protein	0.0035	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.007	0.0205	0.0291
Echinococcus multilocularis	SH2 motif	0.0035	0.0005	0.0007
Schistosoma mansoni	signal transduction protein lnk-related	0.0035	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	suppressor of cytokine signaling	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0048	0.0076	0.0108
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0035	0.0005	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0076	0.0108
Echinococcus multilocularis	c src tyrosine kinase	0.0082	0.0276	0.0392
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Brugia malayi	SH2 domain containing protein	0.0048	0.0076	0.0108
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1132	0.6342	0.9001
Echinococcus granulosus	thymidylate synthase	0.1254	0.7045	1
Onchocerca volvulus		0.0035	0.0005	0.0007
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.1132	0.6342	0.6342
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1132	0.6342	0.9001
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1765	1	0.5
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Echinococcus multilocularis	SHC transforming protein 3	0.0035	0.0005	0.0007
Onchocerca volvulus		0.0048	0.0076	0.0108
Onchocerca volvulus		0.0048	0.0076	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0504	0.2713	0.385
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.1132	0.6342	0.6342
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Schistosoma mansoni	nck2/grb4	0.007	0.0205	0.0291
Onchocerca volvulus		0.0048	0.0076	0.0108
Echinococcus multilocularis	NCK adaptor protein	0.007	0.0205	0.0291
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Schistosoma mansoni	growth factor receptor-bound protein	0.007	0.0205	0.0291
Echinococcus granulosus	mitogen activated protein kinase 14	0.1132	0.6342	0.9001
Onchocerca volvulus		0.0045	0.0062	0.0088
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0035	0.0005	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1132	0.6342	0.9001
Echinococcus granulosus	signal transduction protein lnk realted	0.0035	0.0005	0.0007
Brugia malayi	P38 map kinase family protein 2	0.1132	0.6342	0.9001
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0005	0.0007
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0035	0.0005	0.0007
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0035	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	SH2A	0.0035	0.0005	0.0007
Schistosoma mansoni	tyrosine kinase	0.0082	0.0276	0.0392
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.007	0.0205	0.0291
Echinococcus multilocularis	tensin	0.0035	0.0005	0.0007
Loa Loa (eye worm)	thymidylate synthase	0.1254	0.7045	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1132	0.6342	0.6342
Echinococcus multilocularis	SH2 motif	0.0035	0.0005	0.0007
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0504	0.2713	0.385
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.0005	0.0007
Mycobacterium ulcerans	thymidylate synthase	0.1254	0.7045	1
Echinococcus granulosus	c src tyrosine kinase	0.0082	0.0276	0.0392
Echinococcus granulosus	tyrosine kinase	0.0048	0.0076	0.0108
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0035	0.0005	0.0007
Schistosoma mansoni	tensin-related	0.0035	0.0005	0.0007
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1765	1	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0035	0.0005	0.0007
Onchocerca volvulus		0.0048	0.0076	0.0108
Schistosoma mansoni	GTPase activating protein	0.0035	0.0005	0.0007
Echinococcus multilocularis	SH2 domain containing protein 7	0.0035	0.0005	0.0007
Echinococcus granulosus	growth factor receptor bound protein 2	0.007	0.0205	0.0291
Brugia malayi	SRC-1	0.0082	0.0276	0.0392
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0035	0.0005	0.0007
Schistosoma mansoni	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0071	0.0101
Schistosoma mansoni	tyrosine kinase	0.0082	0.0276	0.0392
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase shark	0.0048	0.0076	0.0108
Schistosoma mansoni	suppressor of cytokine signaling	0.0035	0.0005	0.0007
Onchocerca volvulus		0.1254	0.7045	1
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0035	0.0005	0.0007
Echinococcus multilocularis	dihydrofolate reductase	0.0511	0.2754	0.3909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Echinococcus granulosus	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0082	0.0276	0.0392
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0082	0.0276	0.0392
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0048	0.0076	0.0108
Entamoeba histolytica	SH2 domain containing protein	0.0035	0.0005	0.0668
Brugia malayi	Peripheral plasma membrane protein CASK	0.0041	0.0037	0.0052
Echinococcus granulosus	SH2 motif	0.0035	0.0005	0.0007
Brugia malayi	Dihydrofolate reductase	0.0511	0.2754	0.3909
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0082	0.0276	0.0392
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1765	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0035	0.0005	0.0007
Echinococcus multilocularis		0.0035	0.0005	0.0007
Onchocerca volvulus		0.0035	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine protein kinase Srms	0.0048	0.0076	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Schistosoma mansoni	tyrosine kinase	0.0082	0.0276	0.0392
Onchocerca volvulus		0.0035	0.0005	0.0007
Brugia malayi	SH2 domain containing protein	0.0048	0.0076	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0076	0.0108
Brugia malayi	hypothetical protein	0.0035	0.0005	0.0007
Echinococcus multilocularis	SH2 motif	0.0035	0.0005	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0035	0.0005	0.0007
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0082	0.0276	0.0392
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0082	0.0276	0.0392
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.1132	0.6342	0.9001
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1765	1	1
Brugia malayi	dihydrofolate reductase family protein	0.0511	0.2754	0.3909
Schistosoma mansoni	hypothetical protein	0.0035	0.0005	0.0007
Loa Loa (eye worm)	SH2 domain-containing protein	0.0035	0.0005	0.0007
Echinococcus granulosus	mitogen activated protein kinase 11	0.1132	0.6342	0.9001
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0082	0.0276	0.0392
Schistosoma mansoni	tensin	0.0035	0.0005	0.0007
Onchocerca volvulus		0.0048	0.0076	0.0108
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0035	0.0005	0.0007
Mycobacterium tuberculosis	Hypothetical protein	0.0596	0.3247	0.1148
Loa Loa (eye worm)	STAT protein	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.0005	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Brugia malayi	Variant SH3 domain containing protein	0.007	0.0205	0.0291
Brugia malayi	thymidylate synthase	0.1254	0.7045	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine protein kinase Blk	0.0048	0.0076	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0082	0.0276	0.0392
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1132	0.6342	0.9001
Schistosoma mansoni	vav2	0.0035	0.0005	0.0007
Echinococcus granulosus	SHC transforming protein 3	0.0035	0.0005	0.0007
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Schistosoma mansoni	shc transforming protein	0.0035	0.0005	0.0007
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0082	0.0276	0.0392
Schistosoma mansoni	tyrosine kinase	0.0082	0.0276	0.0392
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0082	0.0276	0.0392
Brugia malayi	SH2 domain containing protein	0.0035	0.0005	0.0007
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0035	0.0005	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0076	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0007
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0082	0.0276	0.0392
Echinococcus granulosus	expressed conserved protein	0.0035	0.0005	0.0007
Loa Loa (eye worm)	guanylate kinase	0.0041	0.0037	0.0052
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0035	0.0005	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 56 uM	Inhibition of prostate cancer (PC-3) cell proliferation	ChEMBL.	15317457
IC50 (functional)	= 56 uM	Inhibition of prostate cancer (PC-3) cell proliferation	ChEMBL.	15317457

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

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Detailed information for compound 326792