Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.0598 | 0.1664 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.0598 | 0.2064 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0022 | 0.0615 | 0.0339 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0022 | 0.0615 | 0.0818 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0025 | 0.0782 | 0.1621 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0022 | 0.0615 | 0.0339 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0022 | 0.0615 | 0.0339 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0022 | 0.0615 | 0.0634 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0026 | 0.0902 | 0.4065 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0286 | 0.0145 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.0902 | 0.2261 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0158 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0039 | 0.1804 | 0.5821 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.258 | 0.3553 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.1015 | 0.2676 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.4307 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0028 | 0.1015 | 0.481 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0076 | 0.4307 | 0.6119 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0782 | 0.1235 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.0598 | 0.1148 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0039 | 0.1804 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0034 | 0.1402 | 0.1149 |
Schistosoma mansoni | glutamate receptor kainate | 0.0022 | 0.0615 | 0.0634 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.258 | 0.2362 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0022 | 0.0615 | 0.1223 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0022 | 0.0615 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0286 | 0.0145 |
Schistosoma mansoni | glutamate receptor kainate | 0.0022 | 0.0615 | 0.0634 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0114 | 0.6919 | 0.6828 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.258 | 0.5705 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0286 | 0.0441 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0057 | 0.3016 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1687 | 0.3485 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.258 | 0.2362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.258 | 0.3553 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0079 | 0.4526 | 0.4365 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.0546 | 0.0957 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0025 | 0.0782 | 0.2299 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.258 | 0.3553 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.0546 | 0.172 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0022 | 0.0615 | 0.0339 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0057 | 0.3016 | 0.5 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0022 | 0.0615 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2142 | 0.4854 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0022 | 0.0615 | 0.0634 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0039 | 0.1804 | 0.5821 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.0902 | 0.2261 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0057 | 0.3016 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0902 | 0.2261 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0022 | 0.057 | 0.1567 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0114 | 0.6919 | 0.6828 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0039 | 0.1804 | 0.5562 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.1363 | 0.3002 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0022 | 0.0615 | 0.0634 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0286 | 0.0441 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0028 | 0.1015 | 0.3103 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0026 | 0.0846 | 0.252 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0022 | 0.0615 | 0.0634 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0026 | 0.0846 | 0.252 |
Schistosoma mansoni | glutamate receptor kainate | 0.0022 | 0.0615 | 0.0634 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0028 | 0.1015 | 0.481 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2894 | 0.6487 |
Chlamydia trachomatis | glutamine binding protein | 0.0057 | 0.3016 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0019 | 0.0376 | 0.0544 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.0388 | 0.0942 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0057 | 0.3016 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.258 | 0.2362 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0057 | 0.3016 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.1015 | 0.3103 |
Echinococcus multilocularis | NMDA receptor | 0.0022 | 0.0615 | 0.0339 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0022 | 0.0615 | 0.0339 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.0902 | 0.2261 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0028 | 0.1015 | 0.1467 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.009 | 0.5313 | 0.5175 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.1363 | 0.2679 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0022 | 0.0615 | 0.0339 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0026 | 0.0902 | 0.1533 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0114 | 0.6919 | 0.6828 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0114 | 0.6919 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0114 | 0.6919 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.0114 | 0.6919 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.0598 | 0.1148 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0022 | 0.0615 | 0.0339 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.0902 | 0.2712 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0286 | 0.0145 |
Brugia malayi | Melibiase family protein | 0.0076 | 0.4307 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0615 | 0.0634 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1687 | 0.2227 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.0878 | 0.1849 |
Toxoplasma gondii | Alpha-galactosidase | 0.0016 | 0.0188 | 0.0272 |
Onchocerca volvulus | 0.0046 | 0.2253 | 0.9285 | |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0022 | 0.0615 | 0.0339 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0079 | 0.4553 | 0.4392 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0028 | 0.1015 | 0.481 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2894 | 0.6642 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.005 | 0.2535 | 0.5593 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2894 | 0.6487 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0076 | 0.4307 | 0.6119 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.0902 | 0.2261 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0034 | 0.1402 | 0.1149 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0022 | 0.0615 | 0.0818 |
Mycobacterium ulcerans | polyketide synthase | 0.0028 | 0.1015 | 0.2676 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1687 | 0.3772 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0026 | 0.0902 | 0.2712 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0028 | 0.1015 | 0.2676 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0113 | 0.685 | 0.9897 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0114 | 0.6919 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0902 | 0.2712 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2894 | 0.6642 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0026 | 0.0902 | 0.4065 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.258 | 0.5895 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0034 | 0.1402 | 0.1149 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0028 | 0.1015 | 0.3103 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0286 | 0.0145 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0076 | 0.4307 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.009 | 0.5313 | 0.5175 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0079 | 0.4526 | 0.4365 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0022 | 0.0615 | 0.1223 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.0261 | 0.0378 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.258 | 0.2362 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.1402 | 0.1149 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0114 | 0.6919 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.0546 | 0.0957 |
Echinococcus granulosus | glutamate receptor 2 | 0.0034 | 0.1402 | 0.1149 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0048 | 0.2366 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.