TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 483.601 | Formula: C30H33N3O3
H donors: 2 H acceptors: 2 LogP: 4.41 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)c1ccc(cc1)/C(=C\1/CC2CCC(C1)N2Cc1ccoc1)/c1ccc(cc1)NC(=O)C
InChi: 1S/C30H33N3O3/c1-3-31-30(35)24-6-4-22(5-7-24)29(23-8-10-26(11-9-23)32-20(2)34)25-16-27-12-13-28(17-25)33(27)18-21-14-15-36-19-21/h4-11,14-15,19,27-28H,3,12-13,16-18H2,1-2H3,(H,31,35)(H,32,34)
InChiKey: LIOYNOOYVXTCGU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	opioid receptor, mu 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0374	0.0994
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0374	0.0391
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0071
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0708	0.0697
Echinococcus multilocularis	dna polymerase kappa	0.002	0.014	0.0129
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0286	0.0564
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0374	0.0994
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0125	0.0113
Schistosoma mansoni	rab6-interacting	0.0019	0.0125	0.0311
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.2575	0.7034
Schistosoma mansoni	hypothetical protein	0.0176	0.3656	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0038	0.0026
Brugia malayi	nuclear receptor RXR	0.0014	0.0012	0.0007
Echinococcus granulosus	GPCR family 2	0.0016	0.0038	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0374	0.0744
Onchocerca volvulus		0.0019	0.0125	0.0121
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.014	0.0129
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0374	0.0994
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0757	0.2045
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0051	0.0039
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0374	0.0363
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0051	0.0045
Brugia malayi	nuclear hormone receptor	0.003	0.0374	0.0744
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Schistosoma mansoni	polycystin 1-related	0.0019	0.0125	0.0311
Onchocerca volvulus	Phospholipase A2 homolog	0.043	0.9373	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Brugia malayi	hypothetical protein	0.0019	0.0125	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0374	0.0391
Onchocerca volvulus	Phospholipase A2 homolog	0.0091	0.1727	0.1832
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.014	0.5
Brugia malayi	hypothetical protein	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0275	0.0285
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.014	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0125	0.0125
Brugia malayi	ecdysteroid receptor	0.003	0.0374	0.0744
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0374	0.0744
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.014	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0374	0.0363
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0374	0.0363
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0708	0.0697
Schistosoma mansoni	hypothetical protein	0.0034	0.0443	0.1184
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0374	0.0994
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.2575	0.7034
Brugia malayi	hypothetical protein	0.0233	0.4928	1
Brugia malayi	nuclear receptor NHR-88	0.0014	0.0012	0.0007
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0374	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.2575	0.7034
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0125	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0.3656	1
Echinococcus granulosus	RUN	0.0019	0.0125	0.0113
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0071
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0125	0.0113
Schistosoma mansoni	lamin	0.0027	0.0286	0.0752
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0374	0.0363
Echinococcus granulosus	intermediate filament protein	0.0027	0.0286	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0045
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0051	0.0086
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0374	0.0744
Brugia malayi	hypothetical protein	0.0016	0.0051	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Echinococcus granulosus	tar DNA binding protein	0.0128	0.2575	0.2567
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.014	0.0352
Echinococcus granulosus	neuropeptide receptor A26	0.0458	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0374	0.0391
Onchocerca volvulus		0.003	0.0374	0.0387
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0374	0.0744
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0793	0.1595
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.014	0.5
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0125	0.5
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.014	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0045
Loa Loa (eye worm)	hypothetical protein	0.043	0.9373	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0374	0.0363
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.014	0.5
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0125	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0374	0.0994
Echinococcus granulosus	dna polymerase eta	0.0047	0.0737	0.0726
Brugia malayi	intermediate filament protein	0.0027	0.0286	0.0564
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0425	0.4775
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0374	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0793	0.0838
Echinococcus multilocularis	RUN	0.0019	0.0125	0.0113
Echinococcus multilocularis	geminin	0.0176	0.3656	0.3649
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0286	0.0752
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0708	0.0747
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.2575	0.2741
Brugia malayi	steroid hormone receptor	0.003	0.0374	0.0744
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0374	0.0744
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.0737	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0757	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Brugia malayi	orphan nuclear receptor NR2E1	0.0014	0.0012	0.0007
Schistosoma mansoni	rab6-interacting	0.0019	0.0125	0.0311
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0286	0.0296
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0374	0.0363
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0038	0.0026
Brugia malayi	hypothetical protein	0.0016	0.0051	0.0086
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0374	0.0387
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0038	0.006
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0045
Giardia lamblia	DINP protein human, muc B family	0.002	0.014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Schistosoma mansoni	DNA polymerase eta	0.0047	0.0737	0.1989
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0374	0.0994
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0374	0.0387
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0374	0.0744
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0374	0.0744
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Echinococcus granulosus	lamin	0.0027	0.0286	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0125	0.0113
Echinococcus multilocularis	musashi	0.0027	0.0286	0.0274
Schistosoma mansoni	coup transcription factor	0.003	0.0374	0.0994
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.2575	0.2741
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0374	0.0391
Brugia malayi	conserved hypotetical protein	0.0014	0.0012	0.0007
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.2575	0.7034
Loa Loa (eye worm)	nuclear hormone receptor	0.0014	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0737	0.0778
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0374	0.0744
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.0737	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0374	0.0994
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0374	0.0744
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.235	0.25
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0374	0.0363
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0374	0.0363
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0012	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0125	0.0237
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0374	0.0363
Brugia malayi	RNA binding protein	0.0128	0.2575	0.5218
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.014	0.1904
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0374	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Loa Loa (eye worm)	DR-78	0.0014	0.0012	0.0004
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0374	0.0363
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.0737	0.148
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0912	0.0901
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0374	0.0994
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0038	0.006
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0374	0.0744
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0374	0.0744
Echinococcus granulosus	geminin	0.0176	0.3656	0.3649
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0708	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0045
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.014	0.0129
Schistosoma mansoni	lipoxygenase	0.0054	0.0912	0.2469
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0708	0.0697
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0374	0.0994
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0374	0.0363
Echinococcus granulosus	dna polymerase kappa	0.002	0.014	0.0129
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0708	0.191
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0374	0.0994
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0051	0.0106
Echinococcus multilocularis	neuropeptide s receptor	0.0458	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0374	0.0744
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0071
Brugia malayi	nuclear hormone receptor	0.0014	0.0012	0.0007
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.2575	0.5218
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0286	0.0296
Brugia malayi	tailless protein	0.0014	0.0012	0.0007
Schistosoma mansoni	hypothetical protein	0.0019	0.0125	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0374	0.0744
Schistosoma mansoni	lipoxygenase	0.0019	0.0125	0.0311
Trypanosoma brucei	unspecified product	0.002	0.014	0.1904
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0374	0.0363
Brugia malayi	Doublecortin family protein	0.0019	0.0125	0.0237
Brugia malayi	nuclear receptor RXR	0.0016	0.0051	0.0086
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0793	0.0838
Brugia malayi	MH2 domain containing protein	0.0118	0.235	0.4759
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0125	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0374	0.0391
Onchocerca volvulus		0.0027	0.0286	0.0293
Leishmania major	DNA polymerase eta, putative	0.0047	0.0737	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0125	0.0125
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0051	0.0086
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.014	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0708	0.0697
Schistosoma mansoni	hypothetical protein	0.0016	0.0038	0.0071
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.014	0.1904
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0051	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Brugia malayi	TAR-binding protein	0.0128	0.2575	0.5218
Echinococcus multilocularis	lamin dm0	0.0027	0.0286	0.0274
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0374	0.0363
Brugia malayi	nuclear receptor NHR-67	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0443	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0125	0.0125
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0374	0.0363
Brugia malayi	Phospholipase A2 family protein	0.0091	0.1727	0.3494
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Loa Loa (eye worm)	RNA binding protein	0.0128	0.2575	0.2741
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0374	0.0994
Onchocerca volvulus		0.0019	0.0125	0.0121
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0125	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0233	0.4928	0.5254
Schistosoma mansoni	lamin	0.0027	0.0286	0.0752
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0374	0.0363
Onchocerca volvulus		0.0047	0.0757	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0038	0.0031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0708	0.191
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0374	0.0391
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.014	0.0352
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0374	0.0391
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0443	0.0884
Brugia malayi	nuclear hormone receptor family member odr-7	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.014	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0374	0.0363
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.235	0.25
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0425	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0374	0.0391
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0014	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0286	0.0296
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0038	0.0026
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0374	0.0994
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.2575	0.2567
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0038	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Brugia malayi	nuclear receptor NHR-88	0.003	0.0374	0.0744
Echinococcus multilocularis	dna polymerase eta	0.0047	0.0737	0.0726
Onchocerca volvulus		0.0027	0.0286	0.0293
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.014	0.0268
Brugia malayi	ecdysone receptor	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0014	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0051	0.0039
Echinococcus granulosus	lamin dm0	0.0027	0.0286	0.0274
Brugia malayi	hypothetical protein	0.0014	0.0012	0.0007
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.4928	0.4922
Schistosoma mansoni	loxhd1	0.0019	0.0125	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0374	0.0744
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0793	0.1595
Echinococcus multilocularis	lamin	0.0027	0.0286	0.0274
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0374	0.0387
Schistosoma mansoni	hypothetical protein	0.0047	0.0757	0.2045
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.2575	0.7034
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0912	0.0901
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.014	0.1904
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0708	0.191
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.014	0.1904
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0038	0.0031
Leishmania major	DNA polymerase eta, putative	0.0033	0.0425	0.4775
Loa Loa (eye worm)	hypothetical protein	0.003	0.0374	0.0391
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.4928	0.4922
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0374	0.0363
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0012	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1727	0.1835
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0038	0.0026

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.34 nM	Binding affinity against delta opioid receptor in mouse hot plate test	ChEMBL.	15482911
Ki (binding)	= 0.8 nM	Binding affinity against mu opioid receptor in mouse hot plate test	ChEMBL.	15482911
Ki (binding)	= 0.8 nM	Binding affinity against mu opioid receptor in mouse hot plate test	ChEMBL.	15482911
Ratio (binding)	= 2.4	Ratio of binding affinity against mu to that of delta opioid receptor	ChEMBL.	15482911
Ratio (binding)	= 2.4	Ratio of binding affinity against mu to that of delta opioid receptor	ChEMBL.	15482911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL427331

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 327078