TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.55 | Formula: C28H22N2O4S
H donors: 2 H acceptors: 4 LogP: 5.6 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1cc2c(n1Cc1ccccc1)ccc(c2)NS(=O)(=O)c1ccc(cc1)c1ccccc1
InChi: 1S/C28H22N2O4S/c31-28(32)27-18-23-17-24(13-16-26(23)30(27)19-20-7-3-1-4-8-20)29-35(33,34)25-14-11-22(12-15-25)21-9-5-2-6-10-21/h1-18,29H,19H2,(H,31,32)
InChiKey: MPTVOCKJLMHNEQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear hormone receptor	0.0106	0.1103	0.3257
Echinococcus granulosus	Nuclear hormone receptor HR96	0.005	0.0414	0.0607
Echinococcus multilocularis	geminin	0.0194	0.217	0.3354
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0185	0.0547
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0414	0.0389
Onchocerca volvulus		0.0075	0.0715	0.1787
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.038	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0056	0.0488	0.1441
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0106	0.1103	0.3257
Schistosoma mansoni	retinoic acid receptor RXR	0.0106	0.1103	0.108
Loa Loa (eye worm)	carbonic anhydrase 3	0.0138	0.1492	0.4408
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0106	0.1103	0.108
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0488	0.1441
Brugia malayi	conserved hypotetical protein	0.005	0.0414	0.1223
Echinococcus multilocularis	carbonic anhydrase II	0.0138	0.1492	0.2294
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0032	0.0185	0.0547
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0032	0.0185	0.0547
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0047	0.038	0.0355
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0047	0.038	0.5
Brugia malayi	ecdysteroid receptor	0.0106	0.1103	0.3257
Echinococcus granulosus	jun protein	0.0095	0.0966	0.147
Brugia malayi	hypothetical protein	0.0056	0.0488	0.1441
Echinococcus multilocularis	jun protein	0.0095	0.0966	0.147
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0047	0.038	0.0554
Schistosoma mansoni	amine oxidase	0.0047	0.038	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Brugia malayi	nuclear receptor NHR-88	0.005	0.0414	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0198	0.0586
Schistosoma mansoni	nuclear receptor nhr-48	0.005	0.0414	0.0389
Leishmania major	choline/Carnitine o-acyltransferase-like protein	0.0101	0.1035	0.6894
Brugia malayi	Nuclear hormone receptor-like 1	0.0056	0.0488	0.1441
Brugia malayi	steroid hormone receptor	0.0106	0.1103	0.3257
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0106	0.1103	0.3257
Brugia malayi	hypothetical protein	0.0056	0.0488	0.1441
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0106	0.1103	0.1684
Schistosoma mansoni	thyroid hormone receptor	0.0106	0.1103	0.108
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0138	0.1492	0.4408
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Echinococcus granulosus	nuclear receptor nhr 48	0.005	0.0414	0.0607
Echinococcus granulosus	lamin dm0	0.0031	0.0174	0.0231
Leishmania major	carnitine palmitoyltransferase-like protein	0.0019	0.0026	0.0045
Toxoplasma gondii	zinc finger cdgsh type protein	0.0033	0.0198	0.0666
Schistosoma mansoni	lamin	0.0031	0.0174	0.0148
Echinococcus multilocularis	carbonic anhydrase	0.0032	0.0185	0.0249
Entamoeba histolytica	hypothetical protein	0.0041	0.0303	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.005	0.0414	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Brugia malayi	nuclear hormone receptor family member nhr-6	0.005	0.0414	0.1223
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0414	0.0607
Echinococcus granulosus	FTZ F1 alpha	0.0106	0.1103	0.1684
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.0573	0.6817	0.6809
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0488	0.1441
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0026	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0019	0.0026	0.0045
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0106	0.1103	0.108
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0019	0.0057
Loa Loa (eye worm)	nuclear hormone receptor	0.005	0.0414	0.1223
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0047	0.038	0.045
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Brugia malayi	nuclear hormone receptor	0.0277	0.3195	0.9435
Schistosoma mansoni	nuclear hormone receptor	0.0106	0.1103	0.108
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0056	0.0488	0.0463
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0106	0.1103	0.108
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Echinococcus granulosus	lamin	0.0031	0.0174	0.0231
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0047	0.038	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Plasmodium falciparum	protoporphyrinogen oxidase	0.0047	0.038	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0047	0.038	0.0554
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0138	0.1492	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0277	0.3195	0.9435
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0047	0.038	1
Brugia malayi	ecdysone receptor	0.005	0.0414	0.1223
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0138	0.1492	0.4408
Echinococcus multilocularis	musashi	0.0031	0.0174	0.0231
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0101	0.1035	0.6894
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0106	0.1103	0.3257
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0674	0.8049	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0106	0.1103	0.2792
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.005	0.0414	0.0607
Toxoplasma gondii	histone lysine-specific demethylase	0.0047	0.038	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0047	0.038	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.005	0.0414	0.0607
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0303	0.0433
Brugia malayi	Nuclear hormone receptor E75	0.005	0.0414	0.1223
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0106	0.1103	0.1684
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0626	0.7468	1
Brugia malayi	nuclear receptor RXR	0.0056	0.0488	0.1441
Mycobacterium ulcerans	oxidoreductase	0.0047	0.038	0.045
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0488	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0488	0.1441
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0106	0.1103	0.1684
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0032	0.0185	0.0547
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0293	0.3386	1
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.023	0.2614	0.7719
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0095	0.0966	0.147
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0019	0.0026	0.0077
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0106	0.1103	0.1684
Schistosoma mansoni	amine oxidase	0.0047	0.038	0.0355
Brugia malayi	nuclear hormone receptor family member odr-7	0.005	0.0414	0.1223
Schistosoma mansoni	jun-related protein	0.0077	0.0747	0.0723
Brugia malayi	hypothetical protein	0.005	0.0414	0.1223
Schistosoma mansoni	hypothetical protein	0.0573	0.6817	0.6809
Echinococcus multilocularis	lamin dm0	0.0031	0.0174	0.0231
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0106	0.1103	0.1684
Entamoeba histolytica	hypothetical protein	0.0041	0.0303	0.5
Trypanosoma cruzi	carnitine O-acetyltransferase, putative	0.0019	0.0026	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0106	0.1103	0.3257
Entamoeba histolytica	hypothetical protein	0.0041	0.0303	0.5
Brugia malayi	RE40412p	0.0033	0.0198	0.0586
Schistosoma mansoni	zinc finger protein	0.005	0.0414	0.0389
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0032	0.0185	0.0547
Echinococcus granulosus	thyroid hormone receptor alpha	0.005	0.0414	0.0607
Loa Loa (eye worm)	choline O-acetyltransferase	0.0019	0.0026	0.0077
Echinococcus multilocularis	carbonic anhydrase	0.0032	0.0185	0.0249
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0019	0.0026	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0138	0.1492	0.147
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Echinococcus multilocularis	conserved hypothetical protein	0.0033	0.0198	0.027
Trypanosoma cruzi	carnitine O-palmitoyltransferase II, putative	0.0019	0.0026	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0174	0.0514
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Echinococcus granulosus	ecdysone induced protein 78C	0.0106	0.1103	0.1684
Schistosoma mansoni	hypothetical protein	0.0077	0.0747	0.0723
Brugia malayi	bZIP transcription factor family protein	0.0095	0.0966	0.2853
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0488	0.1441
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0047	0.038	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0095	0.0966	0.147
Schistosoma mansoni	hypothetical protein	0.0194	0.217	0.215
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Schistosoma mansoni	RAR-like nuclear receptor	0.0106	0.1103	0.108
Leishmania major	UDP-galactopyranose mutase	0.0047	0.038	0.245
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0047	0.038	0.0554
Echinococcus multilocularis	carbonic anhydrase	0.0032	0.0185	0.0249
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.038	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.3386	1
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.0019	0.0057
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0033	0.0198	0.0666
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0026	0.0045
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0414	0.0389
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0106	0.1103	0.108
Schistosoma mansoni	lamin	0.0031	0.0174	0.0148
Echinococcus multilocularis	FTZ F1 alpha	0.0106	0.1103	0.1684
Schistosoma mansoni	nuclear receptor	0.005	0.0414	0.0389
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0174	0.0514
Onchocerca volvulus		0.0033	0.0198	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0227	0.258	0.7619
Toxoplasma gondii	zinc finger CDGSH-type domain-containing protein	0.0033	0.0198	0.0666
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.054	0.6419	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0106	0.1103	0.3257
Onchocerca volvulus		0.0047	0.038	0.0919
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0138	0.1492	0.4408
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.0101	0.1035	0.1578
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Schistosoma mansoni	carbonic anhydrase-related	0.0032	0.0185	0.016
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.005	0.0414	0.0607
Echinococcus granulosus	carbonic anhydrase	0.0032	0.0185	0.0249
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0047	0.038	1
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.054	0.6419	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.005	0.0414	0.0607
Echinococcus granulosus	conserved hypothetical protein	0.0033	0.0198	0.027
Schistosoma mansoni	carbonic anhydrase-related	0.0032	0.0185	0.016
Trypanosoma brucei	carnitine O-acetyltransferase, putative	0.0019	0.0026	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0185	0.0547
Trypanosoma brucei	hypothetical protein, conserved	0.0019	0.0026	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0106	0.1103	0.3257
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0106	0.1103	0.3257
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.005	0.0414	0.1006
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0047	0.038	0.0554
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0026	0.0045
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0106	0.1103	0.3257
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0056	0.0488	0.0723
Brugia malayi	photoreceptor-specific nuclear receptor	0.0106	0.1103	0.3257
Echinococcus granulosus	carbonic anhydrase	0.0032	0.0185	0.0249
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0106	0.1103	0.3257
Loa Loa (eye worm)	DR-78	0.005	0.0414	0.1223
Leishmania major	carbonic anhydrase-like protein	0.0138	0.1492	1
Brugia malayi	intermediate filament protein	0.0031	0.0174	0.0514
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0106	0.1103	0.1684
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Brugia malayi	SWIRM domain containing protein	0.0047	0.038	0.1123
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0106	0.1103	0.1684
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0106	0.1103	0.3257
Brugia malayi	orphan nuclear receptor NR2E1	0.005	0.0414	0.1223
Onchocerca volvulus		0.0031	0.0174	0.0384
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.005	0.0414	0.0389
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0106	0.1103	0.1684
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0032	0.0185	0.0547
Schistosoma mansoni	carbonic anhydrase-related	0.0032	0.0185	0.016
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0047	0.038	0.245
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0026	0.0045
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0934	0.2758
Echinococcus granulosus	carbonic anhydrase	0.0032	0.0185	0.0249
Loa Loa (eye worm)	hypothetical protein	0.023	0.2614	0.7719
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0333	0.3883	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.038	0.1123
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0106	0.1103	0.1684
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0138	0.1492	0.147
Onchocerca volvulus		0.005	0.0414	0.1006
Echinococcus granulosus	carbonic anhydrase II	0.0138	0.1492	0.2294
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0106	0.1103	0.3257
Brugia malayi	nuclear receptor RXR	0.005	0.0414	0.1223
Schistosoma mansoni	thyroid hormone receptor	0.0106	0.1103	0.108
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0019	0.0057
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0106	0.1103	0.1684
Entamoeba histolytica	hypothetical protein	0.0041	0.0303	0.5
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0174	0.0148
Brugia malayi	nuclear receptor NHR-67	0.005	0.0414	0.1223
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0106	0.1103	0.1684
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0198	0.0586
Brugia malayi	Nuclear hormone receptor-like 1	0.0106	0.1103	0.3257
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0174	0.0514
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0019	0.0026	0.0077
Brugia malayi	hypothetical protein	0.0041	0.0303	0.0894
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0106	0.1103	0.1684
Schistosoma mansoni	nuclear receptor	0.005	0.0414	0.0389
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0047	0.038	0.245
Trypanosoma brucei	carbonic anhydrase-like protein	0.0138	0.1492	1
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0019	0.0026	0.0045
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0047	0.038	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0106	0.1103	0.3257
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0026	0.0045
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0101	0.1035	0.6894
Mycobacterium ulcerans	monoamine oxidase	0.0047	0.038	0.045
Onchocerca volvulus		0.0031	0.0174	0.0384
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0106	0.1103	0.3257
Loa Loa (eye worm)	hypothetical protein	0.005	0.0414	0.1223
Mycobacterium ulcerans	dehydrogenase	0.0047	0.038	0.045
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0106	0.1103	0.108
Schistosoma mansoni	hypothetical protein	0.0033	0.0198	0.0173
Brugia malayi	hypothetical protein	0.005	0.0414	0.1223
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.005	0.0414	0.0607
Leishmania major	hypothetical protein, unknown function	0.0033	0.0198	0.1215
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0138	0.1492	1
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.0101	0.1035	0.1578
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0674	0.8049	1
Echinococcus granulosus	intermediate filament protein	0.0031	0.0174	0.0231
Schistosoma mansoni	hypothetical protein	0.0032	0.0185	0.016
Trypanosoma cruzi	choline/carnitine O-acetyltransferase, putative	0.0019	0.0026	0.0045
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0033	0.0198	0.0666
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0056	0.0488	0.0463
Schistosoma mansoni	coup transcription factor	0.0106	0.1103	0.108
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0019	0.0026	0.0045
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0303	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0077
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.005	0.0414	0.1006
Echinococcus multilocularis		0.0047	0.038	0.0554
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0303	0.0277
Echinococcus multilocularis	ecdysone induced protein 78C	0.0106	0.1103	0.1684
Echinococcus multilocularis	nuclear receptor nhr 48	0.005	0.0414	0.0607
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0106	0.1103	0.3257
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0174	0.0514
Loa Loa (eye worm)	hypothetical protein	0.003	0.0167	0.0493
Echinococcus granulosus	geminin	0.0194	0.217	0.3354
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0047	0.038	0.0355
Brugia malayi	Nuclear hormone receptor-like 1	0.0056	0.0488	0.1441
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0019	0.0057
Brugia malayi	hypothetical protein	0.0047	0.038	0.1123
Loa Loa (eye worm)	nuclear receptor NHR-67	0.005	0.0414	0.1223
Brugia malayi	RE40412p	0.0033	0.0198	0.0586
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0019	0.0026	0.0045
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0032	0.0185	0.0547
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0033	0.0198	0.0666
Brugia malayi	Choline O-acetyltransferase	0.0019	0.0026	0.0077
Toxoplasma gondii	PfMNL-2 CISD1 family iron-sulfur protein, putative	0.0033	0.0198	0.0666
Brugia malayi	hypothetical protein	0.0075	0.0715	0.2113
Schistosoma mansoni	hypothetical protein	0.0041	0.0303	0.0277
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0056	0.0488	0.0723
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0106	0.1103	0.108
Onchocerca volvulus		0.023	0.2614	0.6708
Onchocerca volvulus		0.0106	0.1103	0.2792
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.005	0.0414	0.1223
Onchocerca volvulus		0.005	0.0414	0.1006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0106	0.1103	0.1684
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0106	0.1103	0.3257
Trypanosoma brucei	carnitine O-palmitoyltransferase, putative	0.0019	0.0026	0.0045
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0019	0.0026	0.0077
Onchocerca volvulus		0.0033	0.0198	0.0447
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0019	0.0057
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0019	0.0026	0.0077
Brugia malayi	tailless protein	0.005	0.0414	0.1223
Brugia malayi	amine oxidase, flavin-containing family protein	0.0047	0.038	0.1123
Leishmania major	carnitine/choline acetyltransferase, putative	0.0019	0.0026	0.0045
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0414	0.0607
Schistosoma mansoni	hypothetical protein	0.0194	0.217	0.215
Brugia malayi	Nuclear hormone receptor E75	0.005	0.0414	0.1223
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0106	0.1103	0.3257
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0106	0.1103	0.1684
Brugia malayi	nuclear receptor NHR-88	0.0106	0.1103	0.3257
Schistosoma mansoni	carbonic anhydrase	0.0032	0.0185	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0106	0.1103	0.3257
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0106	0.1103	0.108
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1103	0.3257
Onchocerca volvulus	Bile acid receptor homolog	0.0106	0.1103	0.2792
Brugia malayi	Steroid receptor seven-up type 2	0.0106	0.1103	0.3257
Brugia malayi	Choline O-acetyltransferase	0.0019	0.0026	0.0077
Echinococcus multilocularis	lamin	0.0031	0.0174	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0185	0.0547

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 63.1 uM	Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay	ChEMBL.	15982877
IC50 (binding)	= 63.1 uM	Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assay	ChEMBL.	15982877
Inhibition (binding)	= 49 uM	Percentage inhibitory activity against Plasminogen activator inhibitor-1 at 25 uM	ChEMBL.	15982877
Inhibition (binding)	= 49 uM	Percentage inhibitory activity against Plasminogen activator inhibitor-1 at 25 uM	ChEMBL.	15982877
Inhibition (binding)	= 64 uM	Percentage inhibitory activity against Plasminogen activator inhibitor-1 at 100 uM	ChEMBL.	15982877
Inhibition (binding)	= 64 uM	Percentage inhibitory activity against Plasminogen activator inhibitor-1 at 100 uM	ChEMBL.	15982877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL186301

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 327218