Detailed information for compound 327389

Basic information

Technical information
  • TDR Targets ID: 327389
  • Name: 6-(4-hydroxyphenyl)-3-(4-methylsulfonylphenyl )-4-phenylpyran-2-one
  • MW: 418.462 | Formula: C24H18O5S
  • H donors: 1 H acceptors: 4 LogP: 4.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1oc(=O)c(c(c1)c1ccccc1)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C24H18O5S/c1-30(27,28)20-13-9-18(10-14-20)23-21(16-5-3-2-4-6-16)15-22(29-24(23)26)17-7-11-19(25)12-8-17/h2-15,25H,1H3
  • InChiKey: VIVAKNAVLHNDRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-hydroxyphenyl)-3-(4-methylsulfonylphenyl)-4-phenyl-pyran-2-one
  • 6-(4-hydroxyphenyl)-3-(4-methylsulfonylphenyl)-4-phenyl-2-pyranone
  • 6-(4-hydroxyphenyl)-3-(4-mesylphenyl)-4-phenyl-pyran-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0031
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.7924 1 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0217
Echinococcus multilocularis geminin 0.0167 0.0201 0.1006
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0032 0.108
Echinococcus granulosus aldo keto reductase 0.0018 0.0013 0.0253
Brugia malayi Stress-activated protein kinase jnk-1 0.0242 0.0296 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0067 0.1334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0048 0.0044
Loa Loa (eye worm) oxidoreductase 0.0014 0.0007 0.0217
Brugia malayi steroid hormone receptor 0.001 0.0002 0.0055
Onchocerca volvulus 0.0047 0.0048 0.2323
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.514
Echinococcus granulosus hypothetical protein 0.0018 0.0013 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0055
Brugia malayi hypothetical protein 0.0229 0.0279 0.9426
Echinococcus multilocularis aldo keto reductase 0.0018 0.0013 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0212 0.4313
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0067 0.1334
Leishmania major hypothetical protein, conserved 0.0036 0.0035 0.3465
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0055
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0018 0.0013 0.0253
Trichomonas vaginalis esterase, putative 0.0036 0.0035 0.0823
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Trypanosoma brucei hexokinase 0.0078 0.0087 1
Loa Loa (eye worm) oxidoreductase 0.0018 0.0013 0.0418
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0.0013 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0173 0.5864
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0031
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0031
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0018 0.0013 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0042
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0.0013 0.0737
Onchocerca volvulus 0.0036 0.0035 0.1646
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0067 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0002 0.0055
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.1627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0035 0.0675
Trypanosoma brucei prostaglandin f synthase 0.0018 0.0013 0.0737
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0048 0.0044
Echinococcus multilocularis voltage gated potassium channel subunit 0.0018 0.0013 0.0062
Onchocerca volvulus 0.0018 0.0013 0.0543
Schistosoma mansoni hypothetical protein 0.0167 0.0201 0.4074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0013 0.0175
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0035 0.003
Entamoeba histolytica fatty acid elongase, putative 0.1029 0.1289 1
Entamoeba histolytica aldose reductase, putative 0.0018 0.0013 0.0046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0164 0.016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0048 0.264
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0221
Brugia malayi ecdysteroid receptor 0.001 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0688
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0048 0.0324
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.0508
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0007 0.0002
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0032 0.0026
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0142 0.481
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0048 0.1604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0055
Onchocerca volvulus 0.0014 0.0007 0.0245
Leishmania major protein kinase, putative 0.0065 0.0071 0.7968
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0008
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0032 0.016
Echinococcus multilocularis protein patched 0.0041 0.0041 0.0205
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0007 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0002 0.0055
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0007 0.0221
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0071 0.7968
Entamoeba histolytica hypothetical protein 0.0071 0.0079 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0.0013 0.0737
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0035 0.0823
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0347 1
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0048 0.1608
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Entamoeba histolytica aldose reductase, putative 0.0018 0.0013 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0048 0.1608
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.0768
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0067 0.0334
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0.0013 0.0175
Loa Loa (eye worm) hexokinase 0.0024 0.002 0.066
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.002 0.0014
Leishmania major hypothetical protein, conserved 0.0034 0.0032 0.3152
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0007 0.0221
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.002 0.1676
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0079 0.1619
Echinococcus granulosus hexokinase 0.0078 0.0087 0.1782
Brugia malayi TAR-binding protein 0.0061 0.0067 0.2258
Loa Loa (eye worm) beta-lactamase 0.0036 0.0035 0.1165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.112
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Plasmodium falciparum hexokinase 0.0078 0.0087 0.0081
Brugia malayi NADH-dependent xylose reductase 0.0018 0.0013 0.0423
Entamoeba histolytica hypothetical protein 0.0071 0.0079 0.0568
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0035 0.003
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0279 0.1398
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0242 0.0296 0.1483
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0071 0.1421
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0071 0.7968
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0071 0.7968
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Echinococcus granulosus c-Jun N-terminal kinases 0.0242 0.0296 0.6034
Echinococcus multilocularis cpg binding protein 0.0029 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.112
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.1627
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.514
Onchocerca volvulus 0.0047 0.0048 0.2332
Brugia malayi Protein kinase domain containing protein 0.0065 0.0071 0.2401
Schistosoma mansoni hypothetical protein 0.01 0.0115 0.2325
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0048 0.0042
Trypanosoma brucei aldo-keto reductase, putative 0.0018 0.0013 0.0737
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0007 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0221
Mycobacterium tuberculosis Conserved protein 0.0036 0.0035 0.003
Brugia malayi beta-lactamase family protein 0.0036 0.0035 0.1169
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0168 0.0202 0.6821
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0035 0.3465
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Echinococcus multilocularis hexokinase 0.0078 0.0087 0.0438
Echinococcus multilocularis expressed conserved protein 0.009 0.0102 0.0513
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0168 0.0202 0.6822
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.112
Mycobacterium ulcerans hypothetical protein 0.0036 0.0035 0.0028
Leishmania major hypothetical protein, conserved 0.0024 0.002 0.1676
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0055
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0002 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0056 0.6096
Brugia malayi Hexokinase family protein 0.0049 0.0051 0.172
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0018 0.0013 0.0379
Echinococcus granulosus hexokinase type 2 0.0078 0.0087 0.1782
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.1992 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Loa Loa (eye worm) RNA binding protein 0.0061 0.0067 0.2255
Brugia malayi hexokinase type II 0.0025 0.002 0.0693
Mycobacterium ulcerans hypothetical protein 0.0047 0.0048 0.0042
Schistosoma mansoni pol-related 0.0018 0.0013 0.0223
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.002 0.1676
Echinococcus granulosus hexokinase 0.0078 0.0087 0.1782
Echinococcus granulosus tar DNA binding protein 0.0061 0.0067 0.136
Onchocerca volvulus 0.0018 0.0013 0.0543
Plasmodium falciparum aldo-keto reductase, putative 0.0018 0.0013 0.0006
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0035 0.003
Schistosoma mansoni aldo-keto reductase 0.0018 0.0013 0.0223
Loa Loa (eye worm) oxidoreductase 0.0018 0.0013 0.0418
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0173 0.5866
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0013 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0002 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0031
Echinococcus multilocularis aldo keto reductase 0.0018 0.0013 0.0062
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.0768
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0164 0.0158
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0048 0.264
Brugia malayi RNA binding protein 0.0061 0.0067 0.2258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0045 0.0921
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0018 0.0013 0.0418
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0024 0.0821
Onchocerca volvulus 0.0036 0.0035 0.1646
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0347 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0055
Mycobacterium tuberculosis Conserved protein 0.0036 0.0035 0.003
Toxoplasma gondii aldo-keto reductase 0.0018 0.0013 0.0737
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0041 0.0834
Loa Loa (eye worm) hypothetical protein 0.005 0.0053 0.1775
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0035 0.0675
Brugia malayi beta-lactamase family protein 0.0036 0.0035 0.1169
Mycobacterium ulcerans hypothetical protein 0.0018 0.0013 0.0006
Entamoeba histolytica fatty acid elongase, putative 0.1029 0.1289 1
Echinococcus granulosus hypothetical protein 0.0063 0.0069 0.1397
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Entamoeba histolytica hypothetical protein 0.0071 0.0079 0.0568
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Onchocerca volvulus 0.0014 0.0007 0.0245
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0032 0.3152
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.0508
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0018 0.0013 0.0423
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0279 0.5688
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0003 0.006
Brugia malayi Augmenter of liver regeneration 0.0034 0.0032 0.1084
Onchocerca volvulus 0.0078 0.0087 0.4288
Mycobacterium ulcerans beta-lactamase 0.0036 0.0035 0.0028
Brugia malayi hypothetical protein 0.0024 0.002 0.068
Loa Loa (eye worm) oxidoreductase 0.0018 0.0013 0.0418
Onchocerca volvulus 0.0018 0.0013 0.0543
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0035 0.003
Echinococcus granulosus voltage gated potassium channel subunit 0.0018 0.0013 0.0253
Brugia malayi Hexokinase family protein 0.0024 0.002 0.0664
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.2315
Leishmania major protein kinase, putative 0.0065 0.0071 0.7968
Onchocerca volvulus 0.0014 0.0007 0.0245
Onchocerca volvulus 0.0049 0.0051 0.246
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.002 0.1676
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0035 0.003
Schistosoma mansoni hypothetical protein 0.0071 0.0079 0.1593
Loa Loa (eye worm) oxidoreductase 0.0018 0.0013 0.0418
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0168 0.0202 0.4116
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0035 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0035 0.0823
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0065 0.0071 0.7968
Mycobacterium tuberculosis Probable oxidoreductase 0.0018 0.0013 0.0008
Trypanosoma brucei hexokinase 0.0078 0.0087 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0048 0.0238
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0347 0.2653
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0018 0.0013 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0041 0.0205
Loa Loa (eye worm) hypothetical protein 0.0146 0.0173 0.5864
Onchocerca volvulus 0.0018 0.0013 0.0543
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0064 0.1274
Toxoplasma gondii ABC1 family protein 0.0036 0.0035 0.3465
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.1627
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0221
Mycobacterium leprae Possible oxidoreductase 0.0018 0.0013 0.0379
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0242 0.0296 1
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0048 0.0968
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Schistosoma mansoni patched 1 0.0041 0.0041 0.0806
Echinococcus granulosus cpg binding protein 0.0029 0.0026 0.0537
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0008
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.7924 1 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0168 0.0202 0.1011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.1624
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0048 0.0238
Plasmodium falciparum protein serine/threonine kinase-1 0.0065 0.0071 0.0064
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0055
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0164 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0035 0.0823
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0031 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0173 0.5866
Leishmania major aldo-keto reductase-like protein 0.0018 0.0013 0.0737
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0018 0.0013 0.0737
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0202 0.4098
Brugia malayi MH2 domain containing protein 0.0121 0.0142 0.4813
Echinococcus multilocularis hexokinase 0.0078 0.0087 0.0438
Brugia malayi beta-lactamase 0.0036 0.0035 0.1169
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0035 0.3465
Toxoplasma gondii hexokinase 0.0078 0.0087 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0035 0.0823
Trypanosoma cruzi hexokinase, putative 0.0078 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0688
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0041 0.1382
Schistosoma mansoni aldo-keto reductase 0.0018 0.0013 0.0223
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0676
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Giardia lamblia Kinase, CMGC CLK 0.0065 0.0071 0.1749
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0018 0.0013 0.0737
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0031
Onchocerca volvulus 0.0078 0.0087 0.4288
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0031
Mycobacterium ulcerans oxidoreductase 0.0018 0.0013 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0142 0.481
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0033 0.0027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.0768
Echinococcus granulosus aldo keto reductase 0.0018 0.0013 0.0253
Echinococcus multilocularis hexokinase 0.0078 0.0087 0.0438
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.094
Echinococcus granulosus hexokinase 0.0078 0.0087 0.1782
Loa Loa (eye worm) hypothetical protein 0.0053 0.0056 0.1898
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.7924 1 1
Brugia malayi hypothetical protein 0.0016 0.0009 0.031
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0035 0.0028
Schistosoma mansoni survival motor neuron protein 0.0047 0.0048 0.0956
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0032 0.3152
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0168 0.0202 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0067 0.2258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0045 0.0893
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0067 0.2255
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0217
Leishmania major hexokinase, putative 0.0078 0.0087 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.049 1
Trypanosoma cruzi aldo-keto reductase 0.0018 0.0013 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0055
Loa Loa (eye worm) hexokinase 0.0078 0.0087 0.2954
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0.0013 0.0175
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0033 0.0027
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0007 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0045 0.0921
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0347 0.2653
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0018 0.0013 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0045 0.153
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0007 0.0101
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0035 0.0703
Brugia malayi Protein kinase domain containing protein 0.0168 0.0202 0.6822
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0065 0.0071 0.2398
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.1382
Onchocerca volvulus Hexokinase homolog 0.0049 0.0051 0.246
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Brugia malayi hexokinase 0.0078 0.0087 0.2957
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.011 0.055
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.1624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0045 0.0893
Echinococcus granulosus aldo keto reductase 0.0018 0.0013 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0035 0.3465
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0048 0.0042
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.0768
Mycobacterium leprae Probable lipase LipE 0.0036 0.0035 0.178
Loa Loa (eye worm) hypothetical protein 0.0229 0.0279 0.9425
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0048 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0079 0.0398
Onchocerca volvulus 0.0014 0.0007 0.0245
Entamoeba histolytica hypothetical protein 0.0071 0.0079 0.0568
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0.0013 0.0175
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.011 0.2238
Onchocerca volvulus 0.0018 0.0013 0.0543
Echinococcus multilocularis 0.0063 0.0069 0.0343
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0032 0.3152
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0296 0.6022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0217
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0071 0.7968
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0079 0.1593
Plasmodium falciparum aldehyde reductase, putative 0.0018 0.0013 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0035 0.0028
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0032 0.3152
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0035 0.178
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0067 0.1334
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0032 0.0026
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.002 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0048 0.0324
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0035 0.1169
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.002 0.1676
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Echinococcus multilocularis aldo keto reductase 0.0018 0.0013 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0035 0.1165
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0065 0.0071 0.7968
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.7924 1 0.5
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.094
Entamoeba histolytica fatty acid elongase, putative 0.1029 0.1289 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0047 0.0048 0.0956
Echinococcus granulosus expressed conserved protein 0.009 0.0102 0.2089
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0002 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.514
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Schistosoma mansoni hypothetical protein 0.0167 0.0201 0.4074
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.7924 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.011 0.0804
Schistosoma mansoni hypothetical protein 0.0046 0.0048 0.094
Echinococcus granulosus GPCR family 2 0.0046 0.0048 0.0968
Schistosoma mansoni hypothetical protein 0.0396 0.049 1
Entamoeba histolytica aldose reductase, putative 0.0018 0.0013 0.0046
Trypanosoma brucei hexokinase, putative 0.0078 0.0087 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0048 0.1633
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0007 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0041 0.0834
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0161 0.081
Onchocerca volvulus 0.0078 0.0087 0.4288
Entamoeba histolytica hexokinase 1 0.0078 0.0087 0.063
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0071 0.1893
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0042
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0032 0.3152
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0048 0.0042
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.7924 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0048 0.0324
Trypanosoma cruzi hexokinase, putative 0.0078 0.0087 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0115 0.3895
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Entamoeba histolytica fatty acid elongase, putative 0.1029 0.1289 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0007 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0045 0.0226
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0033 0.0027
Echinococcus multilocularis GPCR, family 2 0.0046 0.0048 0.0238
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0032 0.0651
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0007 0.0131
Brugia malayi CHE-14 protein 0.0041 0.0041 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0041 0.1011
Echinococcus multilocularis hexokinase type 2 0.0078 0.0087 0.0438
Echinococcus granulosus dual specificity protein kinase clk2 0.0065 0.0071 0.1447
Entamoeba histolytica hexokinase 2 0.0078 0.0087 0.063
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0018 0.0013 0.0737
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0033 0.0029
Brugia malayi hypothetical protein 0.0071 0.0079 0.2686
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0055
Brugia malayi Hexokinase family protein 0.0078 0.0087 0.2957
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0032 0.3152
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0007 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0008
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0065 0.0071 0.7968
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0042
Echinococcus granulosus geminin 0.0167 0.0201 0.4093
Schistosoma mansoni potassium channel beta 0.0018 0.0013 0.0223
Plasmodium vivax aldehyde reductase, putative 0.0018 0.0013 0.0006
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0.0013 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0221
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Loa Loa (eye worm) hexokinase type II 0.0078 0.0087 0.2954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0045 0.0893
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.7924 1 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0168 0.0202 0.6821
Loa Loa (eye worm) hypothetical protein 0.01 0.0115 0.3892
Echinococcus multilocularis aldo keto reductase 0.0018 0.0013 0.0062
Onchocerca volvulus 0.0018 0.0013 0.0543
Loa Loa (eye worm) hexokinase 0.0078 0.0087 0.2954
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0018 0.0013 0.0423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0008
Trypanosoma brucei aldo/keto reductase, putative 0.0018 0.0013 0.0737
Schistosoma mansoni cpg binding protein 0.0028 0.0024 0.0467
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0.0013 0.0175
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0018 0.0013 0.0175
Mycobacterium tuberculosis Conserved protein 0.0036 0.0035 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0048 0.1604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0065 0.0071 0.0064
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0013 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0095 0.011 0.3709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.011 0.3712
Leishmania major hexokinase, putative 0.0078 0.0087 1
Loa Loa (eye worm) oxidoreductase 0.0018 0.0013 0.0418
Mycobacterium tuberculosis Conserved protein 0.0018 0.0013 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0031 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0071 0.1421
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0067 0.2255
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0048 0.0968
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0055
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0161 0.3294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0045 0.0226
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0217
Leishmania major prostaglandin f synthase, putative 0.0018 0.0013 0.0737
Mycobacterium ulcerans lipase LipD 0.0036 0.0035 0.0028
Echinococcus multilocularis protein dispatched 1 0.0047 0.0048 0.0242
Brugia malayi Protein kinase domain containing protein 0.0176 0.0212 0.7178
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0035 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0055
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.002 0.0014
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Toxoplasma gondii aldose reductase, putative 0.0018 0.0013 0.0737
Echinococcus multilocularis dual specificity protein kinase clk2 0.0065 0.0071 0.0356
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0279 0.0275
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0018 0.0013 0.0737
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0008
Brugia malayi CXXC zinc finger family protein 0.0028 0.0024 0.0826
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0035 0.0028
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0018 0.0013 0.0423
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0035 0.003
Plasmodium vivax hexokinase, putative 0.0078 0.0087 0.0081
Onchocerca volvulus 0.0028 0.0024 0.1139
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0018 0.0013 0.0062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0035 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.1165
Onchocerca volvulus 0.0018 0.0013 0.0543
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0007 0.0002
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0018 0.0013 0.0737
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0045 0.1526
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0347 1
Entamoeba histolytica fatty acid elongase, putative 0.1029 0.1289 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0067 0.1334
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0007 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.049 0.2458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.1624
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0176 0.0212 0.7176
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0018 0.0013 0.0253
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0112 0.2253
Loa Loa (eye worm) hexokinase 0.0049 0.0051 0.1716
Onchocerca volvulus 0.0036 0.0035 0.1646
Schistosoma mansoni hexokinase 0.0078 0.0087 0.1757
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0013 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0002 0.0051

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 1 ChEMBL. 15267236
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 2 ChEMBL. 15267236
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 1 ChEMBL. 15267236
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 2 ChEMBL. 15267236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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