Detailed information for compound 327434

Basic information

Technical information
  • TDR Targets ID: 327434
  • Name: 4-chloro-N-(4-chlorophenyl)sulfonyl-2-ethylbe nzamide
  • MW: 358.24 | Formula: C15H13Cl2NO3S
  • H donors: 1 H acceptors: 3 LogP: 4.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc(Cl)ccc1C(=O)NS(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C15H13Cl2NO3S/c1-2-10-9-12(17)5-8-14(10)15(19)18-22(20,21)13-6-3-11(16)4-7-13/h3-9H,2H2,1H3,(H,18,19)
  • InChiKey: GMFXLDJYMOMKKL-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-chloro-N-(4-chlorophenyl)sulfonyl-2-ethyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0112 0.3268 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0397 0.037
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0082 0.2321 0.2299
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0184 0.5586 1
Toxoplasma gondii beta-tubulin, putative 0.0099 0.2867 0.2375
Trypanosoma cruzi zeta tubulin, putative 0.0043 0.1074 0.0458
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0646 0.062
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0397 0.0397
Loa Loa (eye worm) tubulin alpha-3 chain 0.0128 0.3793 0.3776
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0397 0.037
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0028 0.0028
Trypanosoma brucei zeta tubulin, putative 0.0043 0.1074 0.0458
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0397 0.057
Echinococcus granulosus glutamate synthase 0.003 0.0646 0.062
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Trypanosoma brucei beta tubulin 0.0099 0.2867 0.2375
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0924 0.106
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0397 0.037
Loa Loa (eye worm) hypothetical protein 0.0141 0.421 0.4194
Echinococcus granulosus tubulin alpha chain 0.0184 0.5586 0.5574
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.003 0.0646 0.062
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0112 0.3268 0.2803
Plasmodium vivax tubulin beta chain, putative 0.0099 0.2867 0.2375
Toxoplasma gondii beta tubulin 0.0099 0.2867 0.2375
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Schistosoma mansoni coup transcription factor 0.0022 0.0397 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0397 0.037
Echinococcus multilocularis tubulin alpha 3 chain 0.0184 0.5586 0.5574
Echinococcus granulosus tubulin alpha 3 chain 0.0184 0.5586 0.5574
Brugia malayi nuclear receptor NHR-88 0.0022 0.0397 0.037
Echinococcus granulosus beta tubulin 0.0099 0.2867 0.2847
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0397 0.037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0397 0.037
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0141 0.421 0.7215
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0397 0.037
Brugia malayi glutamate synthase 0.003 0.0646 0.062
Trichomonas vaginalis tubulin epsilon chain, putative 0.0184 0.5586 1
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0397 0.037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0397 0.037
Mycobacterium tuberculosis Cell division protein FtsZ 0.0043 0.1074 0.0458
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0924 0.0297
Toxoplasma gondii alpha tubulin TUBA1 0.0184 0.5586 0.5281
Echinococcus granulosus sulfide:quinone oxidoreductase 0.003 0.0646 0.062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0214 0.6535 0.6525
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0112 0.3268 1
Plasmodium falciparum thioredoxin reductase 0.0323 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0924 0.0898
Trichomonas vaginalis tubulin gamma chain, putative 0.0099 0.2867 0.4496
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0128 0.3793 0.6371
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0112 0.3268 0.3268
Loa Loa (eye worm) hypothetical protein 0.003 0.0646 0.062
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0112 0.3268 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0646 0.062
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0924 0.0297
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0397 0.057
Loa Loa (eye worm) tubulin alpha chain 0.0184 0.5586 0.5574
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.003 0.0646 0.062
Schistosoma mansoni alpha tubulin 0.0184 0.5586 0.5586
Trypanosoma cruzi alpha tubulin, putative 0.0184 0.5586 0.5281
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0397 0.037
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0112 0.3268 0.2803
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0397 0.037
Treponema pallidum NADH oxidase 0.0112 0.3268 1
Loa Loa (eye worm) thioredoxin reductase 0.0323 1 1
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Trypanosoma cruzi zeta tubulin, putative 0.0043 0.1074 0.0458
Echinococcus multilocularis tubulin delta chain 0.0043 0.1074 0.1049
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0646 0.062
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0112 0.3268 0.2803
Trichomonas vaginalis tubulin epsilon chain, putative 0.0099 0.2867 0.4496
Echinococcus multilocularis tubulin epsilon chain 0.0099 0.2867 0.2847
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0397 0.037
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0043 0.1074 0.0458
Trichomonas vaginalis tubulin epsilon chain, putative 0.0099 0.2867 0.4496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.004
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0112 0.3268 0.3249
Echinococcus multilocularis Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Plasmodium vivax delta tubulin, putative 0.0043 0.1074 0.0458
Trypanosoma brucei beta tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0028 0.0028
Schistosoma mansoni zinc finger protein 0.001 0.0028 0.0028
Loa Loa (eye worm) tubulin beta-4 chain 0.0099 0.2867 0.2847
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Brugia malayi steroid hormone receptor 0.0022 0.0397 0.037
Mycobacterium leprae cell division protein FtsZ 0.0043 0.1074 0.1634
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0112 0.3268 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.3268 0.2803
Echinococcus multilocularis Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Trypanosoma brucei beta tubulin 0.0099 0.2867 0.2375
Trichomonas vaginalis mercuric reductase, putative 0.0112 0.3268 0.5308
Brugia malayi alpha-tubulin 0.0184 0.5586 0.5574
Giardia lamblia Beta tubulin 0.0099 0.2867 0.4496
Trypanosoma brucei epsilon tubulin 0.0099 0.2867 0.2375
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0056 0.1492 0.1711
Echinococcus granulosus tubulin alpha 1C chain 0.0184 0.5586 0.5574
Trypanosoma brucei alpha tubulin 0.0184 0.5586 0.5281
Trypanosoma cruzi trypanothione reductase, putative 0.0112 0.3268 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0397 0.037
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0397 0.037
Plasmodium falciparum thioredoxin reductase 0.0112 0.3268 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Echinococcus granulosus alpha tubulin 0.0184 0.5586 0.5574
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0924 0.0297
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0112 0.3268 0.2803
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0397 0.037
Schistosoma mansoni disulfide oxidoreductase 0.003 0.0646 0.0646
Echinococcus multilocularis tubulin gamma 1 chain 0.0099 0.2867 0.2847
Plasmodium falciparum glutathione reductase 0.0323 1 1
Plasmodium falciparum tubulin gamma chain 0.0099 0.2867 0.2375
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Trypanosoma brucei alpha tubulin 0.0184 0.5586 0.5281
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0924 0.0898
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Trichomonas vaginalis tubulin, putative 0.0043 0.1074 0.0867
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0397 0.037
Trichomonas vaginalis glutathione reductase, putative 0.0112 0.3268 0.5308
Giardia lamblia Alpha-tubulin 0.0184 0.5586 1
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0397 0.0397
Echinococcus multilocularis peroxisome assembly protein 26 0.0184 0.5586 0.5574
Trichomonas vaginalis tubulin gamma chain, putative 0.0099 0.2867 0.4496
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0397 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Schistosoma mansoni tubulin subunit alpha 0.0043 0.1074 0.1074
Schistosoma mansoni tubulin subunit alpha 0.0184 0.5586 0.5586
Echinococcus granulosus tubulin alpha chain 0.0184 0.5586 0.5574
Brugia malayi Tubulin beta-1 chain 0.0099 0.2867 0.2847
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0924 0.0563
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0397 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0397 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.004
Trichomonas vaginalis tubulin gamma chain, putative 0.0099 0.2867 0.4496
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0099 0.2867 0.2375
Schistosoma mansoni sulfide quinone reductase 0.003 0.0646 0.0646
Plasmodium falciparum alpha tubulin 2 0.0184 0.5586 0.5281
Echinococcus granulosus peroxisome assembly protein 26 0.0184 0.5586 0.5574
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0068 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0397 0.057
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni tubulin subunit epsilon 0.0099 0.2867 0.2867
Echinococcus multilocularis tubulin beta 1 chain 0.0099 0.2867 0.2847
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0112 0.3268 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0323 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0397 0.037
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0397 0.037
Echinococcus multilocularis tubulin alpha 1C chain 0.0184 0.5586 0.5574
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0646 0.062
Brugia malayi nuclear hormone receptor 0.0022 0.0397 0.037
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0099 0.2867 0.2847
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0068 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0397 0.037
Schistosoma mansoni tubulin subunit alpha 0.0184 0.5586 0.5586
Brugia malayi Tubulin alpha-2 chain 0.0184 0.5586 0.5574
Echinococcus multilocularis tubulin alpha 3 chain 0.0184 0.5586 0.5574
Trypanosoma brucei tubulin delta chain 0.0043 0.1074 0.0458
Echinococcus granulosus Tubulin beta 2C chain 0.0099 0.2867 0.2847
Onchocerca volvulus 0.0022 0.0397 0.057
Echinococcus granulosus Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.3268 1
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Echinococcus granulosus Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Loa Loa (eye worm) tubulin beta chain 0.0099 0.2867 0.2847
Brugia malayi Tubulin alpha chain 0.0043 0.1074 0.1049
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.3268 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0056 0.1492 0.1711
Brugia malayi Tubulin alpha chain 0.0184 0.5586 0.5574
Echinococcus granulosus tubulin epsilon chain 0.0099 0.2867 0.2847
Loa Loa (eye worm) alpha-tubulin 0.0184 0.5586 0.5574
Schistosoma mansoni hypothetical protein 0.003 0.0646 0.0646
Treponema pallidum cell division protein FtsZ 0.0043 0.1074 0.1634
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0068 0.0068
Brugia malayi STAT protein, DNA binding domain containing protein 0.0153 0.4589 0.4574
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0082 0.2321 0.2299
Trypanosoma brucei trypanothione reductase 0.0323 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0141 0.421 0.4194
Leishmania major delta tubulin, putative 0.0043 0.1074 0.0458
Trichomonas vaginalis tubulin epsilon chain, putative 0.0043 0.1074 0.0867
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0646 0.062
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.003 0.0646 0.062
Schistosoma mansoni glutamate synthase 0.003 0.0646 0.0646
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Echinococcus multilocularis tubulin alpha chain 0.0184 0.5586 0.5574
Plasmodium falciparum glutathione reductase 0.0112 0.3268 0.2803
Echinococcus granulosus tubulin gamma 1 chain 0.0099 0.2867 0.2847
Echinococcus granulosus Tubulin beta 2C chain 0.0099 0.2867 0.2847
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0397 0.0397
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0924 0.0898
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0397 0.037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Trichomonas vaginalis tubulin, putative 0.0056 0.1492 0.1711
Brugia malayi hypothetical protein 0.0012 0.0068 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0068 0.0068
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0924 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0397 0.037
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0112 0.3268 0.2803
Loa Loa (eye worm) BEN-1 protein 0.0099 0.2867 0.2847
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0323 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0028 0.0028
Plasmodium falciparum tubulin epsilon chain, putative 0.0099 0.2867 0.2375
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0397 0.037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0112 0.3268 0.2803
Brugia malayi ecdysteroid receptor 0.0022 0.0397 0.037
Schistosoma mansoni tubulin subunit beta 0.0043 0.1074 0.1074
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.004
Schistosoma mansoni tubulin subunit gamma 0.0099 0.2867 0.2867
Loa Loa (eye worm) tubulin alpha 2 0.0141 0.421 0.4194
Leishmania major zeta tubulin, putative 0.0043 0.1074 0.0458
Toxoplasma gondii beta-1 tubulin, putative 0.0099 0.2867 0.2375
Leishmania major gamma-tubulin 0.0099 0.2867 0.2375
Brugia malayi nuclear receptor RXR 0.0012 0.0068 0.004
Schistosoma mansoni alpha tubulin 0.0184 0.5586 0.5586
Loa Loa (eye worm) programmed cell death 8 0.003 0.0646 0.062
Schistosoma mansoni ap endonuclease 0.0038 0.0924 0.0924
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0112 0.3268 0.2803
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0397 0.037
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0112 0.3268 0.2803
Echinococcus granulosus tubulin beta 4A class IVa 0.0099 0.2867 0.2847
Loa Loa (eye worm) hypothetical protein 0.0128 0.3793 0.3776
Echinococcus granulosus Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0924 0.106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0924 0.0297
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0397 0.037
Leishmania major trypanothione reductase 0.0323 1 1
Trypanosoma cruzi tubulin delta chain 0.0043 0.1074 0.0458
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0397 0.0397
Brugia malayi beta-tubulin, identical 0.0099 0.2867 0.2847
Trypanosoma brucei beta tubulin 0.0099 0.2867 0.2375
Trypanosoma brucei beta tubulin 0.0099 0.2867 0.2375
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0112 0.3268 0.2803
Echinococcus granulosus tubulin alpha chain 0.0184 0.5586 0.5574
Echinococcus multilocularis tubulin subunit beta 0.0099 0.2867 0.2847
Onchocerca volvulus 0.003 0.0646 0.0954
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0141 0.421 0.4194
Trypanosoma brucei alpha tubulin, putative 0.0056 0.1492 0.0904
Loa Loa (eye worm) BEN-1 protein 0.0099 0.2867 0.2847
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Echinococcus granulosus tubulin alpha chain 0.0184 0.5586 0.5574
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Echinococcus granulosus tubulin subunit TubB 0.0184 0.5586 0.5574
Echinococcus multilocularis tubulin alpha chain 0.0184 0.5586 0.5574
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus multilocularis Tubulin beta 2C chain 0.0099 0.2867 0.2847
Schistosoma mansoni tubulin subunit alpha 0.0184 0.5586 0.5586
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0924 0.0898
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0397 0.037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0924 0.0563
Schistosoma mansoni glutamate synthase 0.003 0.0646 0.0646
Plasmodium falciparum alpha tubulin 1 0.0184 0.5586 0.5281
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0397 0.037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0397 0.0397
Echinococcus multilocularis beta tubulin 0.0099 0.2867 0.2847
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus granulosus tubulin delta chain 0.0043 0.1074 0.1049
Trichomonas vaginalis tubulin, putative 0.0056 0.1492 0.1711
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0112 0.3268 1
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Echinococcus multilocularis Tubulin beta 2C chain 0.0099 0.2867 0.2847
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0924 0.0563
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0397 0.037
Trichomonas vaginalis tubulin gamma chain, putative 0.0043 0.1074 0.0867
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Trichomonas vaginalis tubulin beta chain, putative 0.0184 0.5586 1
Trypanosoma cruzi epsilon tubulin, putative 0.0099 0.2867 0.2375
Echinococcus granulosus tubulin alpha 0.0099 0.2867 0.2847
Loa Loa (eye worm) tubulin alpha 2 0.0085 0.2417 0.2396
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Toxoplasma gondii NADPH-glutathione reductase 0.0112 0.3268 0.2803
Plasmodium falciparum tubulin beta chain 0.0099 0.2867 0.2375
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0397 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0397 0.037
Trypanosoma brucei alpha tubulin 0.0184 0.5586 0.5281
Brugia malayi Tubulin beta chain 0.0043 0.1074 0.1049
Trypanosoma brucei epsilon tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0397 0.0397
Entamoeba histolytica tubulin family protein 0.0099 0.2867 0.4496
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0397 0.037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0397 0.0397
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.003 0.0646 0.062
Onchocerca volvulus Tyrosine kinase homolog 0.0213 0.6504 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0184 0.5586 0.5574
Brugia malayi tubulin alpha-2 chain 0.0184 0.5586 0.5574
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0112 0.3268 0.3249
Loa Loa (eye worm) tubulin beta-2A chain 0.0099 0.2867 0.2847
Echinococcus multilocularis Tubulin beta 2C chain 0.0099 0.2867 0.2847
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Entamoeba histolytica tubulin alpha-1 chain 0.0184 0.5586 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0112 0.3268 0.3249
Giardia lamblia Beta tubulin 0.0099 0.2867 0.4496
Trypanosoma brucei tubulin gamma chain 0.0099 0.2867 0.2375
Echinococcus granulosus Tubulin beta 2C chain 0.0099 0.2867 0.2847
Schistosoma mansoni tubulin subunit delta 0.0043 0.1074 0.1074
Brugia malayi Tubulin alpha-2 chain 0.0184 0.5586 0.5574
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0397 0.037
Echinococcus multilocularis hypothetical protein 0.0184 0.5586 0.5574
Brugia malayi Cell division protein ftsZ 0.0043 0.1074 0.1049
Onchocerca volvulus 0.0056 0.1492 0.226
Trypanosoma cruzi tubulin gamma chain 0.0099 0.2867 0.2375
Onchocerca volvulus 0.0208 0.6348 0.976
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0397 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.004
Brugia malayi Tubulin gamma chain 0.0099 0.2867 0.2847
Plasmodium vivax tubulin epsilon chain, putative 0.0099 0.2867 0.2375
Loa Loa (eye worm) alpha-tubulin 0.0184 0.5586 0.5574
Echinococcus granulosus tubulin beta 1 chain 0.0099 0.2867 0.2847
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Loa Loa (eye worm) tubulin alpha chain 0.0184 0.5586 0.5574
Trichomonas vaginalis tubulin alpha chain, putative 0.0099 0.2867 0.4496
Plasmodium falciparum tubulin delta chain, putative 0.0043 0.1074 0.0458
Entamoeba histolytica tubulin alpha chain, putative 0.0184 0.5586 1
Echinococcus granulosus Tubulin beta 2C chain 0.0099 0.2867 0.2847
Loa Loa (eye worm) hypothetical protein 0.0184 0.5586 0.5574
Mycobacterium ulcerans cell division protein FtsZ 0.0043 0.1074 0.1634
Echinococcus multilocularis tubulin alpha 0.0099 0.2867 0.2847
Trichomonas vaginalis tubulin beta chain, putative 0.0099 0.2867 0.4496
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Plasmodium vivax tubulin alpha chain, putative 0.0184 0.5586 0.5281
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.003 0.0646 0.062
Plasmodium vivax thioredoxin reductase, putative 0.0323 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0056 0.1492 0.1711
Echinococcus multilocularis Tubulin beta 2C chain 0.0099 0.2867 0.2847
Giardia lamblia Beta tubulin 0.0099 0.2867 0.4496
Echinococcus multilocularis tubulin subunit TubB 0.0184 0.5586 0.5574
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0397 0.0397
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0924 0.106
Loa Loa (eye worm) tubulin gamma chain 0.0099 0.2867 0.2847
Plasmodium vivax tubulin gamma chain, putative 0.0099 0.2867 0.2375
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0068 0.004
Trichomonas vaginalis tubulin epsilon chain, putative 0.0184 0.5586 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0646 0.062
Loa Loa (eye worm) tubulin beta-1 chain 0.0099 0.2867 0.2847
Leishmania major epsilon tubulin, putative 0.0099 0.2867 0.2375
Echinococcus granulosus Tubulin beta 2C chain 0.0099 0.2867 0.2847
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0028
Brugia malayi tubulin alpha chain - mouse 0.0184 0.5586 0.5574
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0924 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0397 0.037
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Plasmodium vivax tubulin alpha chain, putative 0.0184 0.5586 0.5281
Echinococcus multilocularis beta tubulin 0.0099 0.2867 0.2847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0397 0.037
Echinococcus multilocularis tubulin alpha chain 0.0184 0.5586 0.5574
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0397 0.0397
Echinococcus multilocularis tubulin alpha chain 0.0184 0.5586 0.5574
Trichomonas vaginalis tubulin alpha chain, putative 0.0056 0.1492 0.1711
Giardia lamblia Delta tubulin 0.0043 0.1074 0.0867
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.003 0.0646 0.062
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0112 0.3268 0.2803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0112 0.3268 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0112 0.3268 0.2803
Brugia malayi hypothetical protein 0.0012 0.0068 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0397 0.0397
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0112 0.3268 1
Trichomonas vaginalis tubulin, putative 0.0099 0.2867 0.4496
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0043 0.1074 0.1634
Trichomonas vaginalis tubulin alpha chain, putative 0.0056 0.1492 0.1711
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0068 0.004
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Trypanosoma cruzi beta tubulin, putative 0.0099 0.2867 0.2375
Leishmania major beta tubulin 0.0099 0.2867 0.2375
Echinococcus granulosus tubulin alpha chain 0.0184 0.5586 0.5574
Echinococcus multilocularis tubulin alpha 1C chain 0.0184 0.5586 0.5574
Trypanosoma cruzi trypanothione reductase, putative 0.0323 1 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0112 0.3268 0.5308
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.1074 0.0867
Echinococcus granulosus tubulin subunit beta 0.0099 0.2867 0.2847
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0043 0.1074 0.0867
Loa Loa (eye worm) beta-tubulin 0.0099 0.2867 0.2847
Echinococcus granulosus tubulin alpha 1C chain 0.0184 0.5586 0.5574
Brugia malayi Thioredoxin reductase 0.0323 1 1
Schistosoma mansoni ap endonuclease 0.0038 0.0924 0.0924
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0397 0.037
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.003 0.0646 0.062
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.003 0.0646 0.062
Schistosoma mansoni sulfide quinone reductase 0.003 0.0646 0.0646
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0924 0.0563
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0397 0.037
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0043 0.1074 0.0458
Loa Loa (eye worm) glutathione reductase 0.0323 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.004
Toxoplasma gondii alpha-tubulin I, putative 0.0184 0.5586 0.5281
Echinococcus granulosus beta tubulin 0.0099 0.2867 0.2847
Trypanosoma cruzi epsilon tubulin, putative 0.0099 0.2867 0.2375
Echinococcus multilocularis tubulin alpha chain 0.0184 0.5586 0.5574
Brugia malayi Tubulin beta chain 0.0056 0.1492 0.1467
Trypanosoma brucei epsilon tubulin 0.0099 0.2867 0.2375
Schistosoma mansoni alpha tubulin 0.0184 0.5586 0.5586
Loa Loa (eye worm) tubulin beta chain 0.0043 0.1074 0.1049
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0068 0.004
Leishmania major alpha tubulin 0.0184 0.5586 0.5281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0397 0.037
Echinococcus multilocularis Tubulin alpha 1 chain 0.0184 0.5586 0.5574
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0924 0.0297
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0397 0.0397
Echinococcus granulosus tubulin alpha 3 chain 0.0184 0.5586 0.5574
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0112 0.3268 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.003 0.0646 0.062
Trichomonas vaginalis tubulin alpha chain, putative 0.0099 0.2867 0.4496
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0214 0.6535 0.6525
Schistosoma mansoni glutamate synthase 0.003 0.0646 0.0646
Loa Loa (eye worm) STAT protein 0.0153 0.4589 0.4574
Plasmodium vivax glutathione reductase, putative 0.0323 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Entamoeba histolytica tubulin gamma chain 0.0099 0.2867 0.4496
Echinococcus multilocularis glutamate synthase 0.003 0.0646 0.062
Trypanosoma brucei alpha tubulin 0.0184 0.5586 0.5281
Echinococcus multilocularis Tubulin beta 2C chain 0.0099 0.2867 0.2847
Entamoeba histolytica tubulin family protein 0.0099 0.2867 0.4496
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0112 0.3268 1
Trypanosoma brucei zeta tubulin 0.0043 0.1074 0.0458
Loa Loa (eye worm) hypothetical protein 0.0022 0.0397 0.037
Giardia lamblia Epsilon tubulin 0.0043 0.1074 0.0867
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.3268 0.2803
Giardia lamblia Gamma tubulin 0.0099 0.2867 0.4496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0397 0.037
Toxoplasma gondii thioredoxin reductase 0.0323 1 1
Trypanosoma cruzi tubulin delta chain 0.0043 0.1074 0.0458
Echinococcus granulosus thioredoxin glutathione reductase 0.0323 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0397 0.037
Schistosoma mansoni tubulin subunit beta 0.0099 0.2867 0.2867
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0397 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.1074 0.0867
Giardia lamblia Alpha-tubulin 0.0184 0.5586 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0924 0.0297

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.63 uM Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation ChEMBL. 15481975
IC50 (functional) = 0.63 uM Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation ChEMBL. 15481975

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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