Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | purine nucleoside transporter | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 456 aa | 396 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.0222 | 0.0222 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.0222 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1096 | 0.2542 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.1096 | 0.2542 | 0.2542 |
Echinococcus granulosus | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0185 | 0.0222 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Echinococcus multilocularis | acetylcholinesterase | 0.1096 | 0.2542 | 0.2542 |
Echinococcus granulosus | carboxylesterase 5A | 0.1096 | 0.2542 | 0.2542 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0185 | 0.0222 | 0.0871 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.4024 | 1 | 1 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | hormone sensitive lipase | 0.4024 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Loa Loa (eye worm) | carboxylesterase | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0185 | 0.0222 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | neuroligin | 0.0185 | 0.0222 | 0.0222 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | carboxylesterase | 0.1096 | 0.2542 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Echinococcus granulosus | neuroligin | 0.0185 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1096 | 0.2542 | 0.2542 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0185 | 0.0222 | 0.0871 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0185 | 0.0222 | 0.0222 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0185 | 0.0222 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0185 | 0.0222 | 0.5 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0185 | 0.0222 | 0.0222 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1096 | 0.2542 | 0.2373 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0185 | 0.0222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.1096 | 0.2542 | 1 |
Onchocerca volvulus | 0.0185 | 0.0222 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 422 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Ki (binding) | = 422 nM | Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane | ChEMBL. | 15481982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.