Detailed information for compound 327885

Basic information

Technical information
  • TDR Targets ID: 327885
  • Name: 7-[(3S,4S)-3-amino-4-methylpyrrolidin-1-yl]-6 -fluoro-1-(4-hydroxyphenyl)-4-oxoquinoline-3- carboxylic acid
  • MW: 397.4 | Formula: C21H20FN3O4
  • H donors: 3 H acceptors: 4 LogP: 0.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)n1cc(C(=O)O)c(=O)c2c1cc(N1C[C@H]([C@H](C1)C)N)c(c2)F
  • InChi: 1S/C21H20FN3O4/c1-11-8-24(10-17(11)23)19-7-18-14(6-16(19)22)20(27)15(21(28)29)9-25(18)12-2-4-13(26)5-3-12/h2-7,9,11,17,26H,8,10,23H2,1H3,(H,28,29)/t11-,17+/m0/s1
  • InChiKey: UGZBXQQGAZNVHF-APPDUMDISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(3S,4S)-3-amino-4-methyl-pyrrolidin-1-yl]-6-fluoro-1-(4-hydroxyphenyl)-4-oxo-quinoline-3-carboxylic acid
  • 7-[(3S,4S)-3-amino-4-methyl-1-pyrrolidinyl]-6-fluoro-1-(4-hydroxyphenyl)-4-oxo-3-quinolinecarboxylic acid
  • 7-[(3S,4S)-3-azanyl-4-methyl-pyrrolidin-1-yl]-6-fluoro-1-(4-hydroxyphenyl)-4-oxo-quinoline-3-carboxylic acid
  • 7-[(3S,4S)-3-amino-4-methyl-pyrrolidino]-6-fluoro-1-(4-hydroxyphenyl)-4-keto-quinoline-3-carboxylic acid
  • 7-[(3S,4S)-3-amino-4-methyl-pyrrolidin-1-yl]-6-fluoro-1-(4-hydroxyphenyl)-4-keto-quinoline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi glutathione reductase 0.0037 0.0257 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0331 0.0747
Echinococcus granulosus neuropeptide receptor 0.0072 0.0585 0.1323
Echinococcus granulosus orexin receptor type 2 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0036 0.0243 0.3631
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi larval opioid receptor 0.0072 0.0585 0.0585
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0072 0.0585 0.0585
Echinococcus granulosus tachykinin peptides receptor 99D 0.0072 0.0585 0.1323
Schistosoma mansoni adenoreceptor 0.0072 0.0585 0.1323
Echinococcus multilocularis serotonin receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0707 0.3343
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Echinococcus granulosus g protein coupled receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis orexin receptor type 2 0.0072 0.0585 0.1323
Schistosoma mansoni amine GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0072 0.0585 0.1323
Schistosoma mansoni amine GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni neuropeptide receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0032 0.0204 0.0204
Echinococcus multilocularis G-protein coupled receptor, putative 0.0072 0.0585 0.1323
Onchocerca volvulus Neuropeptide F receptor homolog 0.0072 0.0585 0.8736
Onchocerca volvulus 0.0072 0.0585 0.8736
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0846 0.0846
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0243 0.106
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus geminin 0.0168 0.1492 0.3371
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0331 0.0331
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0331 0.0331
Brugia malayi neuropeptide F receptor 0.0072 0.0585 0.0585
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0072 0.0585 0.0585
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0331 0.0747
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0072 0.0585 0.0585
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0028
Echinococcus multilocularis serotonin receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0707 0.3343
Loa Loa (eye worm) TYRA-2 protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0548 0.5065 0.5065
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0257 0.3841
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0072 0.0585 0.1323
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0173 0.0173
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Echinococcus multilocularis sex peptide receptor 0.0072 0.0585 0.1323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Loa Loa (eye worm) carboxylesterase 0.048 0.4426 0.4426
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis GPCR, family 2 0.0032 0.0204 0.0461
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Treponema pallidum NADH oxidase 0.0013 0.0028 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0243 0.106
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Onchocerca volvulus 0.0072 0.0585 0.8736
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0331 0.0747
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0707 0.3343
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Carboxylesterase LipT 0.0081 0.067 0.3162
Echinococcus granulosus peptide allatostatin:somatostatin 0.0072 0.0585 0.1323
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0585 0.1323
Schistosoma mansoni amine GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0585 0.1323
Schistosoma mansoni neuropeptide receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0707 0.3343
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0243 0.106
Brugia malayi PHD-finger family protein 0.0029 0.0183 0.0183
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0028 0.0419
Brugia malayi PHD-finger family protein 0.0011 0.0012 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0243 0.106
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus 7tm_1 domain containing protein 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0243 0.0243
Schistosoma mansoni neuropeptide receptor 0.0072 0.0585 0.1323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0331 0.0747
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0585 0.0585
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0183 0.4462
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0585 0.1323
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0243 0.3631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Brugia malayi Dopamine receptor protein 1 0.0072 0.0585 0.0585
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0257 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0204 0.0461
Echinococcus multilocularis para nitrobenzyl esterase 0.0081 0.067 0.1514
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi G-protein coupled receptor 0.0072 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0029 0.0183 0.0415
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Echinococcus granulosus dro:myosuppressin receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0243 0.106
Echinococcus multilocularis acetylcholinesterase 0.048 0.4426 1
Echinococcus granulosus g-protein coupled receptor 0.0072 0.0585 0.1323
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0204 0.0461
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0796 0.3783
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0257 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2058 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni neuropeptide receptor 0.0072 0.0585 0.1323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni biogenic amine receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Mycobacterium leprae Probable lipase LipE 0.0036 0.0243 0.3056
Schistosoma mansoni growth hormone secretagogue receptor 0.0072 0.0585 0.1323
Brugia malayi AKH receptor 0.0072 0.0585 0.0585
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0063
Mycobacterium ulcerans lipase LipD 0.0036 0.0243 0.3631
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0013 0.0514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0028
Schistosoma mansoni BC026374 protein (S09 family) 0.0081 0.067 0.1514
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0072 0.0585 0.0585
Brugia malayi neuropeptide F receptor 0.0072 0.0585 0.0585
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0028 0.0682
Echinococcus multilocularis neuropeptide FF receptor 2 0.0072 0.0585 0.1323
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0221 0.2771
Echinococcus granulosus somatostatin receptor 0.0072 0.0585 0.1323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0204 0.0204
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0072 0.0585 0.0585
Toxoplasma gondii ABC1 family protein 0.0036 0.0243 0.5917
Echinococcus multilocularis peregrin 0.0029 0.0183 0.0415
Toxoplasma gondii thioredoxin reductase 0.0037 0.0257 0.6259
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0585 0.1323
Schistosoma mansoni hypothetical protein 0.0403 0.37 0.8362
Echinococcus granulosus neuropeptide FF receptor 2 0.0072 0.0585 0.1323
Brugia malayi CXXC zinc finger family protein 0.0028 0.0173 0.0173
Onchocerca volvulus 0.0072 0.0585 0.8736
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.37 0.8362
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0243 0.3631
Schistosoma mansoni cpg binding protein 0.003 0.0188 0.0425
Schistosoma mansoni inositol monophosphatase 0.0037 0.0257 0.0582
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0585 0.0585
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi putative neuropeptide receptor 0.0072 0.0585 0.0585
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0243 0.106
Echinococcus granulosus GPCR family 2 0.0032 0.0204 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0585 0.1323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0257 0.0581
Trichomonas vaginalis esterase, putative 0.0036 0.0243 0.3631
Echinococcus multilocularis dro:myosuppressin receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis geminin 0.0168 0.1492 0.3371
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0072 0.0585 0.1323
Schistosoma mansoni inositol monophosphatase 0.0037 0.0257 0.0582
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0072 0.0585 0.0585
Echinococcus multilocularis somatostatin receptor 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0072 0.0585 0.8736
Onchocerca volvulus 0.0072 0.0585 0.8736
Echinococcus multilocularis G protein coupled receptor 139 0.0072 0.0585 0.1323
Mycobacterium ulcerans beta-lactamase 0.0036 0.0243 0.3631
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0204 0.0204
Echinococcus granulosus alpha 1A adrenergic receptor 0.0072 0.0585 0.1323
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0257 0.0257
Schistosoma mansoni gliotactin 0.0081 0.067 0.1514
Onchocerca volvulus 0.0072 0.0585 0.8736
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0585 0.1323
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0585 0.1323
Echinococcus granulosus hypothetical protein 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.01 0.0846 0.0846
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0814 0.1839
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0081 0.067 1
Schistosoma mansoni myosin xvIII 0.0072 0.0585 0.1323
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0585 0.1323
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Brugia malayi Melatonin receptor type 1A 0.0072 0.0585 0.0585
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0106 0.0904 0.2649
Echinococcus granulosus g protein coupled receptor 0.0072 0.0585 0.1323
Entamoeba histolytica hypothetical protein 0.0106 0.0904 0.2649
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0257 0.0754
Schistosoma mansoni acetylcholinesterase 0.0081 0.067 0.1514
Schistosoma mansoni hypothetical protein 0.0032 0.0204 0.0461
Brugia malayi RE15519p 0.0072 0.0585 0.0585
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0028 0.109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0257 0.0582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.1072 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0796 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0072 0.0585 0.1323
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0814 0.1839
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0028 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0585 0.1323
Schistosoma mansoni hypothetical protein 0.0072 0.0585 0.1323
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0243 0.055
Brugia malayi Bromodomain containing protein 0.0029 0.0183 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0243 0.3631
Onchocerca volvulus 0.0072 0.0585 0.8736
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0028 0.0419
Echinococcus granulosus allatostatin A receptor 0.0072 0.0585 0.1323
Schistosoma mansoni opsin-like receptor 0.0072 0.0585 0.1323
Brugia malayi Thioredoxin reductase 0.0037 0.0257 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0183 0.7129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0221 0.0948
Schistosoma mansoni cpg binding protein 0.003 0.0188 0.0425
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0257 0.1129
Echinococcus multilocularis allatostatin A receptor 0.0072 0.0585 0.1323
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0072 0.0585 0.8736
Echinococcus multilocularis neuropeptide s receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0257 0.0257
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0028 1
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0013 0.0514
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0028 0.0028
Echinococcus granulosus cpg binding protein 0.003 0.0188 0.0425
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0183 0.4462
Brugia malayi Carboxylesterase family protein 0.0081 0.067 0.067
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0011 0.0025
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0257 0.023
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0183 0.0415
Echinococcus granulosus dnaJ subfamily B 0.0403 0.37 0.8362
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0585 0.1323
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0028 0.0173 0.258
Loa Loa (eye worm) inositol-1 0.0037 0.0257 0.0257
Mycobacterium tuberculosis Conserved protein 0.0036 0.0243 0.106
Mycobacterium ulcerans carboxylesterase, LipT 0.0081 0.067 1
Echinococcus granulosus acetylcholinesterase 0.048 0.4426 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0028 0.109
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0028 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0411 1
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0585 0.1323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0331 0.0747
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Schistosoma mansoni opsin-like receptor 0.0072 0.0585 0.1323
Plasmodium falciparum thioredoxin reductase 0.0013 0.0028 0.109
Echinococcus granulosus G protein coupled receptor 139 0.0072 0.0585 0.1323
Loa Loa (eye worm) melatonin receptor type 1A 0.0072 0.0585 0.0585
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0032 0.0204 0.0461
Brugia malayi jmjC domain containing protein 0.0037 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.0072 0.0585 0.1323
Loa Loa (eye worm) carboxylesterase 0.0081 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.067 0.1514
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0028 0.0082
Echinococcus granulosus neuroligin 0.0081 0.067 0.1514
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0072 0.0585 0.1323
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0063
Schistosoma mansoni hypothetical protein 0.0032 0.0204 0.0461
Loa Loa (eye worm) hypothetical protein 0.005 0.0381 0.0381
Brugia malayi putative neuropeptide receptor NPR1 0.0072 0.0585 0.0585
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0072 0.0585 0.0585
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0257 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Brugia malayi Tachykinin-like peptides receptor 99D 0.0072 0.0585 0.0585
Brugia malayi jmjC domain containing protein 0.0096 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.0068 0.0549 0.0549
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0028 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0331 0.0747
Onchocerca volvulus 0.0072 0.0585 0.8736
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0796 0.3783
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0585 0.1323
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0183
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0028 0.109
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0585 0.1323
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0072 0.0585 0.1323
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0331 0.0747
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0585 0.0585
Brugia malayi GnHR receptor homolog 0.0072 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0068 0.0549 0.1241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Brugia malayi beta-lactamase 0.0036 0.0243 0.0243
Echinococcus multilocularis BC026374 protein (S09 family) 0.0081 0.067 0.1514
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0796 0.3783
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0257 0.0581
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) acetylcholinesterase 1 0.048 0.4426 0.4426
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0243 0.106
Echinococcus granulosus serotonin receptor 0.0072 0.0585 0.1323
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0028 0.109
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0072 0.0585 0.1323
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis carboxylesterase 5A 0.048 0.4426 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.048 0.4426 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0243 0.055
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0243 0.3056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0072 0.0585 0.0585
Onchocerca volvulus 0.0036 0.0243 0.3631
Onchocerca volvulus 0.0072 0.0585 0.8736
Brugia malayi follicle stimulating hormone receptor 0.0072 0.0585 0.0585
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0292 0.066
Schistosoma mansoni neuroligin 3 (S09 family) 0.0081 0.067 0.1514
Plasmodium falciparum glutathione reductase 0.0037 0.0257 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0243 0.9454
Echinococcus granulosus acetylcholinesterase 0.048 0.4426 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0243 0.0243
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0081 0.067 0.1514
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0028 0.0419
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0072 0.0585 0.1323
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0028 0.0028
Onchocerca volvulus 0.0072 0.0585 0.8736
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Onchocerca volvulus 0.0081 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Brugia malayi Serotonin receptor 0.0072 0.0585 0.0585
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0081 0.067 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0257 0.626
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0707 0.8878
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0262 0.0592
Loa Loa (eye worm) hypothetical protein 0.048 0.4426 0.4426
Onchocerca volvulus 0.0081 0.067 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0478 0.0478
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0257 0.3841
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0028 0.0028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0204 0.0461
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0262 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0243 0.0243
Onchocerca volvulus 0.0036 0.0243 0.3631
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1072 1 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0183 0.2738
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0028 0.0028
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0585 0.1323
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0373 0.3414 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) carboxylesterase 0.0081 0.067 0.067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0243 0.055
Brugia malayi Serotonin receptor 0.0072 0.0585 0.0585
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0028 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0257 0.0257
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0472 0.1065
Loa Loa (eye worm) glutathione reductase 0.0037 0.0257 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0585 0.1323
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.3631
Brugia malayi Dopamine receptor 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi beta-lactamase family protein 0.0036 0.0243 0.0243
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0585 0.1323
Brugia malayi Carboxylesterase family protein 0.0081 0.067 0.067
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0257 0.3841
Leishmania major trypanothione reductase 0.0037 0.0257 0.023
Schistosoma mansoni biogenic amine receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0072 0.0585 0.1323
Schistosoma mansoni hypothetical protein 0.0168 0.1492 0.3371
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0257 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Giardia lamblia PHD finger protein 15 0.0029 0.0183 0.0537
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0183 0.0415
Onchocerca volvulus 0.0072 0.0585 0.8736
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Onchocerca volvulus 0.0072 0.0585 0.8736
Schistosoma mansoni hypothetical protein 0.0032 0.0204 0.0461
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0846 0.0846
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0072 0.0585 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0072 0.0585 0.1323
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0072 0.0585 0.1323
Brugia malayi ORL1-like opioid receptor 0.0072 0.0585 0.0585
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Conserved protein 0.0036 0.0243 0.106
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Leishmania major C-8 sterol isomerase-like protein 0.1072 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0585 0.1323
Echinococcus granulosus sex peptide receptor 0.0072 0.0585 0.1323
Echinococcus granulosus 7TM GPCR rhodopsin 0.0072 0.0585 0.1323
Brugia malayi G protein-coupled receptor 0.0072 0.0585 0.0585
Leishmania major hypothetical protein, conserved 0.0036 0.0243 0.0216
Echinococcus multilocularis cpg binding protein 0.003 0.0188 0.0425
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0846 0.0846
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Brugia malayi G-protein coupled receptor 0.0072 0.0585 0.0585
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0585 0.1323
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Echinococcus granulosus peregrin 0.0029 0.0183 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Giardia lamblia DNA repair protein RAD52 0.0373 0.3414 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0078 0.0078
Brugia malayi Carboxylesterase family protein 0.048 0.4426 0.4426
Mycobacterium ulcerans hypothetical protein 0.0036 0.0243 0.3631
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0081 0.067 0.3162
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0585 0.1323
Onchocerca volvulus 0.0072 0.0585 0.8736
Brugia malayi Carboxylesterase family protein 0.048 0.4426 0.4426
Brugia malayi hypothetical protein 0.0081 0.067 0.067
Onchocerca volvulus 0.0072 0.0585 0.8736
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0081 0.067 0.3162
Echinococcus multilocularis acetylcholinesterase 0.048 0.4426 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0257 0.3841
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0028 0.0419
Onchocerca volvulus 0.0072 0.0585 0.8736
Brugia malayi hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0072 0.0585 0.1323
Plasmodium vivax glutathione reductase, putative 0.0037 0.0257 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0072 0.0585 0.8736
Trypanosoma brucei C-8 sterol isomerase, putative 0.1072 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0585 0.1323
Schistosoma mansoni cpg binding protein 0.0028 0.0173 0.0391
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0183 0.0183
Plasmodium falciparum phd finger protein, putative 0.0029 0.0183 0.7129
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.3631
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0081 0.067 0.1514
Brugia malayi Carboxylesterase family protein 0.0081 0.067 0.067
Brugia malayi Carboxylesterase family protein 0.0081 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0072 0.0585 0.1323
Echinococcus granulosus neuropeptide receptor A26 0.0072 0.0585 0.1323
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0585 0.1323
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0292 0.066
Schistosoma mansoni opsin-like receptor 0.0072 0.0585 0.1323
Echinococcus granulosus neuropeptide s receptor 0.0072 0.0585 0.1323
Brugia malayi beta-lactamase family protein 0.0036 0.0243 0.0243
Schistosoma mansoni amine GPCR 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0243
Plasmodium falciparum glutathione reductase 0.0013 0.0028 0.109
Onchocerca volvulus 0.0081 0.067 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0072 0.0585 0.1323
Trichomonas vaginalis spcc417.12 protein, putative 0.0081 0.067 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0257 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.0707 0.3343
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0242 0.0546
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.3631
Brugia malayi Dopamine receptor protein 2 0.0072 0.0585 0.0585
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0627 0.1417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0585 0.1323
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0243 0.055
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0028 0.0682
Brugia malayi sulfakinin receptor protein 0.0072 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0063 0.0143
Echinococcus multilocularis neuroligin 0.0081 0.067 0.1514
Echinococcus multilocularis g-protein coupled receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Onchocerca volvulus 0.0081 0.067 1
Brugia malayi Inositol-1 0.0037 0.0257 0.0257
Brugia malayi G protein-coupled receptor F59B2.13 0.0072 0.0585 0.0585
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0028 0.109
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.067 0.1514
Schistosoma mansoni histamine h1 receptor 0.0072 0.0585 0.1323
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0183 0.0415
Trypanosoma brucei trypanothione reductase 0.0037 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus carboxylesterase 5A 0.048 0.4426 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0204 0.0461
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni biogenic amine receptor 0.0072 0.0585 0.1323
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0243 0.3631
Loa Loa (eye worm) beta-lactamase 0.0036 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.048 0.4426 0.4426
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0243 0.106
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0072 0.0585 0.1323
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0585 0.1323
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0072 0.0585 0.1323
Echinococcus granulosus para nitrobenzyl esterase 0.0081 0.067 0.1514
Echinococcus granulosus g protein coupled receptor 0.0072 0.0585 0.1323
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.067 0.1514
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0072 0.0585 0.1323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0257 1
Echinococcus granulosus BC026374 protein S09 family 0.0081 0.067 0.1514
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0028 0.0028
Onchocerca volvulus 0.0072 0.0585 0.8736
Echinococcus granulosus fmrfamide receptor 0.0072 0.0585 0.1323
Schistosoma mansoni hypothetical protein 0.0168 0.1492 0.3371
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0072 0.0585 0.0585
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0072 0.0585 0.0585
Echinococcus granulosus neuropeptide receptor 0.0072 0.0585 0.1323
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0707 0.3343
Schistosoma mansoni neuropeptide f receptor 76f 0.0072 0.0585 0.1323

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Staphylococcus aureus strain St au 29213 ChEMBL. 15341485
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Staphylococcus aureus strain St au 33591 MRSA ChEMBL. 15341485
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Escherichia coli strain 25922 ChEMBL. 15341485
MIC (functional) = 0.2 ug ml-1 Antibacterial activity against Escherichia coli strain 25922 ChEMBL. 15341485
MIC (functional) = 1.56 ug ml-1 Antibacterial activity against Enterococcus faecalis strain 29212 ChEMBL. 15341485
MIC (functional) = 1.56 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa strain 27853 ChEMBL. 15341485

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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